| Full name: LDL receptor related protein associated protein 1 | Alias Symbol: HBP44 | ||
| Type: protein-coding gene | Cytoband: 4p16.3 | ||
| Entrez ID: 4043 | HGNC ID: HGNC:6701 | Ensembl Gene: ENSG00000163956 | OMIM ID: 104225 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of LRPAP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRPAP1 | 4043 | 201186_at | 0.1655 | 0.7359 | |
| GSE20347 | LRPAP1 | 4043 | 201186_at | 0.2454 | 0.0608 | |
| GSE23400 | LRPAP1 | 4043 | 201186_at | 0.0997 | 0.1230 | |
| GSE26886 | LRPAP1 | 4043 | 201186_at | 0.8275 | 0.0000 | |
| GSE29001 | LRPAP1 | 4043 | 201186_at | 0.2739 | 0.1772 | |
| GSE38129 | LRPAP1 | 4043 | 201186_at | 0.0948 | 0.4756 | |
| GSE45670 | LRPAP1 | 4043 | 201186_at | 0.1490 | 0.3516 | |
| GSE53622 | LRPAP1 | 4043 | 61986 | 0.0688 | 0.3530 | |
| GSE53624 | LRPAP1 | 4043 | 23492 | 0.1780 | 0.0038 | |
| GSE63941 | LRPAP1 | 4043 | 201186_at | -1.0584 | 0.0077 | |
| GSE77861 | LRPAP1 | 4043 | 201186_at | 0.0692 | 0.6689 | |
| GSE97050 | LRPAP1 | 4043 | A_23_P29851 | -0.0063 | 0.9812 | |
| SRP007169 | LRPAP1 | 4043 | RNAseq | 0.3044 | 0.3827 | |
| SRP008496 | LRPAP1 | 4043 | RNAseq | 0.6500 | 0.1592 | |
| SRP064894 | LRPAP1 | 4043 | RNAseq | 0.4252 | 0.1921 | |
| SRP133303 | LRPAP1 | 4043 | RNAseq | 0.1224 | 0.3253 | |
| SRP159526 | LRPAP1 | 4043 | RNAseq | 0.3472 | 0.1914 | |
| SRP193095 | LRPAP1 | 4043 | RNAseq | 0.0813 | 0.4503 | |
| SRP219564 | LRPAP1 | 4043 | RNAseq | 0.2423 | 0.5077 | |
| TCGA | LRPAP1 | 4043 | RNAseq | -0.1792 | 0.0007 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by LRPAP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRPAP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRPAP1 | 4043 | 0 | 17 | 13 | |
| GSE20123 | LRPAP1 | 4043 | 0 | 17 | 13 | |
| GSE43470 | LRPAP1 | 4043 | 0 | 18 | 25 | |
| GSE46452 | LRPAP1 | 4043 | 1 | 36 | 22 | |
| GSE47630 | LRPAP1 | 4043 | 1 | 19 | 20 | |
| GSE54993 | LRPAP1 | 4043 | 10 | 0 | 60 | |
| GSE54994 | LRPAP1 | 4043 | 3 | 12 | 38 | |
| GSE60625 | LRPAP1 | 4043 | 0 | 0 | 11 | |
| GSE74703 | LRPAP1 | 4043 | 0 | 14 | 22 | |
| GSE74704 | LRPAP1 | 4043 | 0 | 9 | 11 | |
| TCGA | LRPAP1 | 4043 | 7 | 47 | 42 |
Total number of gains: 22; Total number of losses: 189; Total Number of normals: 277.
Somatic mutations of LRPAP1:
Generating mutation plots.
Highly correlated genes for LRPAP1:
Showing top 20/561 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRPAP1 | C11orf96 | 0.773369 | 3 | 0 | 3 |
| LRPAP1 | LNP1 | 0.747136 | 3 | 0 | 3 |
| LRPAP1 | GPR161 | 0.724451 | 3 | 0 | 3 |
| LRPAP1 | IL17RD | 0.703846 | 3 | 0 | 3 |
| LRPAP1 | ASB7 | 0.70328 | 3 | 0 | 3 |
| LRPAP1 | LAMA4 | 0.697878 | 4 | 0 | 3 |
| LRPAP1 | ALKBH6 | 0.69677 | 3 | 0 | 3 |
| LRPAP1 | ZNF703 | 0.69615 | 4 | 0 | 4 |
| LRPAP1 | CHST14 | 0.692181 | 3 | 0 | 3 |
| LRPAP1 | SERPINF2 | 0.688352 | 3 | 0 | 3 |
| LRPAP1 | IMMP1L | 0.685787 | 3 | 0 | 3 |
| LRPAP1 | ECE1 | 0.683913 | 4 | 0 | 4 |
| LRPAP1 | PRR12 | 0.676173 | 3 | 0 | 3 |
| LRPAP1 | CASC4 | 0.670798 | 5 | 0 | 3 |
| LRPAP1 | DNTTIP1 | 0.668874 | 3 | 0 | 3 |
| LRPAP1 | SOBP | 0.664479 | 3 | 0 | 3 |
| LRPAP1 | DDX24 | 0.661576 | 4 | 0 | 3 |
| LRPAP1 | RAB31 | 0.659091 | 3 | 0 | 3 |
| LRPAP1 | NGF | 0.65871 | 4 | 0 | 4 |
| LRPAP1 | ANTXR2 | 0.65783 | 4 | 0 | 3 |
For details and further investigation, click here
