| Full name: semaphorin 3C | Alias Symbol: SemE | ||
| Type: protein-coding gene | Cytoband: 7q21.11 | ||
| Entrez ID: 10512 | HGNC ID: HGNC:10725 | Ensembl Gene: ENSG00000075223 | OMIM ID: 602645 |
| Drug and gene relationship at DGIdb | |||
SEMA3C involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of SEMA3C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEMA3C | 10512 | 203789_s_at | 0.9353 | 0.4549 | |
| GSE20347 | SEMA3C | 10512 | 203789_s_at | 2.1918 | 0.0002 | |
| GSE23400 | SEMA3C | 10512 | 203789_s_at | 1.0487 | 0.0000 | |
| GSE26886 | SEMA3C | 10512 | 203789_s_at | 4.6212 | 0.0000 | |
| GSE29001 | SEMA3C | 10512 | 203789_s_at | 1.6617 | 0.0042 | |
| GSE38129 | SEMA3C | 10512 | 203789_s_at | 1.3999 | 0.0087 | |
| GSE45670 | SEMA3C | 10512 | 203789_s_at | 0.3560 | 0.6588 | |
| GSE53622 | SEMA3C | 10512 | 58018 | 1.2823 | 0.0000 | |
| GSE53624 | SEMA3C | 10512 | 58018 | 1.4432 | 0.0000 | |
| GSE63941 | SEMA3C | 10512 | 203789_s_at | -1.8191 | 0.1988 | |
| GSE77861 | SEMA3C | 10512 | 203789_s_at | 2.8121 | 0.0037 | |
| GSE97050 | SEMA3C | 10512 | A_23_P256473 | 0.2772 | 0.4376 | |
| SRP007169 | SEMA3C | 10512 | RNAseq | 4.9733 | 0.0000 | |
| SRP008496 | SEMA3C | 10512 | RNAseq | 5.7171 | 0.0000 | |
| SRP064894 | SEMA3C | 10512 | RNAseq | 1.6630 | 0.0000 | |
| SRP133303 | SEMA3C | 10512 | RNAseq | 2.0447 | 0.0000 | |
| SRP159526 | SEMA3C | 10512 | RNAseq | 0.6266 | 0.0454 | |
| SRP193095 | SEMA3C | 10512 | RNAseq | 3.0533 | 0.0000 | |
| SRP219564 | SEMA3C | 10512 | RNAseq | 1.2695 | 0.1008 | |
| TCGA | SEMA3C | 10512 | RNAseq | -0.0677 | 0.5593 |
Upregulated datasets: 13; Downregulated datasets: 0.
Survival by SEMA3C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEMA3C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEMA3C | 10512 | 13 | 1 | 16 | |
| GSE20123 | SEMA3C | 10512 | 12 | 1 | 17 | |
| GSE43470 | SEMA3C | 10512 | 4 | 1 | 38 | |
| GSE46452 | SEMA3C | 10512 | 11 | 0 | 48 | |
| GSE47630 | SEMA3C | 10512 | 7 | 3 | 30 | |
| GSE54993 | SEMA3C | 10512 | 1 | 7 | 62 | |
| GSE54994 | SEMA3C | 10512 | 16 | 3 | 34 | |
| GSE60625 | SEMA3C | 10512 | 0 | 0 | 11 | |
| GSE74703 | SEMA3C | 10512 | 3 | 1 | 32 | |
| GSE74704 | SEMA3C | 10512 | 8 | 1 | 11 | |
| TCGA | SEMA3C | 10512 | 46 | 5 | 45 |
Total number of gains: 121; Total number of losses: 23; Total Number of normals: 344.
Somatic mutations of SEMA3C:
Generating mutation plots.
Highly correlated genes for SEMA3C:
Showing top 20/1518 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEMA3C | ALKBH6 | 0.850714 | 3 | 0 | 3 |
| SEMA3C | KRTCAP2 | 0.844678 | 3 | 0 | 3 |
| SEMA3C | KLHL13 | 0.843451 | 3 | 0 | 3 |
| SEMA3C | CRTC2 | 0.838146 | 3 | 0 | 3 |
| SEMA3C | METTL23 | 0.837625 | 3 | 0 | 3 |
| SEMA3C | CPT1A | 0.832892 | 3 | 0 | 3 |
| SEMA3C | PSMG3 | 0.820864 | 3 | 0 | 3 |
| SEMA3C | WDR81 | 0.81073 | 3 | 0 | 3 |
| SEMA3C | PPRC1 | 0.806986 | 3 | 0 | 3 |
| SEMA3C | ENAH | 0.798295 | 11 | 0 | 11 |
| SEMA3C | C19orf54 | 0.796349 | 3 | 0 | 3 |
| SEMA3C | LGALS8 | 0.79469 | 3 | 0 | 3 |
| SEMA3C | MSTO1 | 0.788745 | 3 | 0 | 3 |
| SEMA3C | SLC12A9 | 0.787513 | 3 | 0 | 3 |
| SEMA3C | MAP3K13 | 0.787372 | 3 | 0 | 3 |
| SEMA3C | GRAMD1A | 0.773432 | 4 | 0 | 4 |
| SEMA3C | POLR2J | 0.768291 | 3 | 0 | 3 |
| SEMA3C | FANCL | 0.767069 | 3 | 0 | 3 |
| SEMA3C | TRAF7 | 0.763387 | 3 | 0 | 3 |
| SEMA3C | LTBP1 | 0.761138 | 11 | 0 | 11 |
For details and further investigation, click here
