ITGB1

 

Full name: integrin subunit beta 1 Alias Symbol: CD29|GPIIA
Type: protein-coding gene Cytoband: 10p11.22
Entrez ID: 3688 HGNC ID: HGNC:6153 Ensembl Gene: ENSG00000150093 OMIM ID: 135630
Drug and gene relationship at DGIdb
Screen Evidence:

 

ITGB1 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04360Axon guidance
hsa04510Focal adhesion
hsa04611Platelet activation
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa05100Bacterial invasion of epithelial cells
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05222Small cell lung cancer

 

Expression of ITGB1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ITGB1 3688 211945_s_at 0.3062 0.4806
GSE20347 ITGB1 3688 211945_s_at 0.7767 0.0002
GSE23400 ITGB1 3688 211945_s_at 0.5736 0.0000
GSE26886 ITGB1 3688 211945_s_at 0.6966 0.0001
GSE29001 ITGB1 3688 211945_s_at 0.4177 0.0744
GSE38129 ITGB1 3688 211945_s_at 0.4078 0.0585
GSE45670 ITGB1 3688 211945_s_at -0.0742 0.8156
GSE53622 ITGB1 3688 56043 0.7088 0.0000
GSE53624 ITGB1 3688 56043 0.8769 0.0000
GSE63941 ITGB1 3688 211945_s_at -1.4104 0.0019
GSE77861 ITGB1 3688 211945_s_at 0.6386 0.1426
GSE97050 ITGB1 3688 A_23_P104199 0.1582 0.5191
SRP007169 ITGB1 3688 RNAseq 0.9105 0.0066
SRP008496 ITGB1 3688 RNAseq 1.6253 0.0000
SRP064894 ITGB1 3688 RNAseq 0.7853 0.0012
SRP133303 ITGB1 3688 RNAseq 1.1455 0.0000
SRP159526 ITGB1 3688 RNAseq 0.4086 0.2883
SRP193095 ITGB1 3688 RNAseq 0.9351 0.0000
SRP219564 ITGB1 3688 RNAseq -0.0220 0.9737
TCGA ITGB1 3688 RNAseq 0.0190 0.7229

Upregulated datasets: 2; Downregulated datasets: 1.  

 

Survival by ITGB1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ITGB1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ITGB1 3688 5 7 18
GSE20123 ITGB1 3688 5 6 19
GSE43470 ITGB1 3688 4 3 36
GSE46452 ITGB1 3688 1 14 44
GSE47630 ITGB1 3688 5 15 20
GSE54993 ITGB1 3688 9 0 61
GSE54994 ITGB1 3688 3 8 42
GSE60625 ITGB1 3688 0 0 11
GSE74703 ITGB1 3688 2 2 32
GSE74704 ITGB1 3688 0 5 15
TCGA ITGB1 3688 16 24 56

Total number of gains: 50; Total number of losses: 84; Total Number of normals: 354.  

 

Somatic mutations of ITGB1:

 

Generating mutation plots.

 

Highly correlated genes for ITGB1:

 

Showing top 20/1376 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ITGB1RAB340.817215303
ITGB1LAMC10.78613113013
ITGB1MICAL20.783847909
ITGB1FGF70.756274303
ITGB1C11orf960.746804403
ITGB1LTBP10.74440412012
ITGB1TMEM2630.736175707
ITGB1LGALS10.73608513012
ITGB1FBN10.73281610010
ITGB1LRRC8C0.730064303
ITGB1CALU0.72839412012
ITGB1FILIP10.725203303
ITGB1HTRA10.72462513013
ITGB1CLIC40.72441213011
ITGB1GLIS20.722162707
ITGB1FSTL10.72205513013
ITGB1RHOBTB10.72179813013
ITGB1CEP1700.721449303
ITGB1FKBP70.71935808
ITGB1RFTN10.71457312011

For details and further investigation, click here