| Full name: folliculin | Alias Symbol: BHD|MGC17998|MGC23445|DENND8B | ||
| Type: protein-coding gene | Cytoband: 17p11.2 | ||
| Entrez ID: 201163 | HGNC ID: HGNC:27310 | Ensembl Gene: ENSG00000154803 | OMIM ID: 607273 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
FLCN involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04150 | mTOR signaling pathway |
Expression of FLCN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FLCN | 201163 | 1552664_at | -0.0823 | 0.8756 | |
| GSE20347 | FLCN | 201163 | 215645_at | 0.4761 | 0.0009 | |
| GSE23400 | FLCN | 201163 | 215645_at | 0.2700 | 0.0000 | |
| GSE26886 | FLCN | 201163 | 235250_at | 0.8755 | 0.0000 | |
| GSE29001 | FLCN | 201163 | 215645_at | 0.1546 | 0.2636 | |
| GSE38129 | FLCN | 201163 | 215645_at | 0.4038 | 0.0555 | |
| GSE45670 | FLCN | 201163 | 215645_at | 0.3554 | 0.0351 | |
| GSE53622 | FLCN | 201163 | 59160 | 0.4991 | 0.0000 | |
| GSE53624 | FLCN | 201163 | 59160 | 0.3591 | 0.0121 | |
| GSE63941 | FLCN | 201163 | 1552664_at | -0.0225 | 0.9722 | |
| GSE77861 | FLCN | 201163 | 215645_at | 0.0117 | 0.9657 | |
| GSE97050 | FLCN | 201163 | A_33_P3359763 | 0.1916 | 0.4116 | |
| SRP007169 | FLCN | 201163 | RNAseq | 0.8503 | 0.0838 | |
| SRP008496 | FLCN | 201163 | RNAseq | 0.6375 | 0.0385 | |
| SRP064894 | FLCN | 201163 | RNAseq | 0.8155 | 0.0040 | |
| SRP133303 | FLCN | 201163 | RNAseq | 0.2249 | 0.1345 | |
| SRP159526 | FLCN | 201163 | RNAseq | 0.3421 | 0.2256 | |
| SRP193095 | FLCN | 201163 | RNAseq | 0.4175 | 0.0002 | |
| SRP219564 | FLCN | 201163 | RNAseq | 0.1891 | 0.6224 | |
| TCGA | FLCN | 201163 | RNAseq | -0.1251 | 0.0180 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by FLCN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FLCN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FLCN | 201163 | 3 | 3 | 24 | |
| GSE20123 | FLCN | 201163 | 3 | 4 | 23 | |
| GSE43470 | FLCN | 201163 | 2 | 5 | 36 | |
| GSE46452 | FLCN | 201163 | 34 | 1 | 24 | |
| GSE47630 | FLCN | 201163 | 7 | 1 | 32 | |
| GSE54993 | FLCN | 201163 | 3 | 3 | 64 | |
| GSE54994 | FLCN | 201163 | 6 | 5 | 42 | |
| GSE60625 | FLCN | 201163 | 4 | 0 | 7 | |
| GSE74703 | FLCN | 201163 | 2 | 2 | 32 | |
| GSE74704 | FLCN | 201163 | 2 | 1 | 17 | |
| TCGA | FLCN | 201163 | 18 | 23 | 55 |
Total number of gains: 84; Total number of losses: 48; Total Number of normals: 356.
Somatic mutations of FLCN:
Generating mutation plots.
Highly correlated genes for FLCN:
Showing top 20/125 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FLCN | CDH4 | 0.736857 | 3 | 0 | 3 |
| FLCN | CDC42EP2 | 0.731101 | 3 | 0 | 3 |
| FLCN | HOXC9 | 0.727056 | 3 | 0 | 3 |
| FLCN | VHL | 0.719322 | 3 | 0 | 3 |
| FLCN | C1QTNF6 | 0.713427 | 3 | 0 | 3 |
| FLCN | MAGEA8 | 0.696135 | 3 | 0 | 3 |
| FLCN | NAT14 | 0.675456 | 4 | 0 | 3 |
| FLCN | ZDHHC8 | 0.671258 | 3 | 0 | 3 |
| FLCN | AGER | 0.663742 | 3 | 0 | 3 |
| FLCN | CLTCL1 | 0.661901 | 4 | 0 | 3 |
| FLCN | LIN28B | 0.64856 | 4 | 0 | 4 |
| FLCN | FUT7 | 0.643419 | 4 | 0 | 4 |
| FLCN | NEUROD2 | 0.641975 | 5 | 0 | 5 |
| FLCN | VCX2 | 0.640436 | 4 | 0 | 3 |
| FLCN | CHGB | 0.640166 | 4 | 0 | 3 |
| FLCN | OR10H1 | 0.635984 | 5 | 0 | 4 |
| FLCN | CNGB1 | 0.632951 | 4 | 0 | 3 |
| FLCN | ATP8B3 | 0.627937 | 6 | 0 | 4 |
| FLCN | NOX1 | 0.625251 | 5 | 0 | 4 |
| FLCN | MC1R | 0.625215 | 5 | 0 | 4 |
For details and further investigation, click here
