| Full name: lactate dehydrogenase D | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16q23.1 | ||
| Entrez ID: 197257 | HGNC ID: HGNC:19708 | Ensembl Gene: ENSG00000166816 | OMIM ID: 607490 |
| Drug and gene relationship at DGIdb | |||
Expression of LDHD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LDHD | 197257 | 229241_at | -0.7986 | 0.1640 | |
| GSE26886 | LDHD | 197257 | 229241_at | -0.8950 | 0.0000 | |
| GSE45670 | LDHD | 197257 | 229241_at | -0.0962 | 0.7391 | |
| GSE53622 | LDHD | 197257 | 13432 | -1.9466 | 0.0000 | |
| GSE53624 | LDHD | 197257 | 13432 | -1.9484 | 0.0000 | |
| GSE63941 | LDHD | 197257 | 229241_at | 0.0371 | 0.8933 | |
| GSE77861 | LDHD | 197257 | 229241_at | -0.2025 | 0.3579 | |
| GSE97050 | LDHD | 197257 | A_23_P54918 | -0.6228 | 0.1623 | |
| SRP007169 | LDHD | 197257 | RNAseq | -3.0461 | 0.0000 | |
| SRP008496 | LDHD | 197257 | RNAseq | -3.2214 | 0.0000 | |
| SRP064894 | LDHD | 197257 | RNAseq | -1.8348 | 0.0000 | |
| SRP133303 | LDHD | 197257 | RNAseq | -1.0808 | 0.0137 | |
| SRP159526 | LDHD | 197257 | RNAseq | -1.4087 | 0.0725 | |
| SRP193095 | LDHD | 197257 | RNAseq | -1.6903 | 0.0000 | |
| SRP219564 | LDHD | 197257 | RNAseq | -2.3438 | 0.0000 | |
| TCGA | LDHD | 197257 | RNAseq | -1.1228 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by LDHD expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LDHD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LDHD | 197257 | 6 | 1 | 23 | |
| GSE20123 | LDHD | 197257 | 6 | 1 | 23 | |
| GSE43470 | LDHD | 197257 | 2 | 8 | 33 | |
| GSE46452 | LDHD | 197257 | 37 | 2 | 20 | |
| GSE47630 | LDHD | 197257 | 11 | 8 | 21 | |
| GSE54993 | LDHD | 197257 | 2 | 4 | 64 | |
| GSE54994 | LDHD | 197257 | 8 | 10 | 35 | |
| GSE60625 | LDHD | 197257 | 4 | 0 | 7 | |
| GSE74703 | LDHD | 197257 | 2 | 5 | 29 | |
| GSE74704 | LDHD | 197257 | 3 | 0 | 17 | |
| TCGA | LDHD | 197257 | 25 | 15 | 56 |
Total number of gains: 106; Total number of losses: 54; Total Number of normals: 328.
Somatic mutations of LDHD:
Generating mutation plots.
Highly correlated genes for LDHD:
Showing top 20/1349 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LDHD | GLTP | 0.805913 | 4 | 0 | 4 |
| LDHD | NLRX1 | 0.791058 | 6 | 0 | 6 |
| LDHD | GLCE | 0.767625 | 3 | 0 | 3 |
| LDHD | CSTA | 0.766164 | 3 | 0 | 3 |
| LDHD | PRSS2 | 0.762666 | 3 | 0 | 3 |
| LDHD | VPS4B | 0.760252 | 6 | 0 | 6 |
| LDHD | ANXA9 | 0.755606 | 6 | 0 | 6 |
| LDHD | GDPD3 | 0.750569 | 5 | 0 | 5 |
| LDHD | LRRC20 | 0.748288 | 4 | 0 | 4 |
| LDHD | TPM4 | 0.74412 | 3 | 0 | 3 |
| LDHD | CYP2C19 | 0.738419 | 4 | 0 | 4 |
| LDHD | SCNN1B | 0.737082 | 7 | 0 | 7 |
| LDHD | CYP2C18 | 0.736301 | 5 | 0 | 5 |
| LDHD | ANKRD37 | 0.735472 | 4 | 0 | 3 |
| LDHD | MAB21L3 | 0.732602 | 5 | 0 | 5 |
| LDHD | MXD1 | 0.732073 | 5 | 0 | 5 |
| LDHD | ABHD5 | 0.726908 | 6 | 0 | 6 |
| LDHD | KCMF1 | 0.726173 | 3 | 0 | 3 |
| LDHD | CCNYL1 | 0.72294 | 5 | 0 | 4 |
| LDHD | RMND5B | 0.722139 | 7 | 0 | 7 |
For details and further investigation, click here
