| Full name: L3MBTL histone methyl-lysine binding protein 3 | Alias Symbol: KIAA1798 | ||
| Type: protein-coding gene | Cytoband: 6q23.1 | ||
| Entrez ID: 84456 | HGNC ID: HGNC:23035 | Ensembl Gene: ENSG00000198945 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of L3MBTL3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | L3MBTL3 | 84456 | 229393_at | 0.4791 | 0.3797 | |
| GSE26886 | L3MBTL3 | 84456 | 229393_at | 0.0512 | 0.8788 | |
| GSE45670 | L3MBTL3 | 84456 | 229393_at | -0.4036 | 0.0524 | |
| GSE53622 | L3MBTL3 | 84456 | 125152 | 0.2442 | 0.0614 | |
| GSE53624 | L3MBTL3 | 84456 | 125152 | 0.3335 | 0.0351 | |
| GSE63941 | L3MBTL3 | 84456 | 229393_at | -1.2512 | 0.0877 | |
| GSE77861 | L3MBTL3 | 84456 | 229393_at | 0.2630 | 0.1407 | |
| GSE97050 | L3MBTL3 | 84456 | A_23_P311885 | 0.1399 | 0.4762 | |
| SRP007169 | L3MBTL3 | 84456 | RNAseq | 1.5821 | 0.0072 | |
| SRP008496 | L3MBTL3 | 84456 | RNAseq | 1.9401 | 0.0000 | |
| SRP064894 | L3MBTL3 | 84456 | RNAseq | 0.7027 | 0.0030 | |
| SRP133303 | L3MBTL3 | 84456 | RNAseq | 0.5124 | 0.0021 | |
| SRP159526 | L3MBTL3 | 84456 | RNAseq | 0.7074 | 0.0257 | |
| SRP193095 | L3MBTL3 | 84456 | RNAseq | 0.6470 | 0.0001 | |
| SRP219564 | L3MBTL3 | 84456 | RNAseq | 0.1579 | 0.6819 | |
| TCGA | L3MBTL3 | 84456 | RNAseq | 0.1657 | 0.0361 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by L3MBTL3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of L3MBTL3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | L3MBTL3 | 84456 | 1 | 4 | 25 | |
| GSE20123 | L3MBTL3 | 84456 | 1 | 3 | 26 | |
| GSE43470 | L3MBTL3 | 84456 | 5 | 0 | 38 | |
| GSE46452 | L3MBTL3 | 84456 | 2 | 11 | 46 | |
| GSE47630 | L3MBTL3 | 84456 | 9 | 4 | 27 | |
| GSE54993 | L3MBTL3 | 84456 | 3 | 3 | 64 | |
| GSE54994 | L3MBTL3 | 84456 | 9 | 7 | 37 | |
| GSE60625 | L3MBTL3 | 84456 | 0 | 1 | 10 | |
| GSE74703 | L3MBTL3 | 84456 | 4 | 0 | 32 | |
| GSE74704 | L3MBTL3 | 84456 | 0 | 1 | 19 | |
| TCGA | L3MBTL3 | 84456 | 11 | 18 | 67 |
Total number of gains: 45; Total number of losses: 52; Total Number of normals: 391.
Somatic mutations of L3MBTL3:
Generating mutation plots.
Highly correlated genes for L3MBTL3:
Showing top 20/651 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| L3MBTL3 | PLOD3 | 0.783759 | 3 | 0 | 3 |
| L3MBTL3 | ZNF184 | 0.780173 | 3 | 0 | 3 |
| L3MBTL3 | RNF138 | 0.776052 | 3 | 0 | 3 |
| L3MBTL3 | NOL9 | 0.775068 | 3 | 0 | 3 |
| L3MBTL3 | RHBDD2 | 0.765655 | 3 | 0 | 3 |
| L3MBTL3 | TBL2 | 0.765414 | 3 | 0 | 3 |
| L3MBTL3 | SIDT2 | 0.764369 | 3 | 0 | 3 |
| L3MBTL3 | SDHAF2 | 0.761853 | 3 | 0 | 3 |
| L3MBTL3 | PFAS | 0.754797 | 3 | 0 | 3 |
| L3MBTL3 | CLP1 | 0.754748 | 3 | 0 | 3 |
| L3MBTL3 | SLC25A14 | 0.750155 | 4 | 0 | 4 |
| L3MBTL3 | COMMD7 | 0.745012 | 3 | 0 | 3 |
| L3MBTL3 | SBNO1 | 0.743343 | 3 | 0 | 3 |
| L3MBTL3 | DDB1 | 0.737103 | 3 | 0 | 3 |
| L3MBTL3 | MRFAP1 | 0.734847 | 3 | 0 | 3 |
| L3MBTL3 | SLC7A6 | 0.733875 | 3 | 0 | 3 |
| L3MBTL3 | CHCHD6 | 0.732667 | 3 | 0 | 3 |
| L3MBTL3 | SYTL2 | 0.729128 | 5 | 0 | 4 |
| L3MBTL3 | SGTB | 0.726308 | 4 | 0 | 4 |
| L3MBTL3 | USP24 | 0.721631 | 3 | 0 | 3 |
For details and further investigation, click here
