| Full name: cytochrome P450 family 2 subfamily C member 19 | Alias Symbol: P450IIC19|CPCJ | ||
| Type: protein-coding gene | Cytoband: 10q23.33 | ||
| Entrez ID: 1557 | HGNC ID: HGNC:2621 | Ensembl Gene: ENSG00000165841 | OMIM ID: 124020 |
| Drug and gene relationship at DGIdb | |||
Expression of CYP2C19:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYP2C19 | 1557 | 216058_s_at | -0.5093 | 0.1818 | |
| GSE20347 | CYP2C19 | 1557 | 216058_s_at | -0.1235 | 0.2758 | |
| GSE23400 | CYP2C19 | 1557 | 216058_s_at | -0.1822 | 0.0000 | |
| GSE26886 | CYP2C19 | 1557 | 216058_s_at | -0.8288 | 0.0001 | |
| GSE29001 | CYP2C19 | 1557 | 216058_s_at | -1.0816 | 0.0003 | |
| GSE38129 | CYP2C19 | 1557 | 216058_s_at | -0.2551 | 0.0109 | |
| GSE45670 | CYP2C19 | 1557 | 216058_s_at | -0.0971 | 0.7330 | |
| GSE63941 | CYP2C19 | 1557 | 216058_s_at | 0.0875 | 0.4319 | |
| GSE77861 | CYP2C19 | 1557 | 216058_s_at | -0.1025 | 0.3440 | |
| GSE97050 | CYP2C19 | 1557 | A_33_P3326075 | -0.1539 | 0.5096 | |
| SRP007169 | CYP2C19 | 1557 | RNAseq | -3.0689 | 0.0000 | |
| SRP064894 | CYP2C19 | 1557 | RNAseq | -2.5177 | 0.0000 | |
| SRP133303 | CYP2C19 | 1557 | RNAseq | -2.0437 | 0.0000 | |
| SRP159526 | CYP2C19 | 1557 | RNAseq | -3.9551 | 0.0000 | |
| SRP193095 | CYP2C19 | 1557 | RNAseq | -1.8559 | 0.0000 | |
| SRP219564 | CYP2C19 | 1557 | RNAseq | -3.0181 | 0.0002 | |
| TCGA | CYP2C19 | 1557 | RNAseq | -1.6326 | 0.0471 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by CYP2C19 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CYP2C19:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP2C19 | 1557 | 1 | 8 | 21 | |
| GSE20123 | CYP2C19 | 1557 | 1 | 7 | 22 | |
| GSE43470 | CYP2C19 | 1557 | 0 | 7 | 36 | |
| GSE46452 | CYP2C19 | 1557 | 0 | 11 | 48 | |
| GSE47630 | CYP2C19 | 1557 | 2 | 14 | 24 | |
| GSE54993 | CYP2C19 | 1557 | 7 | 0 | 63 | |
| GSE54994 | CYP2C19 | 1557 | 2 | 10 | 41 | |
| GSE60625 | CYP2C19 | 1557 | 0 | 0 | 11 | |
| GSE74703 | CYP2C19 | 1557 | 0 | 5 | 31 | |
| GSE74704 | CYP2C19 | 1557 | 0 | 4 | 16 | |
| TCGA | CYP2C19 | 1557 | 6 | 26 | 64 |
Total number of gains: 19; Total number of losses: 92; Total Number of normals: 377.
Somatic mutations of CYP2C19:
Generating mutation plots.
Highly correlated genes for CYP2C19:
Showing top 20/1069 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP2C19 | GNAI3 | 0.77285 | 3 | 0 | 3 |
| CYP2C19 | FAM47A | 0.76329 | 3 | 0 | 3 |
| CYP2C19 | CANT1 | 0.751549 | 3 | 0 | 3 |
| CYP2C19 | PNPLA8 | 0.747567 | 3 | 0 | 3 |
| CYP2C19 | LDHD | 0.738419 | 4 | 0 | 4 |
| CYP2C19 | CWC25 | 0.730854 | 3 | 0 | 3 |
| CYP2C19 | SHB | 0.728664 | 3 | 0 | 3 |
| CYP2C19 | CHIC2 | 0.728594 | 5 | 0 | 5 |
| CYP2C19 | TAB3 | 0.725962 | 4 | 0 | 4 |
| CYP2C19 | ESYT2 | 0.725932 | 3 | 0 | 3 |
| CYP2C19 | TBC1D20 | 0.72523 | 3 | 0 | 3 |
| CYP2C19 | SLC16A14 | 0.724654 | 3 | 0 | 3 |
| CYP2C19 | SH3PXD2A-AS1 | 0.720964 | 3 | 0 | 3 |
| CYP2C19 | DNAJA2 | 0.720393 | 3 | 0 | 3 |
| CYP2C19 | FBXO42 | 0.719205 | 4 | 0 | 4 |
| CYP2C19 | TOM1L1 | 0.709935 | 4 | 0 | 3 |
| CYP2C19 | SLC16A9 | 0.708915 | 3 | 0 | 3 |
| CYP2C19 | RDH12 | 0.70837 | 3 | 0 | 3 |
| CYP2C19 | SOCS2 | 0.706299 | 3 | 0 | 3 |
| CYP2C19 | CCNDBP1 | 0.704072 | 4 | 0 | 4 |
For details and further investigation, click here
