| Full name: abhydrolase domain containing 5 | Alias Symbol: CGI-58|NCIE2 | ||
| Type: protein-coding gene | Cytoband: 3p21.33 | ||
| Entrez ID: 51099 | HGNC ID: HGNC:21396 | Ensembl Gene: ENSG00000011198 | OMIM ID: 604780 |
| Drug and gene relationship at DGIdb | |||
ABHD5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04923 | Regulation of lipolysis in adipocytes |
Expression of ABHD5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ABHD5 | 51099 | 218739_at | -0.6088 | 0.1951 | |
| GSE20347 | ABHD5 | 51099 | 218739_at | -1.9680 | 0.0000 | |
| GSE23400 | ABHD5 | 51099 | 218739_at | -1.4359 | 0.0000 | |
| GSE26886 | ABHD5 | 51099 | 218739_at | -2.8059 | 0.0000 | |
| GSE29001 | ABHD5 | 51099 | 213935_at | -0.9964 | 0.0155 | |
| GSE38129 | ABHD5 | 51099 | 218739_at | -1.5491 | 0.0000 | |
| GSE45670 | ABHD5 | 51099 | 218739_at | -1.0181 | 0.0062 | |
| GSE53622 | ABHD5 | 51099 | 36719 | -1.2223 | 0.0000 | |
| GSE53624 | ABHD5 | 51099 | 36719 | -1.6043 | 0.0000 | |
| GSE63941 | ABHD5 | 51099 | 218739_at | -1.6265 | 0.0081 | |
| GSE77861 | ABHD5 | 51099 | 218739_at | -1.3043 | 0.0047 | |
| GSE97050 | ABHD5 | 51099 | A_23_P250294 | -0.3211 | 0.2935 | |
| SRP007169 | ABHD5 | 51099 | RNAseq | -3.3346 | 0.0000 | |
| SRP008496 | ABHD5 | 51099 | RNAseq | -3.1927 | 0.0000 | |
| SRP064894 | ABHD5 | 51099 | RNAseq | -2.3318 | 0.0000 | |
| SRP133303 | ABHD5 | 51099 | RNAseq | -1.4039 | 0.0000 | |
| SRP159526 | ABHD5 | 51099 | RNAseq | -1.3661 | 0.0012 | |
| SRP193095 | ABHD5 | 51099 | RNAseq | -2.1157 | 0.0000 | |
| SRP219564 | ABHD5 | 51099 | RNAseq | -1.6162 | 0.0052 | |
| TCGA | ABHD5 | 51099 | RNAseq | -0.2121 | 0.0044 |
Upregulated datasets: 0; Downregulated datasets: 16.
Survival by ABHD5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ABHD5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ABHD5 | 51099 | 0 | 19 | 11 | |
| GSE20123 | ABHD5 | 51099 | 0 | 19 | 11 | |
| GSE43470 | ABHD5 | 51099 | 0 | 21 | 22 | |
| GSE46452 | ABHD5 | 51099 | 2 | 17 | 40 | |
| GSE47630 | ABHD5 | 51099 | 1 | 24 | 15 | |
| GSE54993 | ABHD5 | 51099 | 7 | 2 | 61 | |
| GSE54994 | ABHD5 | 51099 | 1 | 34 | 18 | |
| GSE60625 | ABHD5 | 51099 | 5 | 0 | 6 | |
| GSE74703 | ABHD5 | 51099 | 0 | 16 | 20 | |
| GSE74704 | ABHD5 | 51099 | 0 | 13 | 7 | |
| TCGA | ABHD5 | 51099 | 1 | 72 | 23 |
Total number of gains: 17; Total number of losses: 237; Total Number of normals: 234.
Somatic mutations of ABHD5:
Generating mutation plots.
Highly correlated genes for ABHD5:
Showing top 20/1632 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ABHD5 | SFTA2 | 0.862044 | 4 | 0 | 4 |
| ABHD5 | SPINK7 | 0.845942 | 6 | 0 | 6 |
| ABHD5 | SPNS2 | 0.84283 | 5 | 0 | 5 |
| ABHD5 | TTC9 | 0.840902 | 11 | 0 | 11 |
| ABHD5 | SCEL | 0.839309 | 10 | 0 | 10 |
| ABHD5 | GYS2 | 0.83789 | 10 | 0 | 10 |
| ABHD5 | GDPD3 | 0.835733 | 10 | 0 | 10 |
| ABHD5 | CYSRT1 | 0.83274 | 6 | 0 | 6 |
| ABHD5 | SLC46A2 | 0.831287 | 7 | 0 | 7 |
| ABHD5 | CCNYL1 | 0.828742 | 5 | 0 | 5 |
| ABHD5 | RAB11A | 0.826653 | 11 | 0 | 11 |
| ABHD5 | TMPRSS11B | 0.826306 | 6 | 0 | 6 |
| ABHD5 | VSIG10L | 0.824089 | 6 | 0 | 6 |
| ABHD5 | CA13 | 0.823463 | 3 | 0 | 3 |
| ABHD5 | C18orf25 | 0.821259 | 12 | 0 | 12 |
| ABHD5 | ENDOU | 0.818519 | 11 | 0 | 11 |
| ABHD5 | ZNF823 | 0.816734 | 7 | 0 | 7 |
| ABHD5 | FAM214A | 0.816577 | 6 | 0 | 6 |
| ABHD5 | GRPEL2 | 0.815646 | 7 | 0 | 7 |
| ABHD5 | ATG9B | 0.81474 | 7 | 0 | 7 |
For details and further investigation, click here
