| Full name: aldehyde dehydrogenase 5 family member A1 | Alias Symbol: SSADH|SSDH | ||
| Type: protein-coding gene | Cytoband: 6p22.3 | ||
| Entrez ID: 7915 | HGNC ID: HGNC:408 | Ensembl Gene: ENSG00000112294 | OMIM ID: 610045 |
| Drug and gene relationship at DGIdb | |||
Expression of ALDH5A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALDH5A1 | 7915 | 203608_at | 0.8702 | 0.2008 | |
| GSE20347 | ALDH5A1 | 7915 | 203608_at | 0.0795 | 0.8366 | |
| GSE23400 | ALDH5A1 | 7915 | 203608_at | 0.3016 | 0.0288 | |
| GSE26886 | ALDH5A1 | 7915 | 203608_at | 0.3208 | 0.6131 | |
| GSE29001 | ALDH5A1 | 7915 | 203608_at | -0.0670 | 0.9026 | |
| GSE38129 | ALDH5A1 | 7915 | 203608_at | 0.3011 | 0.2532 | |
| GSE45670 | ALDH5A1 | 7915 | 203608_at | -0.2555 | 0.5487 | |
| GSE53622 | ALDH5A1 | 7915 | 41465 | -0.0852 | 0.6192 | |
| GSE53624 | ALDH5A1 | 7915 | 41465 | -0.3960 | 0.0017 | |
| GSE63941 | ALDH5A1 | 7915 | 203608_at | 1.7431 | 0.0254 | |
| GSE77861 | ALDH5A1 | 7915 | 203608_at | -0.2048 | 0.7086 | |
| GSE97050 | ALDH5A1 | 7915 | A_24_P115007 | 0.1714 | 0.5824 | |
| SRP007169 | ALDH5A1 | 7915 | RNAseq | 0.9867 | 0.0686 | |
| SRP008496 | ALDH5A1 | 7915 | RNAseq | 0.9830 | 0.0174 | |
| SRP064894 | ALDH5A1 | 7915 | RNAseq | -0.2473 | 0.3379 | |
| SRP133303 | ALDH5A1 | 7915 | RNAseq | -0.3924 | 0.0437 | |
| SRP159526 | ALDH5A1 | 7915 | RNAseq | 0.4948 | 0.2644 | |
| SRP193095 | ALDH5A1 | 7915 | RNAseq | -0.2255 | 0.1531 | |
| SRP219564 | ALDH5A1 | 7915 | RNAseq | 0.6988 | 0.2823 | |
| TCGA | ALDH5A1 | 7915 | RNAseq | -0.1040 | 0.4070 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ALDH5A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALDH5A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALDH5A1 | 7915 | 4 | 2 | 24 | |
| GSE20123 | ALDH5A1 | 7915 | 4 | 2 | 24 | |
| GSE43470 | ALDH5A1 | 7915 | 5 | 0 | 38 | |
| GSE46452 | ALDH5A1 | 7915 | 1 | 9 | 49 | |
| GSE47630 | ALDH5A1 | 7915 | 8 | 5 | 27 | |
| GSE54993 | ALDH5A1 | 7915 | 1 | 1 | 68 | |
| GSE54994 | ALDH5A1 | 7915 | 10 | 4 | 39 | |
| GSE60625 | ALDH5A1 | 7915 | 0 | 1 | 10 | |
| GSE74703 | ALDH5A1 | 7915 | 5 | 0 | 31 | |
| GSE74704 | ALDH5A1 | 7915 | 1 | 1 | 18 | |
| TCGA | ALDH5A1 | 7915 | 17 | 21 | 58 |
Total number of gains: 56; Total number of losses: 46; Total Number of normals: 386.
Somatic mutations of ALDH5A1:
Generating mutation plots.
Highly correlated genes for ALDH5A1:
Showing top 20/307 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALDH5A1 | SGPL1 | 0.775717 | 3 | 0 | 3 |
| ALDH5A1 | PRCC | 0.768232 | 3 | 0 | 3 |
| ALDH5A1 | SLC25A1 | 0.766527 | 3 | 0 | 3 |
| ALDH5A1 | PTPRF | 0.757186 | 3 | 0 | 3 |
| ALDH5A1 | MRPL51 | 0.745857 | 3 | 0 | 3 |
| ALDH5A1 | ERCC6 | 0.728433 | 3 | 0 | 3 |
| ALDH5A1 | TNK1 | 0.728033 | 3 | 0 | 3 |
| ALDH5A1 | NDUFA9 | 0.726716 | 3 | 0 | 3 |
| ALDH5A1 | EFTUD2 | 0.724454 | 3 | 0 | 3 |
| ALDH5A1 | CXCL16 | 0.716317 | 3 | 0 | 3 |
| ALDH5A1 | LAMTOR1 | 0.712114 | 3 | 0 | 3 |
| ALDH5A1 | LMLN | 0.710521 | 3 | 0 | 3 |
| ALDH5A1 | KIF20B | 0.707545 | 3 | 0 | 3 |
| ALDH5A1 | PARG | 0.707132 | 3 | 0 | 3 |
| ALDH5A1 | WARS2 | 0.706889 | 3 | 0 | 3 |
| ALDH5A1 | MEN1 | 0.706387 | 3 | 0 | 3 |
| ALDH5A1 | TRAP1 | 0.703819 | 3 | 0 | 3 |
| ALDH5A1 | ZNRF3 | 0.702302 | 3 | 0 | 3 |
| ALDH5A1 | VPS52 | 0.699885 | 3 | 0 | 3 |
| ALDH5A1 | ALG3 | 0.69964 | 3 | 0 | 3 |
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