ADAM8

 

Full name: ADAM metallopeptidase domain 8 Alias Symbol: CD156|MS2|CD156A
Type: protein-coding gene Cytoband: 10q26.3
Entrez ID: 101 HGNC ID: HGNC:215 Ensembl Gene: ENSG00000151651 OMIM ID: 602267
Drug and gene relationship at DGIdb

 

Expression of ADAM8:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ADAM8 101 205180_s_at 1.2457 0.0552
GSE20347 ADAM8 101 205180_s_at 0.4127 0.0065
GSE23400 ADAM8 101 205180_s_at 0.3081 0.0001
GSE26886 ADAM8 101 205180_s_at 0.7455 0.0114
GSE29001 ADAM8 101 205180_s_at 0.7390 0.0091
GSE38129 ADAM8 101 205180_s_at 0.4489 0.0010
GSE45670 ADAM8 101 205180_s_at 0.4828 0.0203
GSE53622 ADAM8 101 20208 0.4083 0.0000
GSE53624 ADAM8 101 20208 0.2217 0.0200
GSE63941 ADAM8 101 205180_s_at 0.4035 0.3587
GSE77861 ADAM8 101 205180_s_at 0.0780 0.6585
GSE97050 ADAM8 101 A_24_P300777 0.8643 0.1552
SRP007169 ADAM8 101 RNAseq 1.6452 0.0052
SRP008496 ADAM8 101 RNAseq 0.8462 0.0381
SRP064894 ADAM8 101 RNAseq 1.0468 0.0010
SRP133303 ADAM8 101 RNAseq 1.0776 0.0001
SRP159526 ADAM8 101 RNAseq -0.1839 0.7383
SRP193095 ADAM8 101 RNAseq 1.7927 0.0000
SRP219564 ADAM8 101 RNAseq 1.3840 0.0153
TCGA ADAM8 101 RNAseq 0.5066 0.0017

Upregulated datasets: 5; Downregulated datasets: 0.  

 

Survival by ADAM8 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ADAM8:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ADAM8 101 3 8 19
GSE20123 ADAM8 101 3 9 18
GSE43470 ADAM8 101 0 9 34
GSE46452 ADAM8 101 1 11 47
GSE47630 ADAM8 101 4 13 23
GSE54993 ADAM8 101 8 2 60
GSE54994 ADAM8 101 1 9 43
GSE60625 ADAM8 101 0 0 11
GSE74703 ADAM8 101 0 6 30
GSE74704 ADAM8 101 3 4 13
TCGA ADAM8 101 7 28 61

Total number of gains: 30; Total number of losses: 99; Total Number of normals: 359.  

 

Somatic mutations of ADAM8:

 

Generating mutation plots.

 

Highly correlated genes for ADAM8:

 

Showing top 20/700 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ADAM8PNPT10.741981303
ADAM8TRAPPC3L0.730701303
ADAM8LINC011010.726798303
ADAM8TRIM460.718547403
ADAM8PNPLA30.710888303
ADAM8SLC7A50.698379303
ADAM8GPR680.692792605
ADAM8OR4F150.690555303
ADAM8CYP27B10.688524909
ADAM8RBM430.684311303
ADAM8CXCL50.683772605
ADAM8FOXE30.683179303
ADAM8ELOVL30.676447404
ADAM8CCM20.670063504
ADAM8SHISA70.669812303
ADAM8CA60.669004303
ADAM8TNRC6C-AS10.668222303
ADAM8TMSB100.667959806
ADAM8CXCL110.665794707
ADAM8P2RY60.663988403

For details and further investigation, click here