| Full name: hydroxysteroid 17-beta dehydrogenase 3 | Alias Symbol: SDR12C2 | ||
| Type: protein-coding gene | Cytoband: 9q22.32 | ||
| Entrez ID: 3293 | HGNC ID: HGNC:5212 | Ensembl Gene: ENSG00000130948 | OMIM ID: 605573 |
| Drug and gene relationship at DGIdb | |||
Expression of HSD17B3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSD17B3 | 3293 | 206985_at | 0.0108 | 0.9846 | |
| GSE20347 | HSD17B3 | 3293 | 206985_at | 0.0675 | 0.5604 | |
| GSE23400 | HSD17B3 | 3293 | 206985_at | -0.0024 | 0.9716 | |
| GSE26886 | HSD17B3 | 3293 | 206985_at | 0.4183 | 0.0802 | |
| GSE29001 | HSD17B3 | 3293 | 206985_at | 0.0625 | 0.7789 | |
| GSE38129 | HSD17B3 | 3293 | 206985_at | 0.0590 | 0.5730 | |
| GSE45670 | HSD17B3 | 3293 | 206985_at | 0.1314 | 0.5463 | |
| GSE53622 | HSD17B3 | 3293 | 139151 | 0.1792 | 0.0561 | |
| GSE53624 | HSD17B3 | 3293 | 139151 | 0.5456 | 0.0000 | |
| GSE63941 | HSD17B3 | 3293 | 206985_at | 0.2841 | 0.5793 | |
| GSE77861 | HSD17B3 | 3293 | 206985_at | 0.0719 | 0.6175 | |
| GSE97050 | HSD17B3 | 3293 | A_33_P3418662 | -0.1120 | 0.6887 | |
| SRP159526 | HSD17B3 | 3293 | RNAseq | 1.0206 | 0.1053 | |
| SRP219564 | HSD17B3 | 3293 | RNAseq | -0.0944 | 0.8696 | |
| TCGA | HSD17B3 | 3293 | RNAseq | 1.4838 | 0.0520 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HSD17B3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSD17B3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSD17B3 | 3293 | 6 | 7 | 17 | |
| GSE20123 | HSD17B3 | 3293 | 6 | 7 | 17 | |
| GSE43470 | HSD17B3 | 3293 | 6 | 3 | 34 | |
| GSE46452 | HSD17B3 | 3293 | 6 | 14 | 39 | |
| GSE47630 | HSD17B3 | 3293 | 1 | 17 | 22 | |
| GSE54993 | HSD17B3 | 3293 | 3 | 2 | 65 | |
| GSE54994 | HSD17B3 | 3293 | 8 | 11 | 34 | |
| GSE60625 | HSD17B3 | 3293 | 0 | 0 | 11 | |
| GSE74703 | HSD17B3 | 3293 | 5 | 3 | 28 | |
| GSE74704 | HSD17B3 | 3293 | 3 | 5 | 12 | |
| TCGA | HSD17B3 | 3293 | 24 | 23 | 49 |
Total number of gains: 68; Total number of losses: 92; Total Number of normals: 328.
Somatic mutations of HSD17B3:
Generating mutation plots.
Highly correlated genes for HSD17B3:
Showing top 20/131 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSD17B3 | KIRREL2 | 0.775364 | 3 | 0 | 3 |
| HSD17B3 | C9orf153 | 0.743266 | 3 | 0 | 3 |
| HSD17B3 | ZNF646 | 0.739355 | 3 | 0 | 3 |
| HSD17B3 | CDH4 | 0.729212 | 3 | 0 | 3 |
| HSD17B3 | NKX6-3 | 0.727064 | 3 | 0 | 3 |
| HSD17B3 | JAKMIP3 | 0.720046 | 3 | 0 | 3 |
| HSD17B3 | GABRB1 | 0.719447 | 3 | 0 | 3 |
| HSD17B3 | NTNG2 | 0.711929 | 5 | 0 | 5 |
| HSD17B3 | MRGPRG | 0.710442 | 3 | 0 | 3 |
| HSD17B3 | FOXB1 | 0.703933 | 3 | 0 | 3 |
| HSD17B3 | TNFRSF14 | 0.699134 | 4 | 0 | 3 |
| HSD17B3 | C19orf71 | 0.697039 | 3 | 0 | 3 |
| HSD17B3 | C2CD4D | 0.695213 | 3 | 0 | 3 |
| HSD17B3 | ANO7 | 0.694364 | 3 | 0 | 3 |
| HSD17B3 | ATP2B2 | 0.692686 | 4 | 0 | 3 |
| HSD17B3 | FFAR1 | 0.688601 | 4 | 0 | 4 |
| HSD17B3 | RBM43 | 0.68703 | 3 | 0 | 3 |
| HSD17B3 | HOTAIR | 0.683344 | 4 | 0 | 3 |
| HSD17B3 | XRCC2 | 0.675718 | 4 | 0 | 4 |
| HSD17B3 | CLCNKB | 0.669571 | 3 | 0 | 3 |
For details and further investigation, click here
