| Full name: insulin like growth factor binding protein 7 | Alias Symbol: MAC25|IGFBP-7|PSF|FSTL2 | ||
| Type: protein-coding gene | Cytoband: 4q12 | ||
| Entrez ID: 3490 | HGNC ID: HGNC:5476 | Ensembl Gene: ENSG00000163453 | OMIM ID: 602867 |
| Drug and gene relationship at DGIdb | |||
Expression of IGFBP7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IGFBP7 | 3490 | 201163_s_at | 0.0219 | 0.9728 | |
| GSE20347 | IGFBP7 | 3490 | 201163_s_at | 1.1740 | 0.0001 | |
| GSE23400 | IGFBP7 | 3490 | 201162_at | 0.7800 | 0.0002 | |
| GSE26886 | IGFBP7 | 3490 | 201163_s_at | 1.9994 | 0.0001 | |
| GSE29001 | IGFBP7 | 3490 | 201163_s_at | 0.6295 | 0.0958 | |
| GSE38129 | IGFBP7 | 3490 | 201163_s_at | 0.6670 | 0.0222 | |
| GSE45670 | IGFBP7 | 3490 | 201163_s_at | -0.5003 | 0.3014 | |
| GSE53622 | IGFBP7 | 3490 | 71005 | 0.9450 | 0.0000 | |
| GSE53624 | IGFBP7 | 3490 | 58083 | 0.9993 | 0.0000 | |
| GSE63941 | IGFBP7 | 3490 | 201163_s_at | -3.0654 | 0.1684 | |
| GSE77861 | IGFBP7 | 3490 | 201162_at | 1.5686 | 0.0039 | |
| GSE97050 | IGFBP7 | 3490 | A_23_P353035 | 0.7563 | 0.1755 | |
| SRP007169 | IGFBP7 | 3490 | RNAseq | 2.5245 | 0.0000 | |
| SRP008496 | IGFBP7 | 3490 | RNAseq | 2.9047 | 0.0000 | |
| SRP064894 | IGFBP7 | 3490 | RNAseq | 1.4869 | 0.0000 | |
| SRP133303 | IGFBP7 | 3490 | RNAseq | 0.8909 | 0.0007 | |
| SRP159526 | IGFBP7 | 3490 | RNAseq | 0.8858 | 0.0217 | |
| SRP193095 | IGFBP7 | 3490 | RNAseq | 1.8337 | 0.0000 | |
| SRP219564 | IGFBP7 | 3490 | RNAseq | 0.2584 | 0.7669 | |
| TCGA | IGFBP7 | 3490 | RNAseq | 0.0418 | 0.5860 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by IGFBP7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IGFBP7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IGFBP7 | 3490 | 3 | 12 | 15 | |
| GSE20123 | IGFBP7 | 3490 | 2 | 12 | 16 | |
| GSE43470 | IGFBP7 | 3490 | 0 | 14 | 29 | |
| GSE46452 | IGFBP7 | 3490 | 1 | 36 | 22 | |
| GSE47630 | IGFBP7 | 3490 | 0 | 19 | 21 | |
| GSE54993 | IGFBP7 | 3490 | 7 | 0 | 63 | |
| GSE54994 | IGFBP7 | 3490 | 3 | 11 | 39 | |
| GSE60625 | IGFBP7 | 3490 | 0 | 0 | 11 | |
| GSE74703 | IGFBP7 | 3490 | 0 | 12 | 24 | |
| GSE74704 | IGFBP7 | 3490 | 1 | 7 | 12 | |
| TCGA | IGFBP7 | 3490 | 20 | 26 | 50 |
Total number of gains: 37; Total number of losses: 149; Total Number of normals: 302.
Somatic mutations of IGFBP7:
Generating mutation plots.
Highly correlated genes for IGFBP7:
Showing top 20/1362 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IGFBP7 | FSTL1 | 0.816114 | 13 | 0 | 12 |
| IGFBP7 | COL4A2 | 0.797014 | 12 | 0 | 12 |
| IGFBP7 | LAMC1 | 0.78992 | 13 | 0 | 12 |
| IGFBP7 | LAMA4 | 0.774431 | 12 | 0 | 11 |
| IGFBP7 | VCAN | 0.770579 | 12 | 0 | 12 |
| IGFBP7 | LGALS1 | 0.76413 | 12 | 0 | 11 |
| IGFBP7 | COL12A1 | 0.760155 | 9 | 0 | 8 |
| IGFBP7 | RILPL1 | 0.759659 | 3 | 0 | 3 |
| IGFBP7 | CLIC4 | 0.758071 | 12 | 0 | 10 |
| IGFBP7 | FBN1 | 0.755582 | 11 | 0 | 9 |
| IGFBP7 | FN1 | 0.748332 | 12 | 0 | 11 |
| IGFBP7 | ALKBH6 | 0.746249 | 3 | 0 | 3 |
| IGFBP7 | EFEMP2 | 0.743426 | 11 | 0 | 10 |
| IGFBP7 | SPARC | 0.74092 | 13 | 0 | 13 |
| IGFBP7 | COL4A1 | 0.738013 | 12 | 0 | 11 |
| IGFBP7 | MMD | 0.732029 | 13 | 0 | 12 |
| IGFBP7 | CHST15 | 0.730646 | 12 | 0 | 11 |
| IGFBP7 | COL6A2 | 0.729474 | 12 | 0 | 10 |
| IGFBP7 | AEBP1 | 0.728994 | 12 | 0 | 10 |
| IGFBP7 | GLIS2 | 0.72859 | 7 | 0 | 7 |
For details and further investigation, click here
