| Full name: leucine zipper and EF-hand containing transmembrane protein 1 | Alias Symbol: SLC55A1 | ||
| Type: protein-coding gene | Cytoband: 4p16.3 | ||
| Entrez ID: 3954 | HGNC ID: HGNC:6556 | Ensembl Gene: ENSG00000168924 | OMIM ID: 604407 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of LETM1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LETM1 | 3954 | 222006_at | 0.7333 | 0.2545 | |
| GSE20347 | LETM1 | 3954 | 222006_at | -0.3836 | 0.0186 | |
| GSE23400 | LETM1 | 3954 | 222006_at | -0.0481 | 0.4401 | |
| GSE26886 | LETM1 | 3954 | 222006_at | -0.1284 | 0.6227 | |
| GSE29001 | LETM1 | 3954 | 222006_at | -0.2818 | 0.1248 | |
| GSE38129 | LETM1 | 3954 | 222006_at | -0.1878 | 0.1774 | |
| GSE45670 | LETM1 | 3954 | 222006_at | 0.1134 | 0.3701 | |
| GSE53622 | LETM1 | 3954 | 48146 | -0.2000 | 0.0207 | |
| GSE53624 | LETM1 | 3954 | 48146 | -0.0876 | 0.2128 | |
| GSE63941 | LETM1 | 3954 | 222006_at | -0.4073 | 0.1162 | |
| GSE77861 | LETM1 | 3954 | 222006_at | -0.1111 | 0.4723 | |
| GSE97050 | LETM1 | 3954 | A_33_P3405022 | 0.1772 | 0.4008 | |
| SRP007169 | LETM1 | 3954 | RNAseq | -0.4175 | 0.2940 | |
| SRP008496 | LETM1 | 3954 | RNAseq | -0.3468 | 0.1989 | |
| SRP064894 | LETM1 | 3954 | RNAseq | -0.1182 | 0.5449 | |
| SRP133303 | LETM1 | 3954 | RNAseq | -0.1901 | 0.1810 | |
| SRP159526 | LETM1 | 3954 | RNAseq | -0.2347 | 0.3492 | |
| SRP193095 | LETM1 | 3954 | RNAseq | -0.4243 | 0.0000 | |
| SRP219564 | LETM1 | 3954 | RNAseq | 0.0610 | 0.9078 | |
| TCGA | LETM1 | 3954 | RNAseq | -0.1074 | 0.0362 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LETM1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LETM1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LETM1 | 3954 | 0 | 16 | 14 | |
| GSE20123 | LETM1 | 3954 | 0 | 16 | 14 | |
| GSE43470 | LETM1 | 3954 | 1 | 16 | 26 | |
| GSE46452 | LETM1 | 3954 | 1 | 36 | 22 | |
| GSE47630 | LETM1 | 3954 | 1 | 19 | 20 | |
| GSE54993 | LETM1 | 3954 | 11 | 0 | 59 | |
| GSE54994 | LETM1 | 3954 | 3 | 12 | 38 | |
| GSE60625 | LETM1 | 3954 | 0 | 0 | 11 | |
| GSE74703 | LETM1 | 3954 | 1 | 12 | 23 | |
| GSE74704 | LETM1 | 3954 | 0 | 8 | 12 | |
| TCGA | LETM1 | 3954 | 9 | 47 | 40 |
Total number of gains: 27; Total number of losses: 182; Total Number of normals: 279.
Somatic mutations of LETM1:
Generating mutation plots.
Highly correlated genes for LETM1:
Showing top 20/223 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LETM1 | EED | 0.756047 | 3 | 0 | 3 |
| LETM1 | ZNF680 | 0.753011 | 3 | 0 | 3 |
| LETM1 | NUDT19 | 0.748433 | 3 | 0 | 3 |
| LETM1 | CCAR1 | 0.731555 | 3 | 0 | 3 |
| LETM1 | PSMD14 | 0.723046 | 3 | 0 | 3 |
| LETM1 | CCDC15 | 0.704363 | 3 | 0 | 3 |
| LETM1 | ARAP1 | 0.702857 | 3 | 0 | 3 |
| LETM1 | RRS1 | 0.701302 | 3 | 0 | 3 |
| LETM1 | EXOSC6 | 0.685531 | 3 | 0 | 3 |
| LETM1 | FKBP2 | 0.68451 | 3 | 0 | 3 |
| LETM1 | ZBTB37 | 0.66171 | 3 | 0 | 3 |
| LETM1 | TTLL4 | 0.654712 | 3 | 0 | 3 |
| LETM1 | NCLN | 0.654416 | 4 | 0 | 3 |
| LETM1 | LTV1 | 0.654191 | 4 | 0 | 3 |
| LETM1 | CPNE8 | 0.653506 | 3 | 0 | 3 |
| LETM1 | GK5 | 0.651604 | 5 | 0 | 5 |
| LETM1 | LYAR | 0.650629 | 3 | 0 | 3 |
| LETM1 | GNL3L | 0.649337 | 3 | 0 | 3 |
| LETM1 | SLC35D1 | 0.647742 | 4 | 0 | 3 |
| LETM1 | KDM2B | 0.645521 | 4 | 0 | 3 |
For details and further investigation, click here
