| Full name: lengsin, lens protein with glutamine synthetase domain | Alias Symbol: LGS | ||
| Type: protein-coding gene | Cytoband: 6q12 | ||
| Entrez ID: 51557 | HGNC ID: HGNC:21016 | Ensembl Gene: ENSG00000146166 | OMIM ID: 611470 |
| Drug and gene relationship at DGIdb | |||
Expression of LGSN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LGSN | 51557 | 220393_at | 0.1167 | 0.5839 | |
| GSE20347 | LGSN | 51557 | 220393_at | 0.1791 | 0.0099 | |
| GSE23400 | LGSN | 51557 | 220393_at | -0.0054 | 0.7456 | |
| GSE26886 | LGSN | 51557 | 220393_at | 0.1364 | 0.1783 | |
| GSE29001 | LGSN | 51557 | 220393_at | 0.2675 | 0.3241 | |
| GSE38129 | LGSN | 51557 | 220393_at | 0.2390 | 0.0440 | |
| GSE45670 | LGSN | 51557 | 220393_at | 0.4170 | 0.3659 | |
| GSE53622 | LGSN | 51557 | 19707 | 0.3632 | 0.1154 | |
| GSE53624 | LGSN | 51557 | 19707 | 0.7166 | 0.0000 | |
| GSE63941 | LGSN | 51557 | 220393_at | -0.2193 | 0.9016 | |
| GSE77861 | LGSN | 51557 | 220393_at | 0.0296 | 0.7485 | |
| SRP133303 | LGSN | 51557 | RNAseq | 0.1396 | 0.4539 | |
| SRP193095 | LGSN | 51557 | RNAseq | 0.4951 | 0.0155 | |
| TCGA | LGSN | 51557 | RNAseq | -1.2333 | 0.1846 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LGSN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LGSN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LGSN | 51557 | 1 | 4 | 25 | |
| GSE20123 | LGSN | 51557 | 1 | 4 | 25 | |
| GSE43470 | LGSN | 51557 | 6 | 0 | 37 | |
| GSE46452 | LGSN | 51557 | 3 | 10 | 46 | |
| GSE47630 | LGSN | 51557 | 8 | 4 | 28 | |
| GSE54993 | LGSN | 51557 | 3 | 2 | 65 | |
| GSE54994 | LGSN | 51557 | 11 | 2 | 40 | |
| GSE60625 | LGSN | 51557 | 0 | 2 | 9 | |
| GSE74703 | LGSN | 51557 | 6 | 0 | 30 | |
| GSE74704 | LGSN | 51557 | 0 | 3 | 17 | |
| TCGA | LGSN | 51557 | 20 | 11 | 65 |
Total number of gains: 59; Total number of losses: 42; Total Number of normals: 387.
Somatic mutations of LGSN:
Generating mutation plots.
Highly correlated genes for LGSN:
Showing top 20/26 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LGSN | PCSK1 | 0.725084 | 5 | 0 | 5 |
| LGSN | BARX1 | 0.63986 | 3 | 0 | 3 |
| LGSN | FAM167B | 0.623458 | 3 | 0 | 3 |
| LGSN | TRO | 0.61269 | 3 | 0 | 3 |
| LGSN | COL9A3 | 0.606652 | 4 | 0 | 3 |
| LGSN | GLS | 0.590964 | 3 | 0 | 3 |
| LGSN | CDKAL1 | 0.584117 | 5 | 0 | 3 |
| LGSN | NES | 0.578931 | 4 | 0 | 3 |
| LGSN | TMPRSS3 | 0.574895 | 7 | 0 | 4 |
| LGSN | PPP1R1C | 0.572991 | 4 | 0 | 3 |
| LGSN | OGDHL | 0.566899 | 6 | 0 | 4 |
| LGSN | ZFP69B | 0.562462 | 4 | 0 | 3 |
| LGSN | INHBE | 0.559896 | 5 | 0 | 3 |
| LGSN | ADAM8 | 0.554908 | 4 | 0 | 3 |
| LGSN | RAB11FIP3 | 0.554908 | 5 | 0 | 4 |
| LGSN | TRPC4 | 0.552798 | 5 | 0 | 3 |
| LGSN | PLA2G7 | 0.551498 | 5 | 0 | 3 |
| LGSN | FGF9 | 0.542203 | 3 | 0 | 3 |
| LGSN | SSX3 | 0.541511 | 4 | 0 | 3 |
| LGSN | PAX6 | 0.537043 | 4 | 0 | 3 |
For details and further investigation, click here
