CALD1

 

Full name: caldesmon 1 Alias Symbol: CDM|H-CAD|L-CAD
Type: protein-coding gene Cytoband: 7q33
Entrez ID: 800 HGNC ID: HGNC:1441 Ensembl Gene: ENSG00000122786 OMIM ID: 114213
Drug and gene relationship at DGIdb

 

CALD1 involved pathways:

KEGG pathway Description View
hsa04270Vascular smooth muscle contraction

 

Expression of CALD1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CALD1 800 212077_at -0.5345 0.4214
GSE20347 CALD1 800 212077_at 0.3761 0.3447
GSE23400 CALD1 800 212077_at 0.0246 0.9031
GSE26886 CALD1 800 212077_at 1.5210 0.0007
GSE29001 CALD1 800 212077_at 0.4125 0.1585
GSE38129 CALD1 800 212077_at 0.0434 0.9186
GSE45670 CALD1 800 212077_at -1.3956 0.0002
GSE53622 CALD1 800 14475 -0.1506 0.3651
GSE53624 CALD1 800 5689 0.2286 0.0223
GSE63941 CALD1 800 212077_at -4.1858 0.0026
GSE77861 CALD1 800 212077_at 1.6342 0.0072
GSE97050 CALD1 800 A_24_P921366 -0.9711 0.1187
SRP007169 CALD1 800 RNAseq 3.2669 0.0000
SRP008496 CALD1 800 RNAseq 3.5058 0.0000
SRP064894 CALD1 800 RNAseq 0.3508 0.2460
SRP133303 CALD1 800 RNAseq 0.6288 0.1385
SRP159526 CALD1 800 RNAseq -0.5740 0.1792
SRP193095 CALD1 800 RNAseq 1.6276 0.0000
SRP219564 CALD1 800 RNAseq -0.4939 0.5781
TCGA CALD1 800 RNAseq -0.2472 0.0044

Upregulated datasets: 5; Downregulated datasets: 2.  

 

Survival by CALD1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CALD1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CALD1 800 6 2 22
GSE20123 CALD1 800 6 2 22
GSE43470 CALD1 800 2 3 38
GSE46452 CALD1 800 7 2 50
GSE47630 CALD1 800 7 4 29
GSE54993 CALD1 800 3 5 62
GSE54994 CALD1 800 6 8 39
GSE60625 CALD1 800 0 0 11
GSE74703 CALD1 800 2 3 31
GSE74704 CALD1 800 2 2 16
TCGA CALD1 800 29 23 44

Total number of gains: 70; Total number of losses: 54; Total Number of normals: 364.  

 

Somatic mutations of CALD1:

 

Generating mutation plots.

 

Highly correlated genes for CALD1:

 

Showing top 20/1000 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CALD1TPM10.82866613012
CALD1FERMT20.82636413013
CALD1LAMA40.8187312012
CALD1ZEB10.809301303
CALD1TPM20.80030413013
CALD1FBN10.79666611011
CALD1FILIP1L0.7958213013
CALD1PMP220.79195212012
CALD1TGFB1I10.78392513012
CALD1ACTA20.77912913012
CALD1ANTXR20.767304909
CALD1FN10.7658811010
CALD1PDLIM30.76561913012
CALD1SYNC0.763706808
CALD1DDR20.76316912012
CALD1PALLD0.75928913011
CALD1DCN0.75608112012
CALD1MAP1B0.75571811010
CALD1TMEM470.75397813011
CALD1LINC012790.752835404

For details and further investigation, click here