| Full name: leukocyte immunoglobulin like receptor B3 | Alias Symbol: LIR-3|HL9|ILT5|LIR3|CD85a|PIRB|PIR-B | ||
| Type: protein-coding gene | Cytoband: 19q13.42 | ||
| Entrez ID: 11025 | HGNC ID: HGNC:6607 | Ensembl Gene: ENSG00000204577 | OMIM ID: 604820 |
| Drug and gene relationship at DGIdb | |||
LILRB3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04380 | Osteoclast differentiation | |
| hsa04380 | Osteoclast differentiation | |
| hsa04662 | B cell receptor signaling pathway |
Expression of LILRB3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LILRB3 | 11025 | 210225_x_at | 0.0993 | 0.8109 | |
| GSE20347 | LILRB3 | 11025 | 211135_x_at | 0.0138 | 0.8922 | |
| GSE23400 | LILRB3 | 11025 | 210784_x_at | 0.0331 | 0.4788 | |
| GSE26886 | LILRB3 | 11025 | 211135_x_at | -0.1075 | 0.4787 | |
| GSE29001 | LILRB3 | 11025 | 211135_x_at | -0.1667 | 0.2340 | |
| GSE38129 | LILRB3 | 11025 | 210784_x_at | -0.0548 | 0.6742 | |
| GSE45670 | LILRB3 | 11025 | 210225_x_at | -0.0122 | 0.9400 | |
| GSE63941 | LILRB3 | 11025 | 211133_x_at | 0.4243 | 0.0103 | |
| GSE77861 | LILRB3 | 11025 | 210784_x_at | 0.1269 | 0.3105 | |
| GSE97050 | LILRB3 | 11025 | A_23_P368711 | 0.8508 | 0.1733 | |
| SRP007169 | LILRB3 | 11025 | RNAseq | 2.3025 | 0.0132 | |
| SRP008496 | LILRB3 | 11025 | RNAseq | 1.7446 | 0.0089 | |
| SRP064894 | LILRB3 | 11025 | RNAseq | 0.8825 | 0.0119 | |
| SRP133303 | LILRB3 | 11025 | RNAseq | 0.6222 | 0.0118 | |
| SRP159526 | LILRB3 | 11025 | RNAseq | 0.3852 | 0.3671 | |
| SRP193095 | LILRB3 | 11025 | RNAseq | 1.1956 | 0.0000 | |
| SRP219564 | LILRB3 | 11025 | RNAseq | 0.3214 | 0.5458 | |
| TCGA | LILRB3 | 11025 | RNAseq | 0.1897 | 0.4066 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by LILRB3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of LILRB3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LILRB3 | 11025 | 3 | 4 | 23 | |
| GSE20123 | LILRB3 | 11025 | 3 | 3 | 24 | |
| GSE43470 | LILRB3 | 11025 | 2 | 11 | 30 | |
| GSE46452 | LILRB3 | 11025 | 45 | 1 | 13 | |
| GSE47630 | LILRB3 | 11025 | 8 | 6 | 26 | |
| GSE54993 | LILRB3 | 11025 | 17 | 4 | 49 | |
| GSE54994 | LILRB3 | 11025 | 4 | 13 | 36 | |
| GSE60625 | LILRB3 | 11025 | 9 | 0 | 2 | |
| GSE74703 | LILRB3 | 11025 | 2 | 7 | 27 | |
| GSE74704 | LILRB3 | 11025 | 3 | 1 | 16 | |
| TCGA | LILRB3 | 11025 | 19 | 15 | 62 |
Total number of gains: 115; Total number of losses: 65; Total Number of normals: 308.
Somatic mutations of LILRB3:
Generating mutation plots.
Highly correlated genes for LILRB3:
Showing top 20/276 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LILRB3 | EXOC3L2 | 0.735671 | 4 | 0 | 4 |
| LILRB3 | GJD3 | 0.713086 | 4 | 0 | 4 |
| LILRB3 | APOBEC3D | 0.678736 | 3 | 0 | 3 |
| LILRB3 | KCNIP2-AS1 | 0.654705 | 4 | 0 | 4 |
| LILRB3 | HES4 | 0.651133 | 4 | 0 | 3 |
| LILRB3 | LINC01312 | 0.644409 | 3 | 0 | 3 |
| LILRB3 | LILRB1 | 0.643527 | 11 | 0 | 9 |
| LILRB3 | CYBB | 0.637703 | 4 | 0 | 4 |
| LILRB3 | LCN10 | 0.631288 | 4 | 0 | 3 |
| LILRB3 | NLRC4 | 0.628647 | 4 | 0 | 3 |
| LILRB3 | SNORA71B | 0.627006 | 3 | 0 | 3 |
| LILRB3 | LRRC10B | 0.626165 | 3 | 0 | 3 |
| LILRB3 | DLL4 | 0.625698 | 5 | 0 | 4 |
| LILRB3 | KCNS2 | 0.623584 | 3 | 0 | 3 |
| LILRB3 | ANKRD13B | 0.622202 | 4 | 0 | 3 |
| LILRB3 | SSPO | 0.61935 | 3 | 0 | 3 |
| LILRB3 | LILRA6 | 0.617405 | 6 | 0 | 5 |
| LILRB3 | F5 | 0.611709 | 4 | 0 | 3 |
| LILRB3 | LINC00642 | 0.611518 | 4 | 0 | 3 |
| LILRB3 | IL17C | 0.609275 | 3 | 0 | 3 |
For details and further investigation, click here
