| Full name: LDL receptor related protein 5 | Alias Symbol: LR3|BMND1|HBM|OPS|OPTA1|VBCH2|EVR4 | ||
| Type: protein-coding gene | Cytoband: 11q13.2 | ||
| Entrez ID: 4041 | HGNC ID: HGNC:6697 | Ensembl Gene: ENSG00000162337 | OMIM ID: 603506 |
| Drug and gene relationship at DGIdb | |||
LRP5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04150 | mTOR signaling pathway | |
| hsa04310 | Wnt signaling pathway |
Expression of LRP5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRP5 | 4041 | 209468_at | 0.8955 | 0.0591 | |
| GSE20347 | LRP5 | 4041 | 209468_at | 0.8877 | 0.0017 | |
| GSE23400 | LRP5 | 4041 | 209468_at | 0.4036 | 0.0000 | |
| GSE26886 | LRP5 | 4041 | 229591_at | 0.0547 | 0.7255 | |
| GSE29001 | LRP5 | 4041 | 209468_at | -0.0143 | 0.9361 | |
| GSE38129 | LRP5 | 4041 | 209468_at | 0.6204 | 0.0114 | |
| GSE45670 | LRP5 | 4041 | 209468_at | 0.0028 | 0.9867 | |
| GSE53622 | LRP5 | 4041 | 41761 | 0.3150 | 0.0049 | |
| GSE53624 | LRP5 | 4041 | 41761 | 0.5511 | 0.0000 | |
| GSE63941 | LRP5 | 4041 | 209468_at | 2.5573 | 0.0012 | |
| GSE77861 | LRP5 | 4041 | 209468_at | 0.4922 | 0.1943 | |
| GSE97050 | LRP5 | 4041 | A_23_P1505 | 0.0823 | 0.9000 | |
| SRP007169 | LRP5 | 4041 | RNAseq | 0.8132 | 0.0603 | |
| SRP008496 | LRP5 | 4041 | RNAseq | 1.1681 | 0.0002 | |
| SRP064894 | LRP5 | 4041 | RNAseq | -0.3955 | 0.0780 | |
| SRP133303 | LRP5 | 4041 | RNAseq | -0.1883 | 0.4435 | |
| SRP159526 | LRP5 | 4041 | RNAseq | 1.1976 | 0.0014 | |
| SRP193095 | LRP5 | 4041 | RNAseq | 0.4596 | 0.0618 | |
| SRP219564 | LRP5 | 4041 | RNAseq | -0.0005 | 0.9991 | |
| TCGA | LRP5 | 4041 | RNAseq | -0.0638 | 0.3963 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by LRP5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRP5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRP5 | 4041 | 10 | 3 | 17 | |
| GSE20123 | LRP5 | 4041 | 11 | 3 | 16 | |
| GSE43470 | LRP5 | 4041 | 6 | 3 | 34 | |
| GSE46452 | LRP5 | 4041 | 21 | 2 | 36 | |
| GSE47630 | LRP5 | 4041 | 13 | 3 | 24 | |
| GSE54993 | LRP5 | 4041 | 2 | 6 | 62 | |
| GSE54994 | LRP5 | 4041 | 17 | 4 | 32 | |
| GSE60625 | LRP5 | 4041 | 0 | 3 | 8 | |
| GSE74703 | LRP5 | 4041 | 5 | 2 | 29 | |
| GSE74704 | LRP5 | 4041 | 8 | 1 | 11 | |
| TCGA | LRP5 | 4041 | 36 | 8 | 52 |
Total number of gains: 129; Total number of losses: 38; Total Number of normals: 321.
Somatic mutations of LRP5:
Generating mutation plots.
Highly correlated genes for LRP5:
Showing top 20/742 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRP5 | CMTM4 | 0.789696 | 4 | 0 | 4 |
| LRP5 | UTP23 | 0.751309 | 3 | 0 | 3 |
| LRP5 | PLEKHH1 | 0.735401 | 3 | 0 | 3 |
| LRP5 | DGCR2 | 0.726943 | 3 | 0 | 3 |
| LRP5 | MISP | 0.72068 | 4 | 0 | 4 |
| LRP5 | PROX1 | 0.720561 | 3 | 0 | 3 |
| LRP5 | AMMECR1L | 0.718564 | 3 | 0 | 3 |
| LRP5 | CPNE8 | 0.717062 | 3 | 0 | 3 |
| LRP5 | KRTCAP2 | 0.716605 | 3 | 0 | 3 |
| LRP5 | RBM17 | 0.716005 | 3 | 0 | 3 |
| LRP5 | COLEC11 | 0.70916 | 4 | 0 | 4 |
| LRP5 | ZNF202 | 0.708426 | 3 | 0 | 3 |
| LRP5 | TSEN15 | 0.706545 | 3 | 0 | 3 |
| LRP5 | PRR12 | 0.699503 | 3 | 0 | 3 |
| LRP5 | PET117 | 0.69728 | 3 | 0 | 3 |
| LRP5 | NPNT | 0.696448 | 4 | 0 | 3 |
| LRP5 | GRWD1 | 0.69431 | 3 | 0 | 3 |
| LRP5 | KHNYN | 0.691452 | 4 | 0 | 4 |
| LRP5 | DNAJA3 | 0.684446 | 3 | 0 | 3 |
| LRP5 | NOM1 | 0.681832 | 3 | 0 | 3 |
For details and further investigation, click here
