| Full name: death associated protein kinase 2 | Alias Symbol: DRP-1|MGC119312 | ||
| Type: protein-coding gene | Cytoband: 15q22.31 | ||
| Entrez ID: 23604 | HGNC ID: HGNC:2675 | Ensembl Gene: ENSG00000035664 | OMIM ID: 616567 |
| Drug and gene relationship at DGIdb | |||
DAPK2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05200 | Pathways in cancer | |
| hsa05219 | Bladder cancer |
Expression of DAPK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DAPK2 | 23604 | 206324_s_at | 0.2467 | 0.4865 | |
| GSE20347 | DAPK2 | 23604 | 206324_s_at | 0.2447 | 0.0181 | |
| GSE23400 | DAPK2 | 23604 | 206324_s_at | -0.0460 | 0.1574 | |
| GSE26886 | DAPK2 | 23604 | 206324_s_at | 0.3531 | 0.0270 | |
| GSE29001 | DAPK2 | 23604 | 206324_s_at | -0.0447 | 0.8492 | |
| GSE38129 | DAPK2 | 23604 | 206324_s_at | 0.0784 | 0.6101 | |
| GSE45670 | DAPK2 | 23604 | 206324_s_at | 0.2448 | 0.1018 | |
| GSE53622 | DAPK2 | 23604 | 67563 | 0.1863 | 0.1795 | |
| GSE53624 | DAPK2 | 23604 | 67563 | -0.1256 | 0.2800 | |
| GSE63941 | DAPK2 | 23604 | 215184_at | -0.3247 | 0.4883 | |
| GSE77861 | DAPK2 | 23604 | 206324_s_at | -0.0642 | 0.5627 | |
| GSE97050 | DAPK2 | 23604 | A_24_P10233 | 0.1851 | 0.5837 | |
| SRP007169 | DAPK2 | 23604 | RNAseq | -1.4237 | 0.0032 | |
| SRP064894 | DAPK2 | 23604 | RNAseq | -0.0400 | 0.8549 | |
| SRP133303 | DAPK2 | 23604 | RNAseq | 0.1555 | 0.4412 | |
| SRP159526 | DAPK2 | 23604 | RNAseq | 0.6204 | 0.1277 | |
| SRP193095 | DAPK2 | 23604 | RNAseq | -0.2584 | 0.3456 | |
| SRP219564 | DAPK2 | 23604 | RNAseq | 0.0961 | 0.8726 | |
| TCGA | DAPK2 | 23604 | RNAseq | -0.4640 | 0.0047 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by DAPK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DAPK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DAPK2 | 23604 | 7 | 3 | 20 | |
| GSE20123 | DAPK2 | 23604 | 7 | 3 | 20 | |
| GSE43470 | DAPK2 | 23604 | 4 | 6 | 33 | |
| GSE46452 | DAPK2 | 23604 | 3 | 7 | 49 | |
| GSE47630 | DAPK2 | 23604 | 8 | 10 | 22 | |
| GSE54993 | DAPK2 | 23604 | 5 | 6 | 59 | |
| GSE54994 | DAPK2 | 23604 | 6 | 8 | 39 | |
| GSE60625 | DAPK2 | 23604 | 4 | 0 | 7 | |
| GSE74703 | DAPK2 | 23604 | 4 | 3 | 29 | |
| GSE74704 | DAPK2 | 23604 | 3 | 3 | 14 | |
| TCGA | DAPK2 | 23604 | 10 | 18 | 68 |
Total number of gains: 61; Total number of losses: 67; Total Number of normals: 360.
Somatic mutations of DAPK2:
Generating mutation plots.
Highly correlated genes for DAPK2:
Showing top 20/199 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DAPK2 | NAT14 | 0.704426 | 3 | 0 | 3 |
| DAPK2 | ST3GAL1 | 0.686942 | 3 | 0 | 3 |
| DAPK2 | FBLN7 | 0.684661 | 4 | 0 | 3 |
| DAPK2 | CAPN13 | 0.681753 | 4 | 0 | 3 |
| DAPK2 | CFC1 | 0.677068 | 3 | 0 | 3 |
| DAPK2 | C1QTNF6 | 0.661239 | 3 | 0 | 3 |
| DAPK2 | TEX22 | 0.654223 | 4 | 0 | 3 |
| DAPK2 | AICDA | 0.653417 | 3 | 0 | 3 |
| DAPK2 | LONP1 | 0.651504 | 3 | 0 | 3 |
| DAPK2 | JAKMIP1 | 0.651244 | 3 | 0 | 3 |
| DAPK2 | CYP4Z1 | 0.64653 | 4 | 0 | 3 |
| DAPK2 | P4HA3 | 0.645133 | 3 | 0 | 3 |
| DAPK2 | ATP8B3 | 0.641087 | 5 | 0 | 5 |
| DAPK2 | KISS1R | 0.636628 | 3 | 0 | 3 |
| DAPK2 | MMP17 | 0.63184 | 3 | 0 | 3 |
| DAPK2 | KCNAB3 | 0.628642 | 6 | 0 | 5 |
| DAPK2 | CRABP1 | 0.626205 | 4 | 0 | 3 |
| DAPK2 | CPB1 | 0.621649 | 4 | 0 | 3 |
| DAPK2 | DEFA4 | 0.620725 | 3 | 0 | 3 |
| DAPK2 | C4BPA | 0.618931 | 6 | 0 | 4 |
For details and further investigation, click here
