| Full name: transmembrane serine protease 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 21q22.3 | ||
| Entrez ID: 64699 | HGNC ID: HGNC:11877 | Ensembl Gene: ENSG00000160183 | OMIM ID: 605511 |
| Drug and gene relationship at DGIdb | |||
Expression of TMPRSS3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMPRSS3 | 64699 | 223948_s_at | 0.2271 | 0.4026 | |
| GSE20347 | TMPRSS3 | 64699 | 220177_s_at | 0.1233 | 0.6968 | |
| GSE23400 | TMPRSS3 | 64699 | 220177_s_at | -0.0865 | 0.0074 | |
| GSE26886 | TMPRSS3 | 64699 | 223948_s_at | 0.1577 | 0.0662 | |
| GSE29001 | TMPRSS3 | 64699 | 220177_s_at | 0.3348 | 0.2381 | |
| GSE38129 | TMPRSS3 | 64699 | 220177_s_at | 0.0309 | 0.9356 | |
| GSE45670 | TMPRSS3 | 64699 | 223948_s_at | 0.0852 | 0.5149 | |
| GSE53622 | TMPRSS3 | 64699 | 4531 | -0.1364 | 0.6438 | |
| GSE53624 | TMPRSS3 | 64699 | 123888 | -0.2929 | 0.2588 | |
| GSE63941 | TMPRSS3 | 64699 | 223948_s_at | 0.7585 | 0.1442 | |
| GSE77861 | TMPRSS3 | 64699 | 223948_s_at | 0.0710 | 0.6147 | |
| GSE97050 | TMPRSS3 | 64699 | A_23_P80162 | 0.1247 | 0.5722 | |
| SRP133303 | TMPRSS3 | 64699 | RNAseq | -0.5172 | 0.1146 | |
| SRP219564 | TMPRSS3 | 64699 | RNAseq | 2.3947 | 0.0095 | |
| TCGA | TMPRSS3 | 64699 | RNAseq | -1.1830 | 0.0216 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by TMPRSS3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMPRSS3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMPRSS3 | 64699 | 2 | 8 | 20 | |
| GSE20123 | TMPRSS3 | 64699 | 2 | 8 | 20 | |
| GSE43470 | TMPRSS3 | 64699 | 0 | 13 | 30 | |
| GSE46452 | TMPRSS3 | 64699 | 1 | 21 | 37 | |
| GSE47630 | TMPRSS3 | 64699 | 6 | 17 | 17 | |
| GSE54993 | TMPRSS3 | 64699 | 8 | 1 | 61 | |
| GSE54994 | TMPRSS3 | 64699 | 4 | 8 | 41 | |
| GSE60625 | TMPRSS3 | 64699 | 0 | 0 | 11 | |
| GSE74703 | TMPRSS3 | 64699 | 0 | 10 | 26 | |
| GSE74704 | TMPRSS3 | 64699 | 1 | 4 | 15 | |
| TCGA | TMPRSS3 | 64699 | 7 | 41 | 48 |
Total number of gains: 31; Total number of losses: 131; Total Number of normals: 326.
Somatic mutations of TMPRSS3:
Generating mutation plots.
Highly correlated genes for TMPRSS3:
Showing top 20/211 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMPRSS3 | SOX18 | 0.763777 | 3 | 0 | 3 |
| TMPRSS3 | SND1 | 0.680558 | 3 | 0 | 3 |
| TMPRSS3 | SLC25A1 | 0.674568 | 3 | 0 | 3 |
| TMPRSS3 | TCF20 | 0.659814 | 3 | 0 | 3 |
| TMPRSS3 | SNAPC2 | 0.659499 | 4 | 0 | 3 |
| TMPRSS3 | TRPM7 | 0.658861 | 3 | 0 | 3 |
| TMPRSS3 | FAM167B | 0.652649 | 4 | 0 | 3 |
| TMPRSS3 | GGT5 | 0.652544 | 4 | 0 | 4 |
| TMPRSS3 | ZNF594 | 0.65144 | 3 | 0 | 3 |
| TMPRSS3 | GLI1 | 0.648279 | 3 | 0 | 3 |
| TMPRSS3 | ITGB2 | 0.64748 | 4 | 0 | 3 |
| TMPRSS3 | PI16 | 0.646923 | 3 | 0 | 3 |
| TMPRSS3 | PCGF2 | 0.64303 | 4 | 0 | 4 |
| TMPRSS3 | ICAM1 | 0.641653 | 5 | 0 | 5 |
| TMPRSS3 | APEX2 | 0.641531 | 3 | 0 | 3 |
| TMPRSS3 | RPAP2 | 0.638435 | 3 | 0 | 3 |
| TMPRSS3 | DDX39A | 0.633003 | 3 | 0 | 3 |
| TMPRSS3 | INTS3 | 0.631182 | 3 | 0 | 3 |
| TMPRSS3 | GAA | 0.630032 | 4 | 0 | 3 |
| TMPRSS3 | RPTOR | 0.629854 | 3 | 0 | 3 |
For details and further investigation, click here
