| Full name: lymphocyte antigen 6 family member D | Alias Symbol: E48 | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 8581 | HGNC ID: HGNC:13348 | Ensembl Gene: ENSG00000167656 | OMIM ID: 606204 |
| Drug and gene relationship at DGIdb | |||
Expression of LY6D:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LY6D | 8581 | 206276_at | -0.5857 | 0.6064 | |
| GSE20347 | LY6D | 8581 | 206276_at | -1.8621 | 0.0009 | |
| GSE23400 | LY6D | 8581 | 206276_at | -1.0344 | 0.0003 | |
| GSE26886 | LY6D | 8581 | 206276_at | -2.2481 | 0.0013 | |
| GSE29001 | LY6D | 8581 | 206276_at | -2.4429 | 0.0085 | |
| GSE38129 | LY6D | 8581 | 206276_at | -0.8877 | 0.3087 | |
| GSE45670 | LY6D | 8581 | 206276_at | -0.0731 | 0.8830 | |
| GSE53622 | LY6D | 8581 | 46587 | -1.2677 | 0.0002 | |
| GSE53624 | LY6D | 8581 | 46587 | -1.7058 | 0.0000 | |
| GSE63941 | LY6D | 8581 | 206276_at | 2.8601 | 0.2101 | |
| GSE77861 | LY6D | 8581 | 206276_at | -1.3676 | 0.0363 | |
| GSE97050 | LY6D | 8581 | A_33_P3268622 | -0.3242 | 0.8218 | |
| SRP007169 | LY6D | 8581 | RNAseq | -3.1913 | 0.0012 | |
| SRP008496 | LY6D | 8581 | RNAseq | -3.6983 | 0.0000 | |
| SRP064894 | LY6D | 8581 | RNAseq | -2.2935 | 0.0000 | |
| SRP133303 | LY6D | 8581 | RNAseq | -1.5424 | 0.0026 | |
| SRP159526 | LY6D | 8581 | RNAseq | -3.7715 | 0.0000 | |
| SRP219564 | LY6D | 8581 | RNAseq | -1.6666 | 0.2365 | |
| TCGA | LY6D | 8581 | RNAseq | 1.2956 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 12.
Survival by LY6D expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LY6D:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LY6D | 8581 | 16 | 1 | 13 | |
| GSE20123 | LY6D | 8581 | 17 | 1 | 12 | |
| GSE43470 | LY6D | 8581 | 17 | 2 | 24 | |
| GSE46452 | LY6D | 8581 | 27 | 0 | 32 | |
| GSE47630 | LY6D | 8581 | 23 | 1 | 16 | |
| GSE54993 | LY6D | 8581 | 0 | 25 | 45 | |
| GSE54994 | LY6D | 8581 | 39 | 1 | 13 | |
| GSE60625 | LY6D | 8581 | 3 | 4 | 4 | |
| GSE74703 | LY6D | 8581 | 15 | 1 | 20 | |
| GSE74704 | LY6D | 8581 | 10 | 0 | 10 | |
| TCGA | LY6D | 8581 | 63 | 2 | 31 |
Total number of gains: 230; Total number of losses: 38; Total Number of normals: 220.
Somatic mutations of LY6D:
Generating mutation plots.
Highly correlated genes for LY6D:
Showing top 20/786 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LY6D | PGLYRP3 | 0.787145 | 3 | 0 | 3 |
| LY6D | KRT83 | 0.768162 | 3 | 0 | 3 |
| LY6D | AQP3 | 0.723067 | 13 | 0 | 13 |
| LY6D | RPS25 | 0.704212 | 3 | 0 | 3 |
| LY6D | RHOV | 0.700516 | 8 | 0 | 7 |
| LY6D | EVPL | 0.698802 | 10 | 0 | 10 |
| LY6D | EPHX3 | 0.695487 | 10 | 0 | 9 |
| LY6D | KRT13 | 0.694431 | 11 | 0 | 10 |
| LY6D | COMMD9 | 0.693071 | 3 | 0 | 3 |
| LY6D | CAPNS2 | 0.692304 | 4 | 0 | 4 |
| LY6D | TMPRSS11D | 0.691757 | 11 | 0 | 9 |
| LY6D | ANKRD24 | 0.691206 | 4 | 0 | 4 |
| LY6D | KRT6C | 0.688161 | 4 | 0 | 4 |
| LY6D | GLTP | 0.68783 | 7 | 0 | 6 |
| LY6D | TRIM29 | 0.683594 | 12 | 0 | 11 |
| LY6D | TMEM79 | 0.682948 | 8 | 0 | 7 |
| LY6D | CTNND1 | 0.678865 | 3 | 0 | 3 |
| LY6D | OTOP3 | 0.674147 | 3 | 0 | 3 |
| LY6D | GPR45 | 0.673917 | 4 | 0 | 3 |
| LY6D | MPZL2 | 0.673488 | 13 | 0 | 11 |
For details and further investigation, click here
