| Full name: kallikrein B1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4q35.2 | ||
| Entrez ID: 3818 | HGNC ID: HGNC:6371 | Ensembl Gene: ENSG00000164344 | OMIM ID: 229000 |
| Drug and gene relationship at DGIdb | |||
KLKB1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04610 | Complement and coagulation cascades |
Expression of KLKB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLKB1 | 3818 | 206541_at | -0.3903 | 0.0835 | |
| GSE20347 | KLKB1 | 3818 | 206541_at | -0.0261 | 0.7891 | |
| GSE23400 | KLKB1 | 3818 | 206541_at | -0.1592 | 0.0000 | |
| GSE26886 | KLKB1 | 3818 | 206541_at | -0.0239 | 0.8576 | |
| GSE29001 | KLKB1 | 3818 | 206541_at | -0.1058 | 0.5381 | |
| GSE38129 | KLKB1 | 3818 | 206541_at | -0.2271 | 0.0127 | |
| GSE45670 | KLKB1 | 3818 | 206541_at | -0.3234 | 0.0047 | |
| GSE53622 | KLKB1 | 3818 | 39347 | -2.8654 | 0.0000 | |
| GSE53624 | KLKB1 | 3818 | 39347 | -2.8973 | 0.0000 | |
| GSE63941 | KLKB1 | 3818 | 206541_at | 0.1054 | 0.5376 | |
| GSE77861 | KLKB1 | 3818 | 206541_at | -0.1120 | 0.3409 | |
| GSE97050 | KLKB1 | 3818 | A_23_P252236 | -1.8006 | 0.0607 | |
| TCGA | KLKB1 | 3818 | RNAseq | -1.7830 | 0.0131 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by KLKB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLKB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLKB1 | 3818 | 2 | 11 | 17 | |
| GSE20123 | KLKB1 | 3818 | 2 | 11 | 17 | |
| GSE43470 | KLKB1 | 3818 | 1 | 14 | 28 | |
| GSE46452 | KLKB1 | 3818 | 1 | 36 | 22 | |
| GSE47630 | KLKB1 | 3818 | 0 | 22 | 18 | |
| GSE54993 | KLKB1 | 3818 | 10 | 0 | 60 | |
| GSE54994 | KLKB1 | 3818 | 3 | 12 | 38 | |
| GSE60625 | KLKB1 | 3818 | 0 | 0 | 11 | |
| GSE74703 | KLKB1 | 3818 | 1 | 11 | 24 | |
| GSE74704 | KLKB1 | 3818 | 1 | 5 | 14 | |
| TCGA | KLKB1 | 3818 | 10 | 34 | 52 |
Total number of gains: 31; Total number of losses: 156; Total Number of normals: 301.
Somatic mutations of KLKB1:
Generating mutation plots.
Highly correlated genes for KLKB1:
Showing top 20/690 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLKB1 | ARID5A | 0.891949 | 3 | 0 | 3 |
| KLKB1 | KRTAP20-1 | 0.891114 | 3 | 0 | 3 |
| KLKB1 | OR10G8 | 0.883257 | 3 | 0 | 3 |
| KLKB1 | OR2Z1 | 0.861764 | 3 | 0 | 3 |
| KLKB1 | FAM163B | 0.857838 | 3 | 0 | 3 |
| KLKB1 | NCCRP1 | 0.823605 | 3 | 0 | 3 |
| KLKB1 | MFSD2B | 0.805871 | 3 | 0 | 3 |
| KLKB1 | MUC22 | 0.80443 | 3 | 0 | 3 |
| KLKB1 | SLC6A4 | 0.785154 | 4 | 0 | 4 |
| KLKB1 | KPRP | 0.779496 | 3 | 0 | 3 |
| KLKB1 | OTOP3 | 0.775468 | 3 | 0 | 3 |
| KLKB1 | MYZAP | 0.773104 | 3 | 0 | 3 |
| KLKB1 | GPX6 | 0.768758 | 3 | 0 | 3 |
| KLKB1 | DKK4 | 0.767872 | 6 | 0 | 6 |
| KLKB1 | BARHL2 | 0.762069 | 3 | 0 | 3 |
| KLKB1 | LYNX1 | 0.76179 | 4 | 0 | 4 |
| KLKB1 | TECPR1 | 0.760656 | 3 | 0 | 3 |
| KLKB1 | TMPRSS11A | 0.760058 | 3 | 0 | 3 |
| KLKB1 | MORN3 | 0.757265 | 4 | 0 | 3 |
| KLKB1 | TEN1 | 0.755949 | 3 | 0 | 3 |
For details and further investigation, click here
