| Full name: LIM homeobox 4 | Alias Symbol: Gsh4 | ||
| Type: protein-coding gene | Cytoband: 1q25.2 | ||
| Entrez ID: 89884 | HGNC ID: HGNC:21734 | Ensembl Gene: ENSG00000121454 | OMIM ID: 602146 |
| Drug and gene relationship at DGIdb | |||
Expression of LHX4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LHX4 | 89884 | 1553156_at | -0.2183 | 0.3870 | |
| GSE26886 | LHX4 | 89884 | 1553156_at | 0.0508 | 0.6358 | |
| GSE45670 | LHX4 | 89884 | 1553156_at | -0.0070 | 0.9451 | |
| GSE53622 | LHX4 | 89884 | 59302 | -0.2654 | 0.1661 | |
| GSE53624 | LHX4 | 89884 | 59302 | -0.3919 | 0.0023 | |
| GSE63941 | LHX4 | 89884 | 1553156_at | 0.0263 | 0.8819 | |
| GSE77861 | LHX4 | 89884 | 1553156_at | -0.0190 | 0.9075 | |
| SRP064894 | LHX4 | 89884 | RNAseq | -0.4049 | 0.3203 | |
| SRP133303 | LHX4 | 89884 | RNAseq | 0.1149 | 0.6947 | |
| SRP159526 | LHX4 | 89884 | RNAseq | 0.1413 | 0.7260 | |
| SRP193095 | LHX4 | 89884 | RNAseq | 0.3548 | 0.0180 | |
| SRP219564 | LHX4 | 89884 | RNAseq | 0.1837 | 0.8044 | |
| TCGA | LHX4 | 89884 | RNAseq | 0.5953 | 0.0330 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LHX4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LHX4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LHX4 | 89884 | 12 | 0 | 18 | |
| GSE20123 | LHX4 | 89884 | 12 | 0 | 18 | |
| GSE43470 | LHX4 | 89884 | 6 | 1 | 36 | |
| GSE46452 | LHX4 | 89884 | 3 | 1 | 55 | |
| GSE47630 | LHX4 | 89884 | 14 | 0 | 26 | |
| GSE54993 | LHX4 | 89884 | 0 | 6 | 64 | |
| GSE54994 | LHX4 | 89884 | 15 | 0 | 38 | |
| GSE60625 | LHX4 | 89884 | 0 | 0 | 11 | |
| GSE74703 | LHX4 | 89884 | 6 | 1 | 29 | |
| GSE74704 | LHX4 | 89884 | 5 | 0 | 15 | |
| TCGA | LHX4 | 89884 | 40 | 3 | 53 |
Total number of gains: 113; Total number of losses: 12; Total Number of normals: 363.
Somatic mutations of LHX4:
Generating mutation plots.
Highly correlated genes for LHX4:
Showing top 20/22 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LHX4 | VENTX | 0.694613 | 3 | 0 | 3 |
| LHX4 | KCNE1 | 0.644436 | 3 | 0 | 3 |
| LHX4 | PKD2L1 | 0.621842 | 4 | 0 | 4 |
| LHX4 | GPHB5 | 0.597187 | 3 | 0 | 3 |
| LHX4 | CA5A | 0.597159 | 3 | 0 | 3 |
| LHX4 | IL1RL1 | 0.579952 | 3 | 0 | 3 |
| LHX4 | ROM1 | 0.566657 | 3 | 0 | 3 |
| LHX4 | KLHL17 | 0.566503 | 4 | 0 | 3 |
| LHX4 | LINC00851 | 0.558892 | 3 | 0 | 3 |
| LHX4 | PGLYRP1 | 0.550469 | 4 | 0 | 3 |
| LHX4 | CDH15 | 0.544922 | 3 | 0 | 3 |
| LHX4 | LRRC55 | 0.539446 | 3 | 0 | 3 |
| LHX4 | FSHB | 0.539443 | 4 | 0 | 3 |
| LHX4 | PLA2G5 | 0.537365 | 4 | 0 | 3 |
| LHX4 | FOXH1 | 0.535487 | 3 | 0 | 3 |
| LHX4 | HNF1A | 0.530297 | 4 | 0 | 3 |
| LHX4 | ARMC3 | 0.527062 | 4 | 0 | 3 |
| LHX4 | PRRG3 | 0.526079 | 3 | 0 | 3 |
| LHX4 | CTRB2 | 0.525125 | 5 | 0 | 4 |
| LHX4 | CABP2 | 0.517311 | 5 | 0 | 3 |
For details and further investigation, click here
