| Full name: keratin 6C | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 286887 | HGNC ID: HGNC:20406 | Ensembl Gene: ENSG00000170465 | OMIM ID: 612315 |
| Drug and gene relationship at DGIdb | |||
Expression of KRT6C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | KRT6C | 286887 | 120662 | -0.6816 | 0.0398 | |
| GSE53624 | KRT6C | 286887 | 120662 | -1.1013 | 0.0000 | |
| GSE97050 | KRT6C | 286887 | A_23_P366936 | 1.5607 | 0.2492 | |
| SRP007169 | KRT6C | 286887 | RNAseq | -6.2766 | 0.0000 | |
| SRP008496 | KRT6C | 286887 | RNAseq | -3.8141 | 0.0000 | |
| SRP064894 | KRT6C | 286887 | RNAseq | -1.5155 | 0.0162 | |
| SRP133303 | KRT6C | 286887 | RNAseq | -1.8420 | 0.0276 | |
| SRP219564 | KRT6C | 286887 | RNAseq | -2.6498 | 0.0718 | |
| TCGA | KRT6C | 286887 | RNAseq | 1.0465 | 0.0006 |
Upregulated datasets: 1; Downregulated datasets: 5.
Survival by KRT6C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KRT6C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KRT6C | 286887 | 8 | 1 | 21 | |
| GSE20123 | KRT6C | 286887 | 8 | 1 | 21 | |
| GSE43470 | KRT6C | 286887 | 3 | 0 | 40 | |
| GSE46452 | KRT6C | 286887 | 7 | 1 | 51 | |
| GSE47630 | KRT6C | 286887 | 10 | 2 | 28 | |
| GSE54993 | KRT6C | 286887 | 0 | 5 | 65 | |
| GSE54994 | KRT6C | 286887 | 5 | 1 | 47 | |
| GSE60625 | KRT6C | 286887 | 0 | 0 | 11 | |
| GSE74703 | KRT6C | 286887 | 3 | 0 | 33 | |
| GSE74704 | KRT6C | 286887 | 5 | 1 | 14 | |
| TCGA | KRT6C | 286887 | 13 | 11 | 72 |
Total number of gains: 62; Total number of losses: 23; Total Number of normals: 403.
Somatic mutations of KRT6C:
Generating mutation plots.
Highly correlated genes for KRT6C:
Showing top 20/254 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KRT6C | KRT5 | 0.844284 | 4 | 0 | 4 |
| KRT6C | KRT6B | 0.826471 | 4 | 0 | 4 |
| KRT6C | KRT16 | 0.820809 | 4 | 0 | 4 |
| KRT6C | KRT6A | 0.819276 | 4 | 0 | 4 |
| KRT6C | DSG3 | 0.802979 | 4 | 0 | 4 |
| KRT6C | KRT75 | 0.802363 | 4 | 0 | 3 |
| KRT6C | DSC2 | 0.801364 | 4 | 0 | 4 |
| KRT6C | KRT83 | 0.801131 | 3 | 0 | 3 |
| KRT6C | GNA15 | 0.796602 | 4 | 0 | 4 |
| KRT6C | SPRR1B | 0.789975 | 4 | 0 | 4 |
| KRT6C | LYPD3 | 0.784918 | 4 | 0 | 4 |
| KRT6C | PKP1 | 0.782223 | 4 | 0 | 4 |
| KRT6C | PERP | 0.770313 | 4 | 0 | 4 |
| KRT6C | SERPINB5 | 0.766086 | 4 | 0 | 4 |
| KRT6C | GPR45 | 0.764032 | 3 | 0 | 3 |
| KRT6C | DSP | 0.761705 | 4 | 0 | 4 |
| KRT6C | KLK8 | 0.756794 | 4 | 0 | 4 |
| KRT6C | ZBED2 | 0.755212 | 3 | 0 | 3 |
| KRT6C | SH3RF2 | 0.754462 | 3 | 0 | 3 |
| KRT6C | SBSN | 0.751141 | 4 | 0 | 4 |
For details and further investigation, click here
