| Full name: tensin 3 | Alias Symbol: TEM6|H_NH0549I23.2|FLJ13732 | ||
| Type: protein-coding gene | Cytoband: 7p12.3 | ||
| Entrez ID: 64759 | HGNC ID: HGNC:21616 | Ensembl Gene: ENSG00000136205 | OMIM ID: 606825 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TNS3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNS3 | 64759 | 217853_at | 0.5684 | 0.2535 | |
| GSE20347 | TNS3 | 64759 | 217853_at | 0.9302 | 0.0007 | |
| GSE23400 | TNS3 | 64759 | 217853_at | 0.7932 | 0.0000 | |
| GSE26886 | TNS3 | 64759 | 217853_at | 1.8117 | 0.0002 | |
| GSE29001 | TNS3 | 64759 | 217853_at | 0.7036 | 0.0768 | |
| GSE38129 | TNS3 | 64759 | 217853_at | 0.4937 | 0.1274 | |
| GSE45670 | TNS3 | 64759 | 217853_at | 0.1393 | 0.7354 | |
| GSE53622 | TNS3 | 64759 | 2790 | 1.1290 | 0.0000 | |
| GSE53624 | TNS3 | 64759 | 2790 | 0.9799 | 0.0000 | |
| GSE63941 | TNS3 | 64759 | 217853_at | -1.5898 | 0.0466 | |
| GSE77861 | TNS3 | 64759 | 217853_at | 0.8687 | 0.2673 | |
| GSE97050 | TNS3 | 64759 | A_24_P346431 | 0.5270 | 0.1203 | |
| SRP007169 | TNS3 | 64759 | RNAseq | 2.6102 | 0.0001 | |
| SRP008496 | TNS3 | 64759 | RNAseq | 2.7503 | 0.0000 | |
| SRP064894 | TNS3 | 64759 | RNAseq | 1.3292 | 0.0000 | |
| SRP133303 | TNS3 | 64759 | RNAseq | 1.1089 | 0.0000 | |
| SRP159526 | TNS3 | 64759 | RNAseq | 0.9888 | 0.0278 | |
| SRP193095 | TNS3 | 64759 | RNAseq | 0.8143 | 0.0047 | |
| SRP219564 | TNS3 | 64759 | RNAseq | 0.7926 | 0.0801 | |
| TCGA | TNS3 | 64759 | RNAseq | -0.2962 | 0.0045 |
Upregulated datasets: 6; Downregulated datasets: 1.
Survival by TNS3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TNS3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNS3 | 64759 | 13 | 0 | 17 | |
| GSE20123 | TNS3 | 64759 | 13 | 0 | 17 | |
| GSE43470 | TNS3 | 64759 | 4 | 0 | 39 | |
| GSE46452 | TNS3 | 64759 | 11 | 1 | 47 | |
| GSE47630 | TNS3 | 64759 | 8 | 1 | 31 | |
| GSE54993 | TNS3 | 64759 | 0 | 8 | 62 | |
| GSE54994 | TNS3 | 64759 | 16 | 3 | 34 | |
| GSE60625 | TNS3 | 64759 | 0 | 0 | 11 | |
| GSE74703 | TNS3 | 64759 | 4 | 0 | 32 | |
| GSE74704 | TNS3 | 64759 | 7 | 0 | 13 | |
| TCGA | TNS3 | 64759 | 51 | 8 | 37 |
Total number of gains: 127; Total number of losses: 21; Total Number of normals: 340.
Somatic mutations of TNS3:
Generating mutation plots.
Highly correlated genes for TNS3:
Showing top 20/1435 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNS3 | FCGR3A | 0.784972 | 3 | 0 | 3 |
| TNS3 | KIAA1586 | 0.76336 | 4 | 0 | 4 |
| TNS3 | LMO1 | 0.760236 | 3 | 0 | 3 |
| TNS3 | KRTCAP2 | 0.757402 | 3 | 0 | 3 |
| TNS3 | FAM126A | 0.750282 | 3 | 0 | 3 |
| TNS3 | FAF2 | 0.739643 | 3 | 0 | 3 |
| TNS3 | LRRC8C | 0.736123 | 3 | 0 | 3 |
| TNS3 | ELP2 | 0.731933 | 3 | 0 | 3 |
| TNS3 | TMEM263 | 0.728809 | 7 | 0 | 7 |
| TNS3 | RILPL1 | 0.726542 | 3 | 0 | 3 |
| TNS3 | TNFRSF19 | 0.726322 | 3 | 0 | 3 |
| TNS3 | CEP170 | 0.725677 | 3 | 0 | 3 |
| TNS3 | FOXN3 | 0.723228 | 3 | 0 | 3 |
| TNS3 | LRRC14 | 0.722827 | 3 | 0 | 3 |
| TNS3 | CERKL | 0.721639 | 3 | 0 | 3 |
| TNS3 | GNG10 | 0.721073 | 3 | 0 | 3 |
| TNS3 | GXYLT2 | 0.721014 | 7 | 0 | 6 |
| TNS3 | CYB5D1 | 0.715604 | 3 | 0 | 3 |
| TNS3 | TMED8 | 0.715247 | 6 | 0 | 5 |
| TNS3 | TP53I13 | 0.713041 | 5 | 0 | 5 |
For details and further investigation, click here
