| Full name: high mobility group nucleosomal binding domain 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p36.11 | ||
| Entrez ID: 3151 | HGNC ID: HGNC:4986 | Ensembl Gene: ENSG00000198830 | OMIM ID: 163910 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of HMGN2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HMGN2 | 3151 | 208668_x_at | 0.0823 | 0.8171 | |
| GSE20347 | HMGN2 | 3151 | 208668_x_at | 0.2683 | 0.0862 | |
| GSE23400 | HMGN2 | 3151 | 208668_x_at | 0.4255 | 0.0000 | |
| GSE26886 | HMGN2 | 3151 | 208668_x_at | -0.0390 | 0.8442 | |
| GSE29001 | HMGN2 | 3151 | 208668_x_at | 0.3856 | 0.0749 | |
| GSE38129 | HMGN2 | 3151 | 208668_x_at | 0.2714 | 0.0211 | |
| GSE45670 | HMGN2 | 3151 | 208668_x_at | 0.0438 | 0.8185 | |
| GSE53622 | HMGN2 | 3151 | 80386 | 0.1563 | 0.0075 | |
| GSE53624 | HMGN2 | 3151 | 80386 | 0.4865 | 0.0000 | |
| GSE63941 | HMGN2 | 3151 | 208668_x_at | 1.1192 | 0.0027 | |
| GSE77861 | HMGN2 | 3151 | 208668_x_at | -0.1992 | 0.3746 | |
| GSE97050 | HMGN2 | 3151 | A_32_P41487 | -0.0810 | 0.8046 | |
| SRP007169 | HMGN2 | 3151 | RNAseq | 0.6006 | 0.1676 | |
| SRP008496 | HMGN2 | 3151 | RNAseq | 0.5772 | 0.0132 | |
| SRP064894 | HMGN2 | 3151 | RNAseq | 0.8964 | 0.0013 | |
| SRP133303 | HMGN2 | 3151 | RNAseq | 0.3361 | 0.0022 | |
| SRP159526 | HMGN2 | 3151 | RNAseq | 0.6048 | 0.1594 | |
| SRP193095 | HMGN2 | 3151 | RNAseq | -0.0392 | 0.6859 | |
| SRP219564 | HMGN2 | 3151 | RNAseq | 0.5262 | 0.0589 | |
| TCGA | HMGN2 | 3151 | RNAseq | 0.1818 | 0.0001 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by HMGN2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HMGN2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HMGN2 | 3151 | 0 | 6 | 24 | |
| GSE20123 | HMGN2 | 3151 | 0 | 5 | 25 | |
| GSE43470 | HMGN2 | 3151 | 2 | 6 | 35 | |
| GSE46452 | HMGN2 | 3151 | 5 | 1 | 53 | |
| GSE47630 | HMGN2 | 3151 | 8 | 3 | 29 | |
| GSE54993 | HMGN2 | 3151 | 2 | 1 | 67 | |
| GSE54994 | HMGN2 | 3151 | 10 | 4 | 39 | |
| GSE60625 | HMGN2 | 3151 | 0 | 0 | 11 | |
| GSE74703 | HMGN2 | 3151 | 1 | 4 | 31 | |
| GSE74704 | HMGN2 | 3151 | 0 | 0 | 20 | |
| TCGA | HMGN2 | 3151 | 9 | 24 | 63 |
Total number of gains: 37; Total number of losses: 54; Total Number of normals: 397.
Somatic mutations of HMGN2:
Generating mutation plots.
Highly correlated genes for HMGN2:
Showing top 20/671 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HMGN2 | TRMT5 | 0.89519 | 13 | 0 | 12 |
| HMGN2 | LRRC14 | 0.728922 | 3 | 0 | 3 |
| HMGN2 | ELAVL1 | 0.718765 | 5 | 0 | 5 |
| HMGN2 | VPS28 | 0.714879 | 3 | 0 | 3 |
| HMGN2 | UNG | 0.712805 | 5 | 0 | 5 |
| HMGN2 | RPA2 | 0.684007 | 10 | 0 | 8 |
| HMGN2 | IDH3G | 0.678772 | 3 | 0 | 3 |
| HMGN2 | METAP2 | 0.675157 | 4 | 0 | 3 |
| HMGN2 | SETD3 | 0.671465 | 4 | 0 | 4 |
| HMGN2 | SF3B4 | 0.671195 | 3 | 0 | 3 |
| HMGN2 | ATXN7L3B | 0.66951 | 3 | 0 | 3 |
| HMGN2 | TRIM47 | 0.665806 | 4 | 0 | 3 |
| HMGN2 | DEK | 0.6652 | 10 | 0 | 8 |
| HMGN2 | HP1BP3 | 0.664543 | 4 | 0 | 4 |
| HMGN2 | ARL6IP6 | 0.660801 | 3 | 0 | 3 |
| HMGN2 | ZNF579 | 0.657647 | 3 | 0 | 3 |
| HMGN2 | DDX11 | 0.656147 | 3 | 0 | 3 |
| HMGN2 | RNF130 | 0.653123 | 5 | 0 | 4 |
| HMGN2 | USP1 | 0.653024 | 11 | 0 | 8 |
| HMGN2 | CDK1 | 0.652973 | 4 | 0 | 3 |
For details and further investigation, click here
