| Full name: regulator of G protein signaling 1 | Alias Symbol: 1R20|IR20|BL34 | ||
| Type: protein-coding gene | Cytoband: 1q31.2 | ||
| Entrez ID: 5996 | HGNC ID: HGNC:9991 | Ensembl Gene: ENSG00000090104 | OMIM ID: 600323 |
| Drug and gene relationship at DGIdb | |||
Expression of RGS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RGS1 | 5996 | 216834_at | 0.1758 | 0.7971 | |
| GSE20347 | RGS1 | 5996 | 216834_at | 0.2218 | 0.4629 | |
| GSE23400 | RGS1 | 5996 | 216834_at | 0.4826 | 0.0035 | |
| GSE26886 | RGS1 | 5996 | 216834_at | 2.7913 | 0.0001 | |
| GSE29001 | RGS1 | 5996 | 216834_at | 0.2582 | 0.4254 | |
| GSE38129 | RGS1 | 5996 | 216834_at | 0.3334 | 0.1877 | |
| GSE45670 | RGS1 | 5996 | 216834_at | -0.5963 | 0.1361 | |
| GSE53622 | RGS1 | 5996 | 108051 | 0.2233 | 0.1571 | |
| GSE53624 | RGS1 | 5996 | 108051 | 0.0889 | 0.5588 | |
| GSE63941 | RGS1 | 5996 | 202988_s_at | -0.0034 | 0.9826 | |
| GSE77861 | RGS1 | 5996 | 216834_at | 0.9585 | 0.1596 | |
| GSE97050 | RGS1 | 5996 | A_23_P97141 | 0.5957 | 0.1151 | |
| SRP007169 | RGS1 | 5996 | RNAseq | 0.3613 | 0.5773 | |
| SRP008496 | RGS1 | 5996 | RNAseq | 0.6226 | 0.2167 | |
| SRP064894 | RGS1 | 5996 | RNAseq | 0.6636 | 0.0523 | |
| SRP133303 | RGS1 | 5996 | RNAseq | 1.4997 | 0.0001 | |
| SRP159526 | RGS1 | 5996 | RNAseq | 0.7041 | 0.4571 | |
| SRP193095 | RGS1 | 5996 | RNAseq | 1.1991 | 0.0020 | |
| SRP219564 | RGS1 | 5996 | RNAseq | 1.4021 | 0.0039 | |
| TCGA | RGS1 | 5996 | RNAseq | 0.5658 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by RGS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RGS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RGS1 | 5996 | 8 | 1 | 21 | |
| GSE20123 | RGS1 | 5996 | 8 | 1 | 21 | |
| GSE43470 | RGS1 | 5996 | 5 | 1 | 37 | |
| GSE46452 | RGS1 | 5996 | 3 | 1 | 55 | |
| GSE47630 | RGS1 | 5996 | 14 | 0 | 26 | |
| GSE54993 | RGS1 | 5996 | 0 | 6 | 64 | |
| GSE54994 | RGS1 | 5996 | 15 | 0 | 38 | |
| GSE60625 | RGS1 | 5996 | 0 | 0 | 11 | |
| GSE74703 | RGS1 | 5996 | 5 | 1 | 30 | |
| GSE74704 | RGS1 | 5996 | 2 | 1 | 17 | |
| TCGA | RGS1 | 5996 | 43 | 4 | 49 |
Total number of gains: 103; Total number of losses: 16; Total Number of normals: 369.
Somatic mutations of RGS1:
Generating mutation plots.
Highly correlated genes for RGS1:
Showing top 20/588 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RGS1 | CHST12 | 0.808584 | 3 | 0 | 3 |
| RGS1 | CLEC11A | 0.77 | 3 | 0 | 3 |
| RGS1 | ELF4 | 0.768933 | 3 | 0 | 3 |
| RGS1 | A1BG | 0.764572 | 3 | 0 | 3 |
| RGS1 | SLC6A6 | 0.7624 | 3 | 0 | 3 |
| RGS1 | TIMM9 | 0.759805 | 3 | 0 | 3 |
| RGS1 | RRP15 | 0.755036 | 3 | 0 | 3 |
| RGS1 | MRPL9 | 0.748571 | 3 | 0 | 3 |
| RGS1 | LRRC58 | 0.74775 | 3 | 0 | 3 |
| RGS1 | GRAMD1A | 0.747459 | 3 | 0 | 3 |
| RGS1 | BRAT1 | 0.745246 | 3 | 0 | 3 |
| RGS1 | C12orf75 | 0.74315 | 3 | 0 | 3 |
| RGS1 | MED30 | 0.735748 | 3 | 0 | 3 |
| RGS1 | TRIM47 | 0.735547 | 3 | 0 | 3 |
| RGS1 | ACD | 0.735481 | 3 | 0 | 3 |
| RGS1 | CACYBP | 0.733043 | 4 | 0 | 4 |
| RGS1 | BCAS4 | 0.728631 | 3 | 0 | 3 |
| RGS1 | ZNF267 | 0.726362 | 3 | 0 | 3 |
| RGS1 | ALKBH6 | 0.725597 | 3 | 0 | 3 |
| RGS1 | LRRC14 | 0.725141 | 3 | 0 | 3 |
For details and further investigation, click here
