CTNND1

 

Full name: catenin delta 1 Alias Symbol: KIAA0384|p120|p120cas|p120ctn
Type: protein-coding gene Cytoband: 11q12.1
Entrez ID: 1500 HGNC ID: HGNC:2515 Ensembl Gene: ENSG00000198561 OMIM ID: 601045
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

CTNND1 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04520Adherens junction
hsa04670Leukocyte transendothelial migration

 

Expression of CTNND1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE53622 CTNND1 1500 128421 -0.5951 0.0000
GSE53624 CTNND1 1500 128421 -0.6512 0.0000
GSE97050 CTNND1 1500 A_33_P3209716 -0.0152 0.9760
SRP007169 CTNND1 1500 RNAseq -0.2267 0.5351
SRP008496 CTNND1 1500 RNAseq -0.5118 0.0263
SRP064894 CTNND1 1500 RNAseq -1.2639 0.0000
SRP133303 CTNND1 1500 RNAseq -0.5573 0.0080
SRP159526 CTNND1 1500 RNAseq -0.8468 0.0005
SRP193095 CTNND1 1500 RNAseq -0.9399 0.0000
SRP219564 CTNND1 1500 RNAseq -1.1642 0.0404
TCGA CTNND1 1500 RNAseq -0.0026 0.9554

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by CTNND1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CTNND1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CTNND1 1500 2 3 25
GSE20123 CTNND1 1500 2 3 25
GSE43470 CTNND1 1500 1 5 37
GSE46452 CTNND1 1500 9 4 46
GSE47630 CTNND1 1500 3 8 29
GSE54993 CTNND1 1500 3 0 67
GSE54994 CTNND1 1500 5 6 42
GSE60625 CTNND1 1500 0 3 8
GSE74703 CTNND1 1500 1 3 32
GSE74704 CTNND1 1500 2 3 15
TCGA CTNND1 1500 14 10 72

Total number of gains: 42; Total number of losses: 48; Total Number of normals: 398.  

 

Somatic mutations of CTNND1:

 

Generating mutation plots.

 

Highly correlated genes for CTNND1:

 

Showing top 20/323 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CTNND1ARHGAP320.829739303
CTNND1FAM135A0.803424303
CTNND1GRHL10.79218303
CTNND1MPZL20.791248303
CTNND1CAPN10.790572303
CTNND1S100A160.776598303
CTNND1ZDHHC130.76285303
CTNND1FAM160A10.762313303
CTNND1ARHGAP270.757153303
CTNND1DSG30.756219303
CTNND1TMEM400.755972303
CTNND1TGM10.755856303
CTNND1S100A140.755671303
CTNND1SERPINB10.751325303
CTNND1BTBD110.751007303
CTNND1NIPAL10.750687303
CTNND1EHF0.75052303
CTNND1RAB27B0.750442303
CTNND1ZNF7500.748762303
CTNND1PGLYRP30.748002303

For details and further investigation, click here