| Full name: dedicator of cytokinesis 10 | Alias Symbol: ZIZ3|KIAA0694 | ||
| Type: protein-coding gene | Cytoband: 2q36.2 | ||
| Entrez ID: 55619 | HGNC ID: HGNC:23479 | Ensembl Gene: ENSG00000135905 | OMIM ID: 611518 |
| Drug and gene relationship at DGIdb | |||
Expression of DOCK10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DOCK10 | 55619 | 219279_at | -0.5012 | 0.6053 | |
| GSE20347 | DOCK10 | 55619 | 219279_at | -0.4924 | 0.0022 | |
| GSE23400 | DOCK10 | 55619 | 219279_at | -0.0101 | 0.8774 | |
| GSE26886 | DOCK10 | 55619 | 219279_at | -0.7451 | 0.0221 | |
| GSE29001 | DOCK10 | 55619 | 219279_at | -0.2089 | 0.6790 | |
| GSE38129 | DOCK10 | 55619 | 219279_at | -0.4102 | 0.0409 | |
| GSE45670 | DOCK10 | 55619 | 219279_at | -0.7618 | 0.0104 | |
| GSE63941 | DOCK10 | 55619 | 219279_at | -2.4925 | 0.0088 | |
| GSE77861 | DOCK10 | 55619 | 215151_at | -0.1337 | 0.1323 | |
| GSE97050 | DOCK10 | 55619 | A_23_P16722 | 0.4817 | 0.2270 | |
| SRP007169 | DOCK10 | 55619 | RNAseq | 0.7358 | 0.2517 | |
| SRP008496 | DOCK10 | 55619 | RNAseq | 0.4575 | 0.1728 | |
| SRP064894 | DOCK10 | 55619 | RNAseq | 0.1453 | 0.6754 | |
| SRP133303 | DOCK10 | 55619 | RNAseq | -0.3788 | 0.0235 | |
| SRP159526 | DOCK10 | 55619 | RNAseq | -1.0817 | 0.0672 | |
| SRP193095 | DOCK10 | 55619 | RNAseq | -0.3517 | 0.0382 | |
| SRP219564 | DOCK10 | 55619 | RNAseq | -0.0779 | 0.8843 | |
| TCGA | DOCK10 | 55619 | RNAseq | 0.1203 | 0.3519 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by DOCK10 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of DOCK10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DOCK10 | 55619 | 2 | 12 | 16 | |
| GSE20123 | DOCK10 | 55619 | 2 | 12 | 16 | |
| GSE43470 | DOCK10 | 55619 | 0 | 7 | 36 | |
| GSE46452 | DOCK10 | 55619 | 0 | 5 | 54 | |
| GSE47630 | DOCK10 | 55619 | 4 | 5 | 31 | |
| GSE54993 | DOCK10 | 55619 | 1 | 2 | 67 | |
| GSE54994 | DOCK10 | 55619 | 6 | 10 | 37 | |
| GSE60625 | DOCK10 | 55619 | 3 | 0 | 8 | |
| GSE74703 | DOCK10 | 55619 | 0 | 6 | 30 | |
| GSE74704 | DOCK10 | 55619 | 2 | 6 | 12 | |
| TCGA | DOCK10 | 55619 | 13 | 27 | 56 |
Total number of gains: 33; Total number of losses: 92; Total Number of normals: 363.
Somatic mutations of DOCK10:
Generating mutation plots.
Highly correlated genes for DOCK10:
Showing top 20/610 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DOCK10 | GIMAP7 | 0.805688 | 5 | 0 | 5 |
| DOCK10 | SETD7 | 0.801598 | 3 | 0 | 3 |
| DOCK10 | ANKRD44 | 0.795838 | 5 | 0 | 5 |
| DOCK10 | DOK1 | 0.764954 | 3 | 0 | 3 |
| DOCK10 | CD48 | 0.764271 | 7 | 0 | 7 |
| DOCK10 | PCGF5 | 0.757523 | 3 | 0 | 3 |
| DOCK10 | MPEG1 | 0.753835 | 4 | 0 | 4 |
| DOCK10 | FGF7 | 0.745611 | 3 | 0 | 3 |
| DOCK10 | SNX20 | 0.741558 | 4 | 0 | 4 |
| DOCK10 | BTLA | 0.732249 | 3 | 0 | 3 |
| DOCK10 | GIMAP8 | 0.731301 | 5 | 0 | 4 |
| DOCK10 | ELAC1 | 0.726557 | 3 | 0 | 3 |
| DOCK10 | NCKAP1L | 0.721734 | 6 | 0 | 6 |
| DOCK10 | ACBD3 | 0.720247 | 3 | 0 | 3 |
| DOCK10 | PARVG | 0.719493 | 4 | 0 | 4 |
| DOCK10 | APOL6 | 0.711569 | 3 | 0 | 3 |
| DOCK10 | INPP5D | 0.711524 | 9 | 0 | 8 |
| DOCK10 | CD53 | 0.701578 | 8 | 0 | 7 |
| DOCK10 | KLRB1 | 0.701108 | 8 | 0 | 7 |
| DOCK10 | ARHGEF6 | 0.698992 | 10 | 0 | 9 |
For details and further investigation, click here
