| Full name: solute carrier family 6 member 4 | Alias Symbol: 5-HTT|SERT1 | ||
| Type: protein-coding gene | Cytoband: 17q11.2 | ||
| Entrez ID: 6532 | HGNC ID: HGNC:11050 | Ensembl Gene: ENSG00000108576 | OMIM ID: 182138 |
| Drug and gene relationship at DGIdb | |||
Expression of SLC6A4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC6A4 | 6532 | 207519_at | -0.7799 | 0.0318 | |
| GSE20347 | SLC6A4 | 6532 | 207519_at | -0.5616 | 0.0028 | |
| GSE23400 | SLC6A4 | 6532 | 207519_at | -0.2350 | 0.0000 | |
| GSE26886 | SLC6A4 | 6532 | 207519_at | -1.0151 | 0.0001 | |
| GSE29001 | SLC6A4 | 6532 | 207519_at | -0.6260 | 0.0058 | |
| GSE38129 | SLC6A4 | 6532 | 207519_at | -0.6023 | 0.0014 | |
| GSE45670 | SLC6A4 | 6532 | 207519_at | -0.4952 | 0.0458 | |
| GSE53622 | SLC6A4 | 6532 | 42101 | -1.5273 | 0.0000 | |
| GSE53624 | SLC6A4 | 6532 | 42101 | -1.4136 | 0.0000 | |
| GSE63941 | SLC6A4 | 6532 | 207519_at | 0.1082 | 0.3911 | |
| GSE77861 | SLC6A4 | 6532 | 207519_at | -0.4162 | 0.3017 | |
| GSE97050 | SLC6A4 | 6532 | A_23_P152995 | -0.9288 | 0.2335 | |
| SRP007169 | SLC6A4 | 6532 | RNAseq | -0.8468 | 0.2786 | |
| SRP064894 | SLC6A4 | 6532 | RNAseq | -3.3097 | 0.0000 | |
| SRP133303 | SLC6A4 | 6532 | RNAseq | -2.1302 | 0.0000 | |
| SRP159526 | SLC6A4 | 6532 | RNAseq | -1.7460 | 0.0012 | |
| SRP193095 | SLC6A4 | 6532 | RNAseq | -2.3829 | 0.0000 | |
| TCGA | SLC6A4 | 6532 | RNAseq | 0.0693 | 0.9162 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by SLC6A4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC6A4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC6A4 | 6532 | 7 | 2 | 21 | |
| GSE20123 | SLC6A4 | 6532 | 8 | 2 | 20 | |
| GSE43470 | SLC6A4 | 6532 | 0 | 1 | 42 | |
| GSE46452 | SLC6A4 | 6532 | 33 | 1 | 25 | |
| GSE47630 | SLC6A4 | 6532 | 7 | 1 | 32 | |
| GSE54993 | SLC6A4 | 6532 | 2 | 3 | 65 | |
| GSE54994 | SLC6A4 | 6532 | 7 | 5 | 41 | |
| GSE60625 | SLC6A4 | 6532 | 4 | 0 | 7 | |
| GSE74703 | SLC6A4 | 6532 | 0 | 1 | 35 | |
| GSE74704 | SLC6A4 | 6532 | 5 | 2 | 13 | |
| TCGA | SLC6A4 | 6532 | 20 | 10 | 66 |
Total number of gains: 93; Total number of losses: 28; Total Number of normals: 367.
Somatic mutations of SLC6A4:
Generating mutation plots.
Highly correlated genes for SLC6A4:
Showing top 20/970 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC6A4 | KLKB1 | 0.785154 | 4 | 0 | 4 |
| SLC6A4 | IQCF1 | 0.783238 | 3 | 0 | 3 |
| SLC6A4 | FAM163B | 0.782007 | 3 | 0 | 3 |
| SLC6A4 | KPRP | 0.765282 | 3 | 0 | 3 |
| SLC6A4 | MUC22 | 0.763377 | 3 | 0 | 3 |
| SLC6A4 | NCCRP1 | 0.749729 | 3 | 0 | 3 |
| SLC6A4 | MYZAP | 0.748666 | 3 | 0 | 3 |
| SLC6A4 | MFSD2B | 0.746473 | 3 | 0 | 3 |
| SLC6A4 | KRTAP20-1 | 0.741278 | 3 | 0 | 3 |
| SLC6A4 | SMIM5 | 0.738542 | 5 | 0 | 5 |
| SLC6A4 | OTOP3 | 0.734331 | 3 | 0 | 3 |
| SLC6A4 | ANKRD24 | 0.733725 | 3 | 0 | 3 |
| SLC6A4 | OR2Z1 | 0.728965 | 3 | 0 | 3 |
| SLC6A4 | ACER1 | 0.721747 | 6 | 0 | 5 |
| SLC6A4 | ANKRD18B | 0.717893 | 4 | 0 | 4 |
| SLC6A4 | GPX6 | 0.716792 | 3 | 0 | 3 |
| SLC6A4 | TMPRSS11A | 0.708343 | 3 | 0 | 3 |
| SLC6A4 | RNF222 | 0.707381 | 3 | 0 | 3 |
| SLC6A4 | ATG9B | 0.706417 | 5 | 0 | 4 |
| SLC6A4 | HES5 | 0.703961 | 4 | 0 | 4 |
For details and further investigation, click here
