| Full name: transient receptor potential cation channel subfamily C member 4 | Alias Symbol: HTRP4|TRP4 | ||
| Type: protein-coding gene | Cytoband: 13q13.3 | ||
| Entrez ID: 7223 | HGNC ID: HGNC:12336 | Ensembl Gene: ENSG00000133107 | OMIM ID: 603651 |
| Drug and gene relationship at DGIdb | |||
TRPC4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of TRPC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRPC4 | 7223 | 224220_x_at | 0.0558 | 0.8595 | |
| GSE20347 | TRPC4 | 7223 | 220818_s_at | -0.0022 | 0.9814 | |
| GSE23400 | TRPC4 | 7223 | 220818_s_at | -0.0575 | 0.0343 | |
| GSE26886 | TRPC4 | 7223 | 224220_x_at | 0.2052 | 0.0723 | |
| GSE29001 | TRPC4 | 7223 | 220817_at | 0.0404 | 0.7869 | |
| GSE38129 | TRPC4 | 7223 | 220818_s_at | -0.0104 | 0.9212 | |
| GSE45670 | TRPC4 | 7223 | 224220_x_at | 0.0285 | 0.7372 | |
| GSE53622 | TRPC4 | 7223 | 44700 | 0.4237 | 0.0061 | |
| GSE53624 | TRPC4 | 7223 | 44700 | 1.0425 | 0.0000 | |
| GSE63941 | TRPC4 | 7223 | 224220_x_at | -0.0873 | 0.7570 | |
| GSE77861 | TRPC4 | 7223 | 220818_s_at | 0.0377 | 0.8127 | |
| GSE97050 | TRPC4 | 7223 | A_23_P105873 | -0.1091 | 0.6103 | |
| SRP133303 | TRPC4 | 7223 | RNAseq | 0.1440 | 0.5226 | |
| SRP159526 | TRPC4 | 7223 | RNAseq | 1.9019 | 0.0093 | |
| SRP219564 | TRPC4 | 7223 | RNAseq | 1.2604 | 0.0282 | |
| TCGA | TRPC4 | 7223 | RNAseq | 0.3452 | 0.2401 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by TRPC4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRPC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRPC4 | 7223 | 0 | 16 | 14 | |
| GSE20123 | TRPC4 | 7223 | 0 | 15 | 15 | |
| GSE43470 | TRPC4 | 7223 | 3 | 13 | 27 | |
| GSE46452 | TRPC4 | 7223 | 0 | 33 | 26 | |
| GSE47630 | TRPC4 | 7223 | 2 | 27 | 11 | |
| GSE54993 | TRPC4 | 7223 | 12 | 2 | 56 | |
| GSE54994 | TRPC4 | 7223 | 1 | 17 | 35 | |
| GSE60625 | TRPC4 | 7223 | 0 | 3 | 8 | |
| GSE74703 | TRPC4 | 7223 | 3 | 10 | 23 | |
| GSE74704 | TRPC4 | 7223 | 0 | 12 | 8 | |
| TCGA | TRPC4 | 7223 | 7 | 40 | 49 |
Total number of gains: 28; Total number of losses: 188; Total Number of normals: 272.
Somatic mutations of TRPC4:
Generating mutation plots.
Highly correlated genes for TRPC4:
Showing top 20/172 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRPC4 | FAM166A | 0.760971 | 3 | 0 | 3 |
| TRPC4 | C17orf99 | 0.703318 | 3 | 0 | 3 |
| TRPC4 | FAM167B | 0.67826 | 3 | 0 | 3 |
| TRPC4 | TCF20 | 0.677837 | 3 | 0 | 3 |
| TRPC4 | PTPRE | 0.676984 | 3 | 0 | 3 |
| TRPC4 | POU3F4 | 0.666014 | 4 | 0 | 3 |
| TRPC4 | TFR2 | 0.659979 | 4 | 0 | 4 |
| TRPC4 | GRWD1 | 0.657469 | 3 | 0 | 3 |
| TRPC4 | ZNF334 | 0.656908 | 3 | 0 | 3 |
| TRPC4 | SLC6A2 | 0.656043 | 3 | 0 | 3 |
| TRPC4 | SREBF2 | 0.654182 | 3 | 0 | 3 |
| TRPC4 | NAGLU | 0.6519 | 4 | 0 | 4 |
| TRPC4 | ZDHHC9 | 0.651163 | 3 | 0 | 3 |
| TRPC4 | TBC1D2 | 0.650616 | 3 | 0 | 3 |
| TRPC4 | TMEM132C | 0.650097 | 3 | 0 | 3 |
| TRPC4 | COX19 | 0.649187 | 4 | 0 | 3 |
| TRPC4 | ARSD | 0.648995 | 3 | 0 | 3 |
| TRPC4 | ZNF287 | 0.637317 | 3 | 0 | 3 |
| TRPC4 | RAD18 | 0.633828 | 3 | 0 | 3 |
| TRPC4 | ICAM5 | 0.633333 | 3 | 0 | 3 |
For details and further investigation, click here
