| Full name: collagen type VI alpha 1 chain | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 21q22.3 | ||
| Entrez ID: 1291 | HGNC ID: HGNC:2211 | Ensembl Gene: ENSG00000142156 | OMIM ID: 120220 |
| Drug and gene relationship at DGIdb | |||
COL6A1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion |
Expression of COL6A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COL6A1 | 1291 | 213428_s_at | -0.0277 | 0.9834 | |
| GSE20347 | COL6A1 | 1291 | 213428_s_at | 0.8504 | 0.0161 | |
| GSE23400 | COL6A1 | 1291 | 213428_s_at | 0.3612 | 0.0336 | |
| GSE26886 | COL6A1 | 1291 | 213428_s_at | 2.0375 | 0.0001 | |
| GSE29001 | COL6A1 | 1291 | 213428_s_at | 0.8142 | 0.0297 | |
| GSE38129 | COL6A1 | 1291 | 213428_s_at | 0.3568 | 0.3998 | |
| GSE45670 | COL6A1 | 1291 | 213428_s_at | -0.8430 | 0.1015 | |
| GSE53622 | COL6A1 | 1291 | 65495 | 1.3811 | 0.0000 | |
| GSE53624 | COL6A1 | 1291 | 65495 | 1.5430 | 0.0000 | |
| GSE63941 | COL6A1 | 1291 | 213428_s_at | -5.4279 | 0.0002 | |
| GSE77861 | COL6A1 | 1291 | 213428_s_at | 1.1778 | 0.0773 | |
| GSE97050 | COL6A1 | 1291 | A_32_P32254 | 0.4450 | 0.3083 | |
| SRP007169 | COL6A1 | 1291 | RNAseq | 2.9683 | 0.0000 | |
| SRP008496 | COL6A1 | 1291 | RNAseq | 3.5918 | 0.0000 | |
| SRP064894 | COL6A1 | 1291 | RNAseq | 1.0646 | 0.0003 | |
| SRP133303 | COL6A1 | 1291 | RNAseq | 1.3262 | 0.0019 | |
| SRP159526 | COL6A1 | 1291 | RNAseq | -0.0175 | 0.9502 | |
| SRP193095 | COL6A1 | 1291 | RNAseq | 2.8330 | 0.0000 | |
| SRP219564 | COL6A1 | 1291 | RNAseq | -0.0736 | 0.9146 | |
| TCGA | COL6A1 | 1291 | RNAseq | 0.0921 | 0.3262 |
Upregulated datasets: 8; Downregulated datasets: 1.
Survival by COL6A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COL6A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COL6A1 | 1291 | 3 | 9 | 18 | |
| GSE20123 | COL6A1 | 1291 | 3 | 9 | 18 | |
| GSE43470 | COL6A1 | 1291 | 0 | 14 | 29 | |
| GSE46452 | COL6A1 | 1291 | 1 | 21 | 37 | |
| GSE47630 | COL6A1 | 1291 | 6 | 17 | 17 | |
| GSE54993 | COL6A1 | 1291 | 8 | 1 | 61 | |
| GSE54994 | COL6A1 | 1291 | 5 | 8 | 40 | |
| GSE60625 | COL6A1 | 1291 | 0 | 0 | 11 | |
| GSE74703 | COL6A1 | 1291 | 0 | 10 | 26 | |
| GSE74704 | COL6A1 | 1291 | 1 | 5 | 14 | |
| TCGA | COL6A1 | 1291 | 10 | 38 | 48 |
Total number of gains: 37; Total number of losses: 132; Total Number of normals: 319.
Somatic mutations of COL6A1:
Generating mutation plots.
Highly correlated genes for COL6A1:
Showing top 20/1174 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COL6A1 | COL6A2 | 0.916131 | 13 | 0 | 13 |
| COL6A1 | COL12A1 | 0.854825 | 9 | 0 | 9 |
| COL6A1 | COL6A3 | 0.823937 | 13 | 0 | 13 |
| COL6A1 | AEBP1 | 0.813407 | 13 | 0 | 13 |
| COL6A1 | ISLR | 0.804856 | 13 | 0 | 13 |
| COL6A1 | SPARC | 0.804144 | 13 | 0 | 13 |
| COL6A1 | PCOLCE | 0.803714 | 13 | 0 | 13 |
| COL6A1 | FN1 | 0.802004 | 12 | 0 | 11 |
| COL6A1 | COL5A1 | 0.80142 | 13 | 0 | 13 |
| COL6A1 | HTRA1 | 0.793083 | 13 | 0 | 13 |
| COL6A1 | CHN1 | 0.789546 | 13 | 0 | 13 |
| COL6A1 | ANGPTL2 | 0.788858 | 13 | 0 | 12 |
| COL6A1 | CTSK | 0.786808 | 13 | 0 | 13 |
| COL6A1 | LAMA4 | 0.783992 | 12 | 0 | 12 |
| COL6A1 | EFEMP2 | 0.782477 | 13 | 0 | 13 |
| COL6A1 | MMP2 | 0.781775 | 12 | 0 | 11 |
| COL6A1 | PDGFRB | 0.780289 | 13 | 0 | 12 |
| COL6A1 | COL8A1 | 0.779612 | 10 | 0 | 10 |
| COL6A1 | FBN1 | 0.772609 | 11 | 0 | 10 |
| COL6A1 | FSTL1 | 0.766936 | 13 | 0 | 12 |
For details and further investigation, click here
