| Full name: protein phosphatase 1 regulatory inhibitor subunit 1C | Alias Symbol: Inhibitor-1-like | ||
| Type: protein-coding gene | Cytoband: 2q31.3-q32.1 | ||
| Entrez ID: 151242 | HGNC ID: HGNC:14940 | Ensembl Gene: ENSG00000150722 | OMIM ID: 613240 |
| Drug and gene relationship at DGIdb | |||
Expression of PPP1R1C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP1R1C | 151242 | 228646_at | 0.1371 | 0.7195 | |
| GSE26886 | PPP1R1C | 151242 | 228646_at | 0.6391 | 0.0026 | |
| GSE45670 | PPP1R1C | 151242 | 228646_at | 0.4512 | 0.0063 | |
| GSE53622 | PPP1R1C | 151242 | 24705 | 0.8846 | 0.0000 | |
| GSE53624 | PPP1R1C | 151242 | 24705 | 1.3064 | 0.0000 | |
| GSE63941 | PPP1R1C | 151242 | 228646_at | 0.4616 | 0.5489 | |
| GSE77861 | PPP1R1C | 151242 | 228646_at | 0.2572 | 0.0665 | |
| GSE97050 | PPP1R1C | 151242 | A_32_P66364 | 0.1968 | 0.7151 | |
| TCGA | PPP1R1C | 151242 | RNAseq | 0.4417 | 0.1540 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PPP1R1C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP1R1C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP1R1C | 151242 | 5 | 1 | 24 | |
| GSE20123 | PPP1R1C | 151242 | 5 | 1 | 24 | |
| GSE43470 | PPP1R1C | 151242 | 5 | 1 | 37 | |
| GSE46452 | PPP1R1C | 151242 | 1 | 4 | 54 | |
| GSE47630 | PPP1R1C | 151242 | 4 | 4 | 32 | |
| GSE54993 | PPP1R1C | 151242 | 0 | 5 | 65 | |
| GSE54994 | PPP1R1C | 151242 | 12 | 5 | 36 | |
| GSE60625 | PPP1R1C | 151242 | 0 | 3 | 8 | |
| GSE74703 | PPP1R1C | 151242 | 4 | 1 | 31 | |
| GSE74704 | PPP1R1C | 151242 | 2 | 1 | 17 | |
| TCGA | PPP1R1C | 151242 | 25 | 9 | 62 |
Total number of gains: 63; Total number of losses: 35; Total Number of normals: 390.
Somatic mutations of PPP1R1C:
Generating mutation plots.
Highly correlated genes for PPP1R1C:
Showing top 20/97 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP1R1C | PROX1 | 0.728332 | 3 | 0 | 3 |
| PPP1R1C | OSBPL6 | 0.657559 | 3 | 0 | 3 |
| PPP1R1C | LINC00260 | 0.651952 | 3 | 0 | 3 |
| PPP1R1C | ALOX15 | 0.639369 | 3 | 0 | 3 |
| PPP1R1C | CCDC86 | 0.632868 | 3 | 0 | 3 |
| PPP1R1C | LAMB1 | 0.619202 | 4 | 0 | 3 |
| PPP1R1C | MET | 0.606814 | 5 | 0 | 4 |
| PPP1R1C | COL9A3 | 0.606217 | 4 | 0 | 3 |
| PPP1R1C | TUT1 | 0.606111 | 3 | 0 | 3 |
| PPP1R1C | GNB5 | 0.599174 | 4 | 0 | 3 |
| PPP1R1C | KCNC4 | 0.597556 | 3 | 0 | 3 |
| PPP1R1C | MYC | 0.589291 | 3 | 0 | 3 |
| PPP1R1C | C11orf24 | 0.584627 | 5 | 0 | 3 |
| PPP1R1C | PDGFA | 0.583227 | 4 | 0 | 3 |
| PPP1R1C | IL24 | 0.581593 | 3 | 0 | 3 |
| PPP1R1C | DNAH11 | 0.578584 | 4 | 0 | 3 |
| PPP1R1C | SOCS1 | 0.577884 | 4 | 0 | 3 |
| PPP1R1C | LGSN | 0.572991 | 4 | 0 | 3 |
| PPP1R1C | ADAMTSL2 | 0.57234 | 3 | 0 | 3 |
| PPP1R1C | ORC3 | 0.571113 | 4 | 0 | 3 |
For details and further investigation, click here
