| Full name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11q13.4 | ||
| Entrez ID: 116985 | HGNC ID: HGNC:16925 | Ensembl Gene: ENSG00000186635 | OMIM ID: 606646 |
| Drug and gene relationship at DGIdb | |||
Expression of ARAP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARAP1 | 116985 | 34206_at | 0.8899 | 0.1133 | |
| GSE20347 | ARAP1 | 116985 | 34206_at | 0.1917 | 0.4237 | |
| GSE23400 | ARAP1 | 116985 | 34206_at | 0.1591 | 0.0088 | |
| GSE26886 | ARAP1 | 116985 | 34206_at | -0.1168 | 0.6168 | |
| GSE29001 | ARAP1 | 116985 | 34206_at | 0.0943 | 0.7754 | |
| GSE38129 | ARAP1 | 116985 | 34206_at | 0.1524 | 0.3837 | |
| GSE45670 | ARAP1 | 116985 | 34206_at | 0.4749 | 0.0192 | |
| GSE53622 | ARAP1 | 116985 | 110346 | 0.2841 | 0.0005 | |
| GSE53624 | ARAP1 | 116985 | 110346 | 0.4609 | 0.0000 | |
| GSE63941 | ARAP1 | 116985 | 34206_at | -0.4143 | 0.3673 | |
| GSE77861 | ARAP1 | 116985 | 34206_at | -0.0934 | 0.6719 | |
| GSE97050 | ARAP1 | 116985 | A_24_P398432 | 0.1766 | 0.5527 | |
| SRP007169 | ARAP1 | 116985 | RNAseq | -0.0098 | 0.9757 | |
| SRP008496 | ARAP1 | 116985 | RNAseq | 0.0588 | 0.8063 | |
| SRP064894 | ARAP1 | 116985 | RNAseq | 0.8592 | 0.0025 | |
| SRP133303 | ARAP1 | 116985 | RNAseq | 0.2692 | 0.3066 | |
| SRP159526 | ARAP1 | 116985 | RNAseq | -0.6280 | 0.0115 | |
| SRP193095 | ARAP1 | 116985 | RNAseq | 0.2776 | 0.0697 | |
| SRP219564 | ARAP1 | 116985 | RNAseq | 0.4200 | 0.1404 | |
| TCGA | ARAP1 | 116985 | RNAseq | 0.0542 | 0.3485 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ARAP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARAP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARAP1 | 116985 | 10 | 6 | 14 | |
| GSE20123 | ARAP1 | 116985 | 9 | 7 | 14 | |
| GSE43470 | ARAP1 | 116985 | 9 | 3 | 31 | |
| GSE46452 | ARAP1 | 116985 | 10 | 19 | 30 | |
| GSE47630 | ARAP1 | 116985 | 9 | 11 | 20 | |
| GSE54993 | ARAP1 | 116985 | 8 | 2 | 60 | |
| GSE54994 | ARAP1 | 116985 | 9 | 15 | 29 | |
| GSE60625 | ARAP1 | 116985 | 0 | 7 | 4 | |
| GSE74703 | ARAP1 | 116985 | 7 | 2 | 27 | |
| GSE74704 | ARAP1 | 116985 | 6 | 4 | 10 | |
| TCGA | ARAP1 | 116985 | 35 | 21 | 40 |
Total number of gains: 112; Total number of losses: 97; Total Number of normals: 279.
Somatic mutations of ARAP1:
Generating mutation plots.
Highly correlated genes for ARAP1:
Showing top 20/125 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARAP1 | AP2M1 | 0.741935 | 3 | 0 | 3 |
| ARAP1 | FBXL19 | 0.737902 | 3 | 0 | 3 |
| ARAP1 | PPP1R10 | 0.716386 | 3 | 0 | 3 |
| ARAP1 | LSM5 | 0.714835 | 3 | 0 | 3 |
| ARAP1 | MORC2 | 0.714698 | 3 | 0 | 3 |
| ARAP1 | BAG6 | 0.710496 | 3 | 0 | 3 |
| ARAP1 | KIAA0556 | 0.709153 | 3 | 0 | 3 |
| ARAP1 | CPNE1 | 0.703267 | 3 | 0 | 3 |
| ARAP1 | LETM1 | 0.702857 | 3 | 0 | 3 |
| ARAP1 | STARD10 | 0.702245 | 8 | 0 | 7 |
| ARAP1 | MRPS34 | 0.701594 | 3 | 0 | 3 |
| ARAP1 | HGS | 0.699972 | 3 | 0 | 3 |
| ARAP1 | TBX20 | 0.694826 | 3 | 0 | 3 |
| ARAP1 | PRDX2 | 0.693035 | 3 | 0 | 3 |
| ARAP1 | SLC25A13 | 0.679568 | 3 | 0 | 3 |
| ARAP1 | TBRG4 | 0.679536 | 3 | 0 | 3 |
| ARAP1 | RFWD3 | 0.678848 | 3 | 0 | 3 |
| ARAP1 | VPS4A | 0.677035 | 3 | 0 | 3 |
| ARAP1 | CENPBD1 | 0.671499 | 4 | 0 | 3 |
| ARAP1 | PSMD3 | 0.668054 | 3 | 0 | 3 |
For details and further investigation, click here
