LTBP1

 

Full name: latent transforming growth factor beta binding protein 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 2p22.3
Entrez ID: 4052 HGNC ID: HGNC:6714 Ensembl Gene: ENSG00000049323 OMIM ID: 150390
Drug and gene relationship at DGIdb

 

LTBP1 involved pathways:

KEGG pathway Description View
hsa04350TGF-beta signaling pathway

 

Expression of LTBP1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 LTBP1 4052 202729_s_at 0.3086 0.7363
GSE20347 LTBP1 4052 202729_s_at 0.9207 0.0036
GSE23400 LTBP1 4052 202729_s_at 0.7063 0.0000
GSE26886 LTBP1 4052 202729_s_at 2.6792 0.0000
GSE29001 LTBP1 4052 202729_s_at 1.2752 0.0071
GSE38129 LTBP1 4052 202729_s_at 0.3604 0.3158
GSE45670 LTBP1 4052 202729_s_at -0.1306 0.8179
GSE53622 LTBP1 4052 78852 0.5985 0.0001
GSE53624 LTBP1 4052 167549 0.8693 0.0000
GSE63941 LTBP1 4052 202729_s_at -3.5760 0.0001
GSE77861 LTBP1 4052 202729_s_at 1.2630 0.0619
GSE97050 LTBP1 4052 A_33_P3304655 -0.4745 0.2737
SRP007169 LTBP1 4052 RNAseq 3.0624 0.0000
SRP008496 LTBP1 4052 RNAseq 2.9867 0.0000
SRP064894 LTBP1 4052 RNAseq 1.5327 0.0000
SRP133303 LTBP1 4052 RNAseq 1.1959 0.0020
SRP159526 LTBP1 4052 RNAseq 0.4577 0.3740
SRP193095 LTBP1 4052 RNAseq 2.1316 0.0000
SRP219564 LTBP1 4052 RNAseq 0.6584 0.3730
TCGA LTBP1 4052 RNAseq -0.0368 0.7185

Upregulated datasets: 7; Downregulated datasets: 1.  

 

Survival by LTBP1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of LTBP1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 LTBP1 4052 10 1 19
GSE20123 LTBP1 4052 9 1 20
GSE43470 LTBP1 4052 3 1 39
GSE46452 LTBP1 4052 2 4 53
GSE47630 LTBP1 4052 8 0 32
GSE54993 LTBP1 4052 0 5 65
GSE54994 LTBP1 4052 10 0 43
GSE60625 LTBP1 4052 0 3 8
GSE74703 LTBP1 4052 3 0 33
GSE74704 LTBP1 4052 9 1 10
TCGA LTBP1 4052 36 3 57

Total number of gains: 90; Total number of losses: 19; Total Number of normals: 379.  

 

Somatic mutations of LTBP1:

 

Generating mutation plots.

 

Highly correlated genes for LTBP1:

 

Showing top 20/1295 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
LTBP1RILPL10.788042404
LTBP1FGF70.784509303
LTBP1BHMT20.763578303
LTBP1SEMA3C0.76113811011
LTBP1C11orf960.75602403
LTBP1FBN10.749438909
LTBP1TNFRSF190.749366303
LTBP1FNIP20.746653303
LTBP1ITGB10.74440412012
LTBP1LAMC10.74404212011
LTBP1IGFBP50.735694404
LTBP1NPHP30.722344303
LTBP1FRY0.721882403
LTBP1EFEMP20.72167212012
LTBP1FAM98B0.721156303
LTBP1SLC39A130.719955707
LTBP1FSTL10.71895612012
LTBP1PEG30.718402303
LTBP1CELF20.717054303
LTBP1IGFBP70.7164211011

For details and further investigation, click here