| Full name: insulin like growth factor binding protein 5 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q35 | ||
| Entrez ID: 3488 | HGNC ID: HGNC:5474 | Ensembl Gene: ENSG00000115461 | OMIM ID: 146734 |
| Drug and gene relationship at DGIdb | |||
Expression of IGFBP5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IGFBP5 | 3488 | 211959_at | -1.4985 | 0.1168 | |
| GSE20347 | IGFBP5 | 3488 | 211959_at | 0.3749 | 0.4052 | |
| GSE23400 | IGFBP5 | 3488 | 211959_at | -0.4630 | 0.0225 | |
| GSE26886 | IGFBP5 | 3488 | 211959_at | 0.4824 | 0.4905 | |
| GSE29001 | IGFBP5 | 3488 | 211959_at | -0.5870 | 0.3087 | |
| GSE38129 | IGFBP5 | 3488 | 211959_at | -0.0532 | 0.9095 | |
| GSE45670 | IGFBP5 | 3488 | 211959_at | -1.3431 | 0.0259 | |
| GSE53622 | IGFBP5 | 3488 | 65506 | -0.9508 | 0.0000 | |
| GSE53624 | IGFBP5 | 3488 | 65506 | -0.6084 | 0.0000 | |
| GSE63941 | IGFBP5 | 3488 | 211959_at | -7.9038 | 0.0002 | |
| GSE77861 | IGFBP5 | 3488 | 211959_at | 1.2834 | 0.0477 | |
| GSE97050 | IGFBP5 | 3488 | A_23_P383009 | -0.0963 | 0.8714 | |
| SRP007169 | IGFBP5 | 3488 | RNAseq | 2.5771 | 0.0000 | |
| SRP008496 | IGFBP5 | 3488 | RNAseq | 2.5218 | 0.0000 | |
| SRP064894 | IGFBP5 | 3488 | RNAseq | -0.1464 | 0.7272 | |
| SRP133303 | IGFBP5 | 3488 | RNAseq | -0.8248 | 0.0005 | |
| SRP193095 | IGFBP5 | 3488 | RNAseq | 1.3982 | 0.0001 | |
| SRP219564 | IGFBP5 | 3488 | RNAseq | 0.4353 | 0.6008 | |
| TCGA | IGFBP5 | 3488 | RNAseq | -0.4713 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 2.
Survival by IGFBP5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IGFBP5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IGFBP5 | 3488 | 1 | 13 | 16 | |
| GSE20123 | IGFBP5 | 3488 | 1 | 13 | 16 | |
| GSE43470 | IGFBP5 | 3488 | 0 | 7 | 36 | |
| GSE46452 | IGFBP5 | 3488 | 0 | 5 | 54 | |
| GSE47630 | IGFBP5 | 3488 | 4 | 5 | 31 | |
| GSE54993 | IGFBP5 | 3488 | 0 | 3 | 67 | |
| GSE54994 | IGFBP5 | 3488 | 8 | 9 | 36 | |
| GSE60625 | IGFBP5 | 3488 | 0 | 3 | 8 | |
| GSE74703 | IGFBP5 | 3488 | 0 | 6 | 30 | |
| GSE74704 | IGFBP5 | 3488 | 1 | 7 | 12 | |
| TCGA | IGFBP5 | 3488 | 11 | 27 | 58 |
Total number of gains: 26; Total number of losses: 98; Total Number of normals: 364.
Somatic mutations of IGFBP5:
Generating mutation plots.
Highly correlated genes for IGFBP5:
Showing top 20/718 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IGFBP5 | SMURF2 | 0.795788 | 3 | 0 | 3 |
| IGFBP5 | SNX25 | 0.793039 | 3 | 0 | 3 |
| IGFBP5 | C11orf96 | 0.769623 | 4 | 0 | 4 |
| IGFBP5 | KPNA5 | 0.765221 | 3 | 0 | 3 |
| IGFBP5 | HNRNPUL2 | 0.760681 | 3 | 0 | 3 |
| IGFBP5 | FNIP2 | 0.756222 | 3 | 0 | 3 |
| IGFBP5 | PPP3CC | 0.755521 | 3 | 0 | 3 |
| IGFBP5 | LTBP2 | 0.749449 | 3 | 0 | 3 |
| IGFBP5 | CXCL5 | 0.742822 | 3 | 0 | 3 |
| IGFBP5 | LTBP1 | 0.735694 | 4 | 0 | 4 |
| IGFBP5 | GLIPR1 | 0.733654 | 3 | 0 | 3 |
| IGFBP5 | TSHZ3 | 0.72513 | 3 | 0 | 3 |
| IGFBP5 | NR2F1 | 0.724924 | 3 | 0 | 3 |
| IGFBP5 | APH1B | 0.719213 | 3 | 0 | 3 |
| IGFBP5 | GIMAP8 | 0.718056 | 5 | 0 | 5 |
| IGFBP5 | IQCE | 0.712913 | 3 | 0 | 3 |
| IGFBP5 | PRPH2 | 0.709766 | 4 | 0 | 3 |
| IGFBP5 | INO80D | 0.709623 | 3 | 0 | 3 |
| IGFBP5 | FEZ1 | 0.708411 | 3 | 0 | 3 |
| IGFBP5 | C9orf72 | 0.705684 | 3 | 0 | 3 |
For details and further investigation, click here
