| Full name: tubulin tyrosine ligase like 4 | Alias Symbol: KIAA0173 | ||
| Type: protein-coding gene | Cytoband: 2q35 | ||
| Entrez ID: 9654 | HGNC ID: HGNC:28976 | Ensembl Gene: ENSG00000135912 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of TTLL4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TTLL4 | 9654 | 203702_s_at | 0.3296 | 0.1553 | |
| GSE20347 | TTLL4 | 9654 | 203702_s_at | 0.1954 | 0.3153 | |
| GSE23400 | TTLL4 | 9654 | 203702_s_at | 0.1772 | 0.0003 | |
| GSE26886 | TTLL4 | 9654 | 203702_s_at | -0.3030 | 0.1051 | |
| GSE29001 | TTLL4 | 9654 | 203703_s_at | 0.1309 | 0.4001 | |
| GSE38129 | TTLL4 | 9654 | 203702_s_at | 0.3147 | 0.0512 | |
| GSE45670 | TTLL4 | 9654 | 203702_s_at | 0.1605 | 0.1528 | |
| GSE53622 | TTLL4 | 9654 | 105891 | 0.2286 | 0.0505 | |
| GSE53624 | TTLL4 | 9654 | 105891 | 0.4850 | 0.0000 | |
| GSE63941 | TTLL4 | 9654 | 203702_s_at | 0.8455 | 0.0429 | |
| GSE77861 | TTLL4 | 9654 | 1557611_at | -0.1767 | 0.0690 | |
| GSE97050 | TTLL4 | 9654 | A_33_P3263387 | 0.2572 | 0.2610 | |
| SRP007169 | TTLL4 | 9654 | RNAseq | 0.7709 | 0.1163 | |
| SRP008496 | TTLL4 | 9654 | RNAseq | 0.9035 | 0.0070 | |
| SRP064894 | TTLL4 | 9654 | RNAseq | 0.3872 | 0.0067 | |
| SRP133303 | TTLL4 | 9654 | RNAseq | 0.3886 | 0.0035 | |
| SRP193095 | TTLL4 | 9654 | RNAseq | 0.1528 | 0.1977 | |
| SRP219564 | TTLL4 | 9654 | RNAseq | 0.3112 | 0.3575 | |
| TCGA | TTLL4 | 9654 | RNAseq | 0.0771 | 0.2789 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TTLL4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TTLL4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TTLL4 | 9654 | 1 | 14 | 15 | |
| GSE20123 | TTLL4 | 9654 | 1 | 13 | 16 | |
| GSE43470 | TTLL4 | 9654 | 1 | 7 | 35 | |
| GSE46452 | TTLL4 | 9654 | 0 | 5 | 54 | |
| GSE47630 | TTLL4 | 9654 | 4 | 5 | 31 | |
| GSE54993 | TTLL4 | 9654 | 1 | 2 | 67 | |
| GSE54994 | TTLL4 | 9654 | 8 | 10 | 35 | |
| GSE60625 | TTLL4 | 9654 | 0 | 3 | 8 | |
| GSE74703 | TTLL4 | 9654 | 1 | 5 | 30 | |
| GSE74704 | TTLL4 | 9654 | 1 | 7 | 12 | |
| TCGA | TTLL4 | 9654 | 11 | 27 | 58 |
Total number of gains: 29; Total number of losses: 98; Total Number of normals: 361.
Somatic mutations of TTLL4:
Generating mutation plots.
Highly correlated genes for TTLL4:
Showing top 20/296 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TTLL4 | MCMBP | 0.78791 | 3 | 0 | 3 |
| TTLL4 | SLC25A19 | 0.78643 | 3 | 0 | 3 |
| TTLL4 | LDLRAP1 | 0.774178 | 3 | 0 | 3 |
| TTLL4 | RPN1 | 0.762573 | 3 | 0 | 3 |
| TTLL4 | NSUN3 | 0.759401 | 3 | 0 | 3 |
| TTLL4 | LRRC8B | 0.756799 | 3 | 0 | 3 |
| TTLL4 | MRPL14 | 0.737106 | 3 | 0 | 3 |
| TTLL4 | SCOC | 0.735048 | 3 | 0 | 3 |
| TTLL4 | PRPS2 | 0.729026 | 3 | 0 | 3 |
| TTLL4 | SLC25A39 | 0.726901 | 4 | 0 | 4 |
| TTLL4 | PPP1R3D | 0.725935 | 3 | 0 | 3 |
| TTLL4 | RLIM | 0.719974 | 3 | 0 | 3 |
| TTLL4 | IFT80 | 0.712102 | 3 | 0 | 3 |
| TTLL4 | GAL | 0.701677 | 3 | 0 | 3 |
| TTLL4 | TP53RK | 0.696052 | 5 | 0 | 4 |
| TTLL4 | TMCO6 | 0.693532 | 3 | 0 | 3 |
| TTLL4 | CHD7 | 0.69109 | 3 | 0 | 3 |
| TTLL4 | VPS25 | 0.686706 | 3 | 0 | 3 |
| TTLL4 | IST1 | 0.686108 | 3 | 0 | 3 |
| TTLL4 | XPNPEP1 | 0.684548 | 4 | 0 | 3 |
For details and further investigation, click here
