NLRC4

 

Full name: NLR family CARD domain containing 4 Alias Symbol: CLAN1|ipaf|CLANA|CLANB|CLANC|CLAND|CLR2.1|CLAN
Type: protein-coding gene Cytoband: 2p22.3
Entrez ID: 58484 HGNC ID: HGNC:16412 Ensembl Gene: ENSG00000091106 OMIM ID: 606831
Drug and gene relationship at DGIdb

 

NLRC4 involved pathways:

KEGG pathway Description View
hsa04621NOD-like receptor signaling pathway
hsa05132Salmonella infection
hsa05134Legionellosis

 

Expression of NLRC4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NLRC4 58484 1552553_a_at 0.4129 0.4609
GSE26886 NLRC4 58484 1552553_a_at 0.1737 0.2807
GSE45670 NLRC4 58484 1552553_a_at 0.0594 0.6623
GSE53622 NLRC4 58484 173408 0.1851 0.0665
GSE53624 NLRC4 58484 173408 0.3498 0.0001
GSE63941 NLRC4 58484 1552554_a_at -0.0061 0.9735
GSE77861 NLRC4 58484 1552554_a_at -0.0615 0.4528
GSE97050 NLRC4 58484 A_23_P119835 0.3535 0.1834
SRP007169 NLRC4 58484 RNAseq 0.7669 0.3420
SRP064894 NLRC4 58484 RNAseq 0.8377 0.0052
SRP133303 NLRC4 58484 RNAseq 0.1754 0.4870
SRP159526 NLRC4 58484 RNAseq 0.5482 0.3044
SRP193095 NLRC4 58484 RNAseq 0.5137 0.0013
SRP219564 NLRC4 58484 RNAseq 0.7325 0.2663
TCGA NLRC4 58484 RNAseq 0.0949 0.6136

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by NLRC4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NLRC4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NLRC4 58484 10 1 19
GSE20123 NLRC4 58484 9 1 20
GSE43470 NLRC4 58484 2 1 40
GSE46452 NLRC4 58484 2 4 53
GSE47630 NLRC4 58484 8 0 32
GSE54993 NLRC4 58484 0 5 65
GSE54994 NLRC4 58484 10 1 42
GSE60625 NLRC4 58484 0 3 8
GSE74703 NLRC4 58484 2 0 34
GSE74704 NLRC4 58484 9 1 10
TCGA NLRC4 58484 36 2 58

Total number of gains: 88; Total number of losses: 19; Total Number of normals: 381.  

 

Somatic mutations of NLRC4:

 

Generating mutation plots.

 

Highly correlated genes for NLRC4:

 

Showing top 20/189 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NLRC4SPI10.718509505
NLRC4PLEK0.679358403
NLRC4C19orf380.676728303
NLRC4SYNPO0.674478303
NLRC4CAMP0.669121403
NLRC4PLCB20.66546504
NLRC4SERPINA120.663977303
NLRC4LCP20.663011505
NLRC4LILRB10.654604605
NLRC4FMNL10.653099404
NLRC4LILRA20.652292303
NLRC4RNF240.650797303
NLRC4PRSS360.6477303
NLRC4MS4A70.64694303
NLRC4MYO1F0.646291707
NLRC4PCBP30.643923303
NLRC4PIK3R50.642554606
NLRC4SLA0.6366605
NLRC4LRRC250.636009303
NLRC4CXCL130.634232403

For details and further investigation, click here