| Full name: FTO alpha-ketoglutarate dependent dioxygenase | Alias Symbol: KIAA1752|MGC5149|ALKBH9 | ||
| Type: protein-coding gene | Cytoband: 16q12.2 | ||
| Entrez ID: 79068 | HGNC ID: HGNC:24678 | Ensembl Gene: ENSG00000140718 | OMIM ID: 610966 |
| Drug and gene relationship at DGIdb | |||
Expression of FTO:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FTO | 79068 | 209702_at | -0.0568 | 0.9274 | |
| GSE20347 | FTO | 79068 | 209702_at | 0.3521 | 0.0134 | |
| GSE23400 | FTO | 79068 | 209702_at | 0.3314 | 0.0003 | |
| GSE26886 | FTO | 79068 | 209702_at | 0.7207 | 0.0001 | |
| GSE29001 | FTO | 79068 | 209702_at | 0.1668 | 0.5651 | |
| GSE38129 | FTO | 79068 | 209702_at | 0.1661 | 0.3903 | |
| GSE45670 | FTO | 79068 | 209702_at | -0.0292 | 0.8884 | |
| GSE53622 | FTO | 79068 | 34295 | 0.1964 | 0.0037 | |
| GSE53624 | FTO | 79068 | 34295 | 0.2688 | 0.0001 | |
| GSE63941 | FTO | 79068 | 209702_at | 0.2520 | 0.5679 | |
| GSE77861 | FTO | 79068 | 209702_at | 0.3590 | 0.1803 | |
| GSE97050 | FTO | 79068 | A_23_P113184 | 0.2720 | 0.2451 | |
| SRP007169 | FTO | 79068 | RNAseq | 1.4831 | 0.0013 | |
| SRP008496 | FTO | 79068 | RNAseq | 1.5314 | 0.0001 | |
| SRP064894 | FTO | 79068 | RNAseq | 0.3059 | 0.1411 | |
| SRP133303 | FTO | 79068 | RNAseq | 0.4702 | 0.0001 | |
| SRP159526 | FTO | 79068 | RNAseq | 0.2915 | 0.0737 | |
| SRP193095 | FTO | 79068 | RNAseq | 0.4337 | 0.0000 | |
| SRP219564 | FTO | 79068 | RNAseq | 0.2580 | 0.6047 | |
| TCGA | FTO | 79068 | RNAseq | 0.0106 | 0.8254 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by FTO expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FTO:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FTO | 79068 | 3 | 0 | 27 | |
| GSE20123 | FTO | 79068 | 3 | 0 | 27 | |
| GSE43470 | FTO | 79068 | 2 | 7 | 34 | |
| GSE46452 | FTO | 79068 | 38 | 1 | 20 | |
| GSE47630 | FTO | 79068 | 11 | 7 | 22 | |
| GSE54993 | FTO | 79068 | 2 | 5 | 63 | |
| GSE54994 | FTO | 79068 | 7 | 10 | 36 | |
| GSE60625 | FTO | 79068 | 4 | 0 | 7 | |
| GSE74703 | FTO | 79068 | 2 | 4 | 30 | |
| GSE74704 | FTO | 79068 | 3 | 0 | 17 | |
| TCGA | FTO | 79068 | 25 | 14 | 57 |
Total number of gains: 100; Total number of losses: 48; Total Number of normals: 340.
Somatic mutations of FTO:
Generating mutation plots.
Highly correlated genes for FTO:
Showing top 20/1038 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FTO | C19orf54 | 0.79326 | 4 | 0 | 4 |
| FTO | PPP1R35 | 0.788314 | 3 | 0 | 3 |
| FTO | TOP1MT | 0.770504 | 3 | 0 | 3 |
| FTO | ZNF503 | 0.766068 | 3 | 0 | 3 |
| FTO | PROX1 | 0.764853 | 3 | 0 | 3 |
| FTO | LSM2 | 0.749653 | 3 | 0 | 3 |
| FTO | DERL1 | 0.749483 | 3 | 0 | 3 |
| FTO | C7orf50 | 0.747043 | 4 | 0 | 4 |
| FTO | STRADA | 0.746045 | 3 | 0 | 3 |
| FTO | RILPL1 | 0.738068 | 3 | 0 | 3 |
| FTO | TMEM145 | 0.735692 | 3 | 0 | 3 |
| FTO | XPNPEP1 | 0.734913 | 3 | 0 | 3 |
| FTO | PKN3 | 0.731163 | 3 | 0 | 3 |
| FTO | CTU2 | 0.731076 | 3 | 0 | 3 |
| FTO | ZNF354A | 0.730648 | 3 | 0 | 3 |
| FTO | UCN | 0.72989 | 3 | 0 | 3 |
| FTO | SETD1A | 0.727912 | 4 | 0 | 4 |
| FTO | MRPL10 | 0.727341 | 4 | 0 | 3 |
| FTO | SLC36A1 | 0.726059 | 3 | 0 | 3 |
| FTO | LRRC14 | 0.721893 | 4 | 0 | 4 |
For details and further investigation, click here
