EXOSC6

 

Full name: exosome component 6 Alias Symbol: MTR3|hMtr3p|Mtr3p|EAP4|p11
Type: protein-coding gene Cytoband: 16q22.1
Entrez ID: 118460 HGNC ID: HGNC:19055 Ensembl Gene: ENSG00000223496 OMIM ID: 606490
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of EXOSC6:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 EXOSC6 118460 227696_at 0.1653 0.6509
GSE26886 EXOSC6 118460 227696_at -0.0032 0.9891
GSE45670 EXOSC6 118460 227696_at 0.1074 0.5279
GSE53622 EXOSC6 118460 26461 0.2993 0.0000
GSE53624 EXOSC6 118460 26461 0.1239 0.0197
GSE63941 EXOSC6 118460 227696_at -1.0342 0.1607
GSE77861 EXOSC6 118460 227696_at 0.4272 0.0733
GSE97050 EXOSC6 118460 A_24_P39639 0.1028 0.6305
SRP007169 EXOSC6 118460 RNAseq -0.0080 0.9830
SRP008496 EXOSC6 118460 RNAseq 0.2935 0.2767
SRP064894 EXOSC6 118460 RNAseq 0.2943 0.0431
SRP133303 EXOSC6 118460 RNAseq 0.3149 0.0227
SRP159526 EXOSC6 118460 RNAseq 0.8673 0.0270
SRP193095 EXOSC6 118460 RNAseq 0.3185 0.0045
SRP219564 EXOSC6 118460 RNAseq 0.0846 0.7334
TCGA EXOSC6 118460 RNAseq 0.1175 0.0561

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by EXOSC6 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of EXOSC6:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 EXOSC6 118460 6 1 23
GSE20123 EXOSC6 118460 6 1 23
GSE43470 EXOSC6 118460 2 8 33
GSE46452 EXOSC6 118460 38 1 20
GSE47630 EXOSC6 118460 11 8 21
GSE54993 EXOSC6 118460 2 4 64
GSE54994 EXOSC6 118460 8 10 35
GSE60625 EXOSC6 118460 4 0 7
GSE74703 EXOSC6 118460 2 5 29
GSE74704 EXOSC6 118460 3 0 17
TCGA EXOSC6 118460 27 12 57

Total number of gains: 109; Total number of losses: 50; Total Number of normals: 329.  

 

Somatic mutations of EXOSC6:

 

Generating mutation plots.

 

Highly correlated genes for EXOSC6:

 

Showing top 20/158 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
EXOSC6FAM169A0.778249303
EXOSC6MB21D20.774738303
EXOSC6NIPA10.7632303
EXOSC6TRADD0.756465303
EXOSC6ASAP20.754907303
EXOSC6POPDC30.735554303
EXOSC6RAB11FIP30.734824303
EXOSC6ABCB60.732237303
EXOSC6CBX10.731072404
EXOSC6KIDINS2200.730686303
EXOSC6GNB50.728891303
EXOSC6BMP20.721098303
EXOSC6PLEKHG10.71732303
EXOSC6WIZ0.713003303
EXOSC6CCDC85B0.711385303
EXOSC6PARVB0.708934303
EXOSC6KDELR30.70253303
EXOSC6SPIRE10.700177303
EXOSC6GLIS20.696887303
EXOSC6CEBPB0.696874404

For details and further investigation, click here