VAV2

 

Full name: vav guanine nucleotide exchange factor 2 Alias Symbol: 
Type: protein-coding gene Cytoband: 9q34.2
Entrez ID: 7410 HGNC ID: HGNC:12658 Ensembl Gene: ENSG00000160293 OMIM ID: 600428
Drug and gene relationship at DGIdb

 

VAV2 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04510Focal adhesion
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa05205Proteoglycans in cancer

 

Expression of VAV2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 VAV2 7410 226063_at 0.9866 0.0399
GSE20347 VAV2 7410 205536_at 0.3017 0.0006
GSE23400 VAV2 7410 205536_at 0.1905 0.0004
GSE26886 VAV2 7410 226063_at 2.3197 0.0000
GSE29001 VAV2 7410 205536_at 0.0554 0.7635
GSE38129 VAV2 7410 205536_at 0.2815 0.0001
GSE45670 VAV2 7410 226063_at 0.9355 0.0123
GSE53622 VAV2 7410 12447 1.2727 0.0000
GSE53624 VAV2 7410 12447 1.5909 0.0000
GSE63941 VAV2 7410 226063_at 0.7599 0.1456
GSE77861 VAV2 7410 226063_at 0.7709 0.0945
GSE97050 VAV2 7410 A_33_P3390349 -0.0052 0.9864
SRP007169 VAV2 7410 RNAseq 2.8111 0.0000
SRP008496 VAV2 7410 RNAseq 3.4666 0.0000
SRP064894 VAV2 7410 RNAseq 1.6503 0.0000
SRP133303 VAV2 7410 RNAseq 1.3419 0.0000
SRP159526 VAV2 7410 RNAseq 1.0239 0.0076
SRP193095 VAV2 7410 RNAseq 1.0988 0.0000
SRP219564 VAV2 7410 RNAseq 1.0638 0.0059
TCGA VAV2 7410 RNAseq 0.2790 0.0008

Upregulated datasets: 10; Downregulated datasets: 0.  

 

Survival by VAV2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of VAV2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 VAV2 7410 5 7 18
GSE20123 VAV2 7410 5 7 18
GSE43470 VAV2 7410 4 7 32
GSE46452 VAV2 7410 6 13 40
GSE47630 VAV2 7410 6 15 19
GSE54993 VAV2 7410 3 3 64
GSE54994 VAV2 7410 12 9 32
GSE60625 VAV2 7410 0 0 11
GSE74703 VAV2 7410 4 5 27
GSE74704 VAV2 7410 3 5 12
TCGA VAV2 7410 27 27 42

Total number of gains: 75; Total number of losses: 98; Total Number of normals: 315.  

 

Somatic mutations of VAV2:

 

Generating mutation plots.

 

Highly correlated genes for VAV2:

 

Showing top 20/583 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
VAV2SLC18A30.793911303
VAV2SPATA2L0.76085404
VAV2CHRD0.760654303
VAV2PTGER10.75359303
VAV2DPM30.751223303
VAV2ASMTL0.749358303
VAV2USP490.747149303
VAV2HCRTR10.740298303
VAV2CTHRC10.738522606
VAV2ABCC60.735516303
VAV2PRLH0.73416303
VAV2VHL0.727204303
VAV2COL27A10.726612807
VAV2HOXC90.723307505
VAV2C4orf480.721886606
VAV2FBRSL10.72141403
VAV2HSD17B140.721247403
VAV2C1QTNF60.720607606
VAV2CDC42EP20.717698403
VAV2LTB4R20.712792404

For details and further investigation, click here