| Full name: ribosome biogenesis regulator 1 homolog | Alias Symbol: KIAA0112 | ||
| Type: protein-coding gene | Cytoband: 8q13.1 | ||
| Entrez ID: 23212 | HGNC ID: HGNC:17083 | Ensembl Gene: ENSG00000179041 | OMIM ID: 618311 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of RRS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RRS1 | 23212 | 209567_at | 1.1874 | 0.0858 | |
| GSE20347 | RRS1 | 23212 | 209567_at | 0.8512 | 0.0000 | |
| GSE23400 | RRS1 | 23212 | 209567_at | 0.6205 | 0.0000 | |
| GSE26886 | RRS1 | 23212 | 209567_at | 0.4526 | 0.0282 | |
| GSE29001 | RRS1 | 23212 | 209567_at | 0.7961 | 0.0036 | |
| GSE38129 | RRS1 | 23212 | 209567_at | 0.7845 | 0.0000 | |
| GSE45670 | RRS1 | 23212 | 209567_at | 0.7068 | 0.0001 | |
| GSE53622 | RRS1 | 23212 | 105128 | 0.6070 | 0.0000 | |
| GSE53624 | RRS1 | 23212 | 105128 | 0.8680 | 0.0000 | |
| GSE63941 | RRS1 | 23212 | 209567_at | -0.0410 | 0.9595 | |
| GSE77861 | RRS1 | 23212 | 209567_at | 0.6804 | 0.0219 | |
| GSE97050 | RRS1 | 23212 | A_23_P146187 | 0.4077 | 0.2525 | |
| SRP007169 | RRS1 | 23212 | RNAseq | 0.7724 | 0.0532 | |
| SRP008496 | RRS1 | 23212 | RNAseq | 0.8876 | 0.0017 | |
| SRP064894 | RRS1 | 23212 | RNAseq | 0.7751 | 0.0027 | |
| SRP133303 | RRS1 | 23212 | RNAseq | 0.8209 | 0.0001 | |
| SRP159526 | RRS1 | 23212 | RNAseq | 0.6677 | 0.0494 | |
| SRP193095 | RRS1 | 23212 | RNAseq | 0.6195 | 0.0000 | |
| SRP219564 | RRS1 | 23212 | RNAseq | 1.1576 | 0.0467 | |
| TCGA | RRS1 | 23212 | RNAseq | 0.1802 | 0.0050 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by RRS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RRS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RRS1 | 23212 | 14 | 1 | 15 | |
| GSE20123 | RRS1 | 23212 | 15 | 1 | 14 | |
| GSE43470 | RRS1 | 23212 | 15 | 3 | 25 | |
| GSE46452 | RRS1 | 23212 | 20 | 2 | 37 | |
| GSE47630 | RRS1 | 23212 | 23 | 1 | 16 | |
| GSE54993 | RRS1 | 23212 | 1 | 18 | 51 | |
| GSE54994 | RRS1 | 23212 | 30 | 0 | 23 | |
| GSE60625 | RRS1 | 23212 | 0 | 4 | 7 | |
| GSE74703 | RRS1 | 23212 | 13 | 2 | 21 | |
| GSE74704 | RRS1 | 23212 | 10 | 0 | 10 | |
| TCGA | RRS1 | 23212 | 49 | 5 | 42 |
Total number of gains: 190; Total number of losses: 37; Total Number of normals: 261.
Somatic mutations of RRS1:
Generating mutation plots.
Highly correlated genes for RRS1:
Showing top 20/1769 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RRS1 | ZNF584 | 0.801738 | 3 | 0 | 3 |
| RRS1 | SLC39A3 | 0.799794 | 3 | 0 | 3 |
| RRS1 | TP53RK | 0.784727 | 3 | 0 | 3 |
| RRS1 | ZNF707 | 0.773107 | 3 | 0 | 3 |
| RRS1 | TGS1 | 0.772771 | 10 | 0 | 10 |
| RRS1 | PKP4 | 0.759418 | 3 | 0 | 3 |
| RRS1 | PUF60 | 0.757655 | 11 | 0 | 11 |
| RRS1 | DHX37 | 0.752282 | 5 | 0 | 5 |
| RRS1 | DDX55 | 0.747951 | 7 | 0 | 7 |
| RRS1 | RNASEH2B | 0.743677 | 3 | 0 | 3 |
| RRS1 | MIEN1 | 0.743318 | 3 | 0 | 3 |
| RRS1 | EXOSC10 | 0.736324 | 3 | 0 | 3 |
| RRS1 | MTFR2 | 0.736229 | 4 | 0 | 4 |
| RRS1 | ZNF408 | 0.73323 | 3 | 0 | 3 |
| RRS1 | UBE2C | 0.728291 | 11 | 0 | 11 |
| RRS1 | MTERF3 | 0.721393 | 9 | 0 | 7 |
| RRS1 | ZBED6 | 0.721389 | 3 | 0 | 3 |
| RRS1 | TMEM63B | 0.71368 | 4 | 0 | 3 |
| RRS1 | MTBP | 0.713356 | 6 | 0 | 5 |
| RRS1 | POLR1A | 0.711299 | 3 | 0 | 3 |
For details and further investigation, click here
