| Full name: laminin subunit alpha 4 | Alias Symbol: LAMA3 | ||
| Type: protein-coding gene | Cytoband: 6q21 | ||
| Entrez ID: 3910 | HGNC ID: HGNC:6484 | Ensembl Gene: ENSG00000112769 | OMIM ID: 600133 |
| Drug and gene relationship at DGIdb | |||
LAMA4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion | |
| hsa05200 | Pathways in cancer | |
| hsa05222 | Small cell lung cancer |
Expression of LAMA4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LAMA4 | 3910 | 202202_s_at | -0.3505 | 0.7481 | |
| GSE20347 | LAMA4 | 3910 | 202202_s_at | 0.7548 | 0.0294 | |
| GSE23400 | LAMA4 | 3910 | 202202_s_at | 0.2219 | 0.3079 | |
| GSE26886 | LAMA4 | 3910 | 202202_s_at | 2.7209 | 0.0000 | |
| GSE29001 | LAMA4 | 3910 | 202202_s_at | 0.5036 | 0.2474 | |
| GSE38129 | LAMA4 | 3910 | 202202_s_at | 0.2214 | 0.6405 | |
| GSE45670 | LAMA4 | 3910 | 202202_s_at | -1.3377 | 0.0140 | |
| GSE53622 | LAMA4 | 3910 | 14389 | 0.0846 | 0.6149 | |
| GSE53624 | LAMA4 | 3910 | 14389 | 0.3841 | 0.0008 | |
| GSE63941 | LAMA4 | 3910 | 210990_s_at | -2.2691 | 0.0002 | |
| GSE77861 | LAMA4 | 3910 | 210089_s_at | -0.0694 | 0.6128 | |
| GSE97050 | LAMA4 | 3910 | A_33_P3308749 | -0.2576 | 0.4049 | |
| SRP007169 | LAMA4 | 3910 | RNAseq | 3.5175 | 0.0000 | |
| SRP008496 | LAMA4 | 3910 | RNAseq | 3.9964 | 0.0000 | |
| SRP064894 | LAMA4 | 3910 | RNAseq | 0.8085 | 0.0083 | |
| SRP133303 | LAMA4 | 3910 | RNAseq | 0.3895 | 0.2299 | |
| SRP159526 | LAMA4 | 3910 | RNAseq | 0.4425 | 0.2554 | |
| SRP193095 | LAMA4 | 3910 | RNAseq | 1.7178 | 0.0000 | |
| SRP219564 | LAMA4 | 3910 | RNAseq | -0.2519 | 0.7537 | |
| TCGA | LAMA4 | 3910 | RNAseq | -0.1717 | 0.0782 |
Upregulated datasets: 4; Downregulated datasets: 2.
Survival by LAMA4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LAMA4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LAMA4 | 3910 | 1 | 4 | 25 | |
| GSE20123 | LAMA4 | 3910 | 1 | 3 | 26 | |
| GSE43470 | LAMA4 | 3910 | 3 | 1 | 39 | |
| GSE46452 | LAMA4 | 3910 | 2 | 11 | 46 | |
| GSE47630 | LAMA4 | 3910 | 9 | 4 | 27 | |
| GSE54993 | LAMA4 | 3910 | 3 | 2 | 65 | |
| GSE54994 | LAMA4 | 3910 | 8 | 8 | 37 | |
| GSE60625 | LAMA4 | 3910 | 0 | 2 | 9 | |
| GSE74703 | LAMA4 | 3910 | 2 | 1 | 33 | |
| GSE74704 | LAMA4 | 3910 | 0 | 1 | 19 | |
| TCGA | LAMA4 | 3910 | 6 | 23 | 67 |
Total number of gains: 35; Total number of losses: 60; Total Number of normals: 393.
Somatic mutations of LAMA4:
Generating mutation plots.
Highly correlated genes for LAMA4:
Showing top 20/996 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LAMA4 | DNM3OS | 0.845492 | 3 | 0 | 3 |
| LAMA4 | FSTL1 | 0.838229 | 12 | 0 | 12 |
| LAMA4 | FBN1 | 0.837056 | 10 | 0 | 10 |
| LAMA4 | FERMT2 | 0.826579 | 12 | 0 | 12 |
| LAMA4 | CALD1 | 0.81873 | 12 | 0 | 12 |
| LAMA4 | FILIP1L | 0.804908 | 12 | 0 | 12 |
| LAMA4 | C20orf194 | 0.798828 | 3 | 0 | 3 |
| LAMA4 | ZEB1 | 0.797742 | 3 | 0 | 3 |
| LAMA4 | ANTXR2 | 0.797217 | 8 | 0 | 8 |
| LAMA4 | CLMP | 0.791972 | 7 | 0 | 6 |
| LAMA4 | COL6A1 | 0.783992 | 12 | 0 | 12 |
| LAMA4 | ZNF579 | 0.780876 | 3 | 0 | 3 |
| LAMA4 | C11orf96 | 0.779514 | 5 | 0 | 5 |
| LAMA4 | COL15A1 | 0.774884 | 12 | 0 | 12 |
| LAMA4 | IGFBP7 | 0.774431 | 12 | 0 | 11 |
| LAMA4 | EFEMP2 | 0.7704 | 12 | 0 | 12 |
| LAMA4 | ITGA1 | 0.770175 | 12 | 0 | 12 |
| LAMA4 | MICAL2 | 0.767405 | 10 | 0 | 9 |
| LAMA4 | LAMC1 | 0.766818 | 12 | 0 | 12 |
| LAMA4 | DCHS1 | 0.762216 | 10 | 0 | 9 |
For details and further investigation, click here
