| Full name: proprotein convertase subtilisin/kexin type 1 | Alias Symbol: PC1|PC3|SPC3 | ||
| Type: protein-coding gene | Cytoband: 5q15 | ||
| Entrez ID: 5122 | HGNC ID: HGNC:8743 | Ensembl Gene: ENSG00000175426 | OMIM ID: 162150 |
| Drug and gene relationship at DGIdb | |||
Expression of PCSK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PCSK1 | 5122 | 205825_at | 0.5751 | 0.3660 | |
| GSE20347 | PCSK1 | 5122 | 205825_at | 0.2278 | 0.1271 | |
| GSE23400 | PCSK1 | 5122 | 205825_at | -0.0051 | 0.8631 | |
| GSE26886 | PCSK1 | 5122 | 205825_at | 0.2114 | 0.1142 | |
| GSE29001 | PCSK1 | 5122 | 205825_at | 0.3318 | 0.1751 | |
| GSE38129 | PCSK1 | 5122 | 205825_at | 0.2352 | 0.4412 | |
| GSE45670 | PCSK1 | 5122 | 205825_at | 0.7859 | 0.1150 | |
| GSE53622 | PCSK1 | 5122 | 147378 | 0.0540 | 0.7818 | |
| GSE53624 | PCSK1 | 5122 | 147378 | 0.5148 | 0.0022 | |
| GSE63941 | PCSK1 | 5122 | 205825_at | -1.6654 | 0.2244 | |
| GSE77861 | PCSK1 | 5122 | 205825_at | 0.0819 | 0.2765 | |
| GSE97050 | PCSK1 | 5122 | A_24_P174793 | -0.0034 | 0.9925 | |
| SRP133303 | PCSK1 | 5122 | RNAseq | -0.7643 | 0.0385 | |
| SRP159526 | PCSK1 | 5122 | RNAseq | 1.5573 | 0.0603 | |
| SRP193095 | PCSK1 | 5122 | RNAseq | -0.1991 | 0.3956 | |
| SRP219564 | PCSK1 | 5122 | RNAseq | 2.8370 | 0.0000 | |
| TCGA | PCSK1 | 5122 | RNAseq | -0.5757 | 0.0467 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PCSK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PCSK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PCSK1 | 5122 | 1 | 13 | 16 | |
| GSE20123 | PCSK1 | 5122 | 1 | 13 | 16 | |
| GSE43470 | PCSK1 | 5122 | 3 | 9 | 31 | |
| GSE46452 | PCSK1 | 5122 | 0 | 28 | 31 | |
| GSE47630 | PCSK1 | 5122 | 0 | 20 | 20 | |
| GSE54993 | PCSK1 | 5122 | 8 | 1 | 61 | |
| GSE54994 | PCSK1 | 5122 | 1 | 18 | 34 | |
| GSE60625 | PCSK1 | 5122 | 0 | 0 | 11 | |
| GSE74703 | PCSK1 | 5122 | 2 | 7 | 27 | |
| GSE74704 | PCSK1 | 5122 | 1 | 7 | 12 | |
| TCGA | PCSK1 | 5122 | 3 | 43 | 50 |
Total number of gains: 20; Total number of losses: 159; Total Number of normals: 309.
Somatic mutations of PCSK1:
Generating mutation plots.
Highly correlated genes for PCSK1:
Showing top 20/277 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PCSK1 | SMOX | 0.767796 | 3 | 0 | 3 |
| PCSK1 | STEAP1B | 0.733663 | 3 | 0 | 3 |
| PCSK1 | TNFRSF10D | 0.725646 | 3 | 0 | 3 |
| PCSK1 | LGSN | 0.725084 | 5 | 0 | 5 |
| PCSK1 | SEC61G | 0.724125 | 3 | 0 | 3 |
| PCSK1 | FAP | 0.719606 | 3 | 0 | 3 |
| PCSK1 | ZCCHC3 | 0.719361 | 3 | 0 | 3 |
| PCSK1 | TBX1 | 0.714189 | 3 | 0 | 3 |
| PCSK1 | SLC6A15 | 0.701689 | 3 | 0 | 3 |
| PCSK1 | USP45 | 0.697331 | 3 | 0 | 3 |
| PCSK1 | NEK6 | 0.696472 | 3 | 0 | 3 |
| PCSK1 | RPA3 | 0.679106 | 4 | 0 | 4 |
| PCSK1 | ZNF764 | 0.676172 | 3 | 0 | 3 |
| PCSK1 | UBE3C | 0.675056 | 3 | 0 | 3 |
| PCSK1 | CHCHD2 | 0.67503 | 3 | 0 | 3 |
| PCSK1 | FARSA | 0.66864 | 3 | 0 | 3 |
| PCSK1 | HAUS6 | 0.668103 | 3 | 0 | 3 |
| PCSK1 | KREMEN1 | 0.667495 | 3 | 0 | 3 |
| PCSK1 | STC2 | 0.666091 | 4 | 0 | 3 |
| PCSK1 | MAP3K11 | 0.661926 | 3 | 0 | 3 |
For details and further investigation, click here
