| Full name: endoglin | Alias Symbol: END|HHT1|CD105 | ||
| Type: protein-coding gene | Cytoband: 9q34.11 | ||
| Entrez ID: 2022 | HGNC ID: HGNC:3349 | Ensembl Gene: ENSG00000106991 | OMIM ID: 131195 |
| Drug and gene relationship at DGIdb | |||
Expression of ENG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ENG | 2022 | 201809_s_at | 0.2719 | 0.6268 | |
| GSE20347 | ENG | 2022 | 201809_s_at | 0.0931 | 0.3476 | |
| GSE23400 | ENG | 2022 | 201809_s_at | 0.0447 | 0.5661 | |
| GSE26886 | ENG | 2022 | 201809_s_at | 0.4681 | 0.0136 | |
| GSE29001 | ENG | 2022 | 201809_s_at | 0.1391 | 0.5369 | |
| GSE38129 | ENG | 2022 | 201809_s_at | -0.0704 | 0.7997 | |
| GSE45670 | ENG | 2022 | 201809_s_at | 0.0257 | 0.9381 | |
| GSE53622 | ENG | 2022 | 93287 | -0.0127 | 0.8899 | |
| GSE53624 | ENG | 2022 | 93287 | 0.2417 | 0.0004 | |
| GSE63941 | ENG | 2022 | 201809_s_at | -3.7197 | 0.0000 | |
| GSE77861 | ENG | 2022 | 201809_s_at | 0.2877 | 0.2368 | |
| GSE97050 | ENG | 2022 | A_23_P83328 | 0.7161 | 0.1344 | |
| SRP007169 | ENG | 2022 | RNAseq | 1.2307 | 0.0153 | |
| SRP008496 | ENG | 2022 | RNAseq | 1.2836 | 0.0022 | |
| SRP064894 | ENG | 2022 | RNAseq | 0.6488 | 0.0104 | |
| SRP133303 | ENG | 2022 | RNAseq | 0.1072 | 0.6102 | |
| SRP159526 | ENG | 2022 | RNAseq | 0.5780 | 0.0973 | |
| SRP193095 | ENG | 2022 | RNAseq | 1.1756 | 0.0000 | |
| SRP219564 | ENG | 2022 | RNAseq | 0.4251 | 0.4655 | |
| TCGA | ENG | 2022 | RNAseq | -0.0446 | 0.4973 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by ENG expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ENG:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ENG | 2022 | 6 | 9 | 15 | |
| GSE20123 | ENG | 2022 | 6 | 9 | 15 | |
| GSE43470 | ENG | 2022 | 5 | 6 | 32 | |
| GSE46452 | ENG | 2022 | 6 | 13 | 40 | |
| GSE47630 | ENG | 2022 | 3 | 16 | 21 | |
| GSE54993 | ENG | 2022 | 3 | 3 | 64 | |
| GSE54994 | ENG | 2022 | 11 | 8 | 34 | |
| GSE60625 | ENG | 2022 | 0 | 0 | 11 | |
| GSE74703 | ENG | 2022 | 5 | 4 | 27 | |
| GSE74704 | ENG | 2022 | 3 | 7 | 10 | |
| TCGA | ENG | 2022 | 27 | 25 | 44 |
Total number of gains: 75; Total number of losses: 100; Total Number of normals: 313.
Somatic mutations of ENG:
Generating mutation plots.
Highly correlated genes for ENG:
Showing top 20/1104 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ENG | ENTPD4 | 0.842324 | 3 | 0 | 3 |
| ENG | ARHGAP17 | 0.82303 | 3 | 0 | 3 |
| ENG | C20orf194 | 0.810835 | 3 | 0 | 3 |
| ENG | TK2 | 0.795852 | 4 | 0 | 4 |
| ENG | FAM167B | 0.764832 | 5 | 0 | 5 |
| ENG | RFTN2 | 0.763689 | 3 | 0 | 3 |
| ENG | IL33 | 0.758487 | 4 | 0 | 4 |
| ENG | PACS1 | 0.754799 | 3 | 0 | 3 |
| ENG | COL15A1 | 0.750194 | 11 | 0 | 11 |
| ENG | SYNC | 0.747266 | 4 | 0 | 4 |
| ENG | TIE1 | 0.742849 | 10 | 0 | 9 |
| ENG | B3GALT2 | 0.739947 | 4 | 0 | 4 |
| ENG | RCN2 | 0.739819 | 3 | 0 | 3 |
| ENG | IMPDH1 | 0.739266 | 4 | 0 | 4 |
| ENG | NFIC | 0.736634 | 4 | 0 | 4 |
| ENG | SSC5D | 0.73408 | 3 | 0 | 3 |
| ENG | SNX25 | 0.729754 | 3 | 0 | 3 |
| ENG | ICAM5 | 0.727479 | 4 | 0 | 4 |
| ENG | ERLEC1 | 0.727222 | 4 | 0 | 4 |
| ENG | HIC1 | 0.726625 | 7 | 0 | 7 |
For details and further investigation, click here
