| Full name: Wnt family member 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q13.12 | ||
| Entrez ID: 7471 | HGNC ID: HGNC:12774 | Ensembl Gene: ENSG00000125084 | OMIM ID: 164820 |
| Drug and gene relationship at DGIdb | |||
WNT1 involved pathways:
Expression of WNT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WNT1 | 7471 | 208570_at | 0.2161 | 0.4359 | |
| GSE20347 | WNT1 | 7471 | 208570_at | -0.0495 | 0.5044 | |
| GSE23400 | WNT1 | 7471 | 208570_at | -0.0884 | 0.0247 | |
| GSE26886 | WNT1 | 7471 | 208570_at | 0.3172 | 0.0128 | |
| GSE29001 | WNT1 | 7471 | 208570_at | -0.0155 | 0.9194 | |
| GSE38129 | WNT1 | 7471 | 208570_at | -0.0563 | 0.2910 | |
| GSE45670 | WNT1 | 7471 | 208570_at | 0.0924 | 0.3326 | |
| GSE53622 | WNT1 | 7471 | 12679 | 0.1337 | 0.0796 | |
| GSE53624 | WNT1 | 7471 | 12679 | 0.2684 | 0.0001 | |
| GSE63941 | WNT1 | 7471 | 208570_at | 0.3405 | 0.0106 | |
| GSE77861 | WNT1 | 7471 | 208570_at | 0.0441 | 0.6093 | |
| GSE97050 | WNT1 | 7471 | A_33_P3382588 | 0.1012 | 0.6127 | |
| TCGA | WNT1 | 7471 | RNAseq | 0.6701 | 0.3557 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by WNT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WNT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WNT1 | 7471 | 6 | 1 | 23 | |
| GSE20123 | WNT1 | 7471 | 6 | 1 | 23 | |
| GSE43470 | WNT1 | 7471 | 4 | 1 | 38 | |
| GSE46452 | WNT1 | 7471 | 8 | 1 | 50 | |
| GSE47630 | WNT1 | 7471 | 11 | 2 | 27 | |
| GSE54993 | WNT1 | 7471 | 0 | 5 | 65 | |
| GSE54994 | WNT1 | 7471 | 4 | 1 | 48 | |
| GSE60625 | WNT1 | 7471 | 0 | 0 | 11 | |
| GSE74703 | WNT1 | 7471 | 4 | 1 | 31 | |
| GSE74704 | WNT1 | 7471 | 4 | 1 | 15 | |
| TCGA | WNT1 | 7471 | 16 | 15 | 65 |
Total number of gains: 63; Total number of losses: 29; Total Number of normals: 396.
Somatic mutations of WNT1:
Generating mutation plots.
Highly correlated genes for WNT1:
Showing top 20/255 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WNT1 | CECR2 | 0.736897 | 3 | 0 | 3 |
| WNT1 | SNORA71A | 0.736068 | 3 | 0 | 3 |
| WNT1 | SPTA1 | 0.717815 | 3 | 0 | 3 |
| WNT1 | BRSK1 | 0.693008 | 3 | 0 | 3 |
| WNT1 | ADH6 | 0.685568 | 3 | 0 | 3 |
| WNT1 | LIN28B | 0.685451 | 3 | 0 | 3 |
| WNT1 | OPTC | 0.685269 | 3 | 0 | 3 |
| WNT1 | BMP10 | 0.682693 | 3 | 0 | 3 |
| WNT1 | ADRA1A | 0.680037 | 3 | 0 | 3 |
| WNT1 | TREM1 | 0.679143 | 3 | 0 | 3 |
| WNT1 | OR2H2 | 0.676776 | 3 | 0 | 3 |
| WNT1 | LIM2 | 0.675607 | 5 | 0 | 5 |
| WNT1 | APBA2 | 0.670517 | 3 | 0 | 3 |
| WNT1 | ZNF697 | 0.668076 | 4 | 0 | 3 |
| WNT1 | CHGB | 0.665043 | 3 | 0 | 3 |
| WNT1 | SLC6A18 | 0.653354 | 3 | 0 | 3 |
| WNT1 | METTL7B | 0.652826 | 3 | 0 | 3 |
| WNT1 | TCTE1 | 0.652815 | 4 | 0 | 4 |
| WNT1 | KCNK9 | 0.651345 | 3 | 0 | 3 |
| WNT1 | TNN | 0.64943 | 4 | 0 | 3 |
For details and further investigation, click here
