| Full name: G protein-coupled receptor 45 | Alias Symbol: PSP24|PSP24A | ||
| Type: protein-coding gene | Cytoband: 2q12.1 | ||
| Entrez ID: 11250 | HGNC ID: HGNC:4503 | Ensembl Gene: ENSG00000135973 | OMIM ID: 604838 |
| Drug and gene relationship at DGIdb | |||
Expression of GPR45:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPR45 | 11250 | 211175_at | 0.0466 | 0.8392 | |
| GSE20347 | GPR45 | 11250 | 211175_at | -0.0581 | 0.4276 | |
| GSE23400 | GPR45 | 11250 | 211175_at | -0.0693 | 0.0114 | |
| GSE26886 | GPR45 | 11250 | 211175_at | -0.1123 | 0.3256 | |
| GSE29001 | GPR45 | 11250 | 211175_at | -0.1085 | 0.2832 | |
| GSE38129 | GPR45 | 11250 | 211175_at | -0.1264 | 0.0097 | |
| GSE45670 | GPR45 | 11250 | 211175_at | 0.0540 | 0.5345 | |
| GSE53622 | GPR45 | 11250 | 4695 | -1.6275 | 0.0000 | |
| GSE53624 | GPR45 | 11250 | 4695 | -2.4691 | 0.0000 | |
| GSE63941 | GPR45 | 11250 | 211175_at | 0.1079 | 0.4408 | |
| GSE77861 | GPR45 | 11250 | 211175_at | -0.2774 | 0.0660 | |
| GSE97050 | GPR45 | 11250 | A_23_P131534 | 0.0626 | 0.8626 | |
| TCGA | GPR45 | 11250 | RNAseq | -0.7489 | 0.2964 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by GPR45 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPR45:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPR45 | 11250 | 3 | 2 | 25 | |
| GSE20123 | GPR45 | 11250 | 3 | 2 | 25 | |
| GSE43470 | GPR45 | 11250 | 3 | 1 | 39 | |
| GSE46452 | GPR45 | 11250 | 1 | 4 | 54 | |
| GSE47630 | GPR45 | 11250 | 7 | 0 | 33 | |
| GSE54993 | GPR45 | 11250 | 0 | 6 | 64 | |
| GSE54994 | GPR45 | 11250 | 10 | 0 | 43 | |
| GSE60625 | GPR45 | 11250 | 0 | 3 | 8 | |
| GSE74703 | GPR45 | 11250 | 3 | 1 | 32 | |
| GSE74704 | GPR45 | 11250 | 2 | 2 | 16 | |
| TCGA | GPR45 | 11250 | 34 | 5 | 57 |
Total number of gains: 66; Total number of losses: 26; Total Number of normals: 396.
Somatic mutations of GPR45:
Generating mutation plots.
Highly correlated genes for GPR45:
Showing top 20/665 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPR45 | SPRR2D | 0.931978 | 3 | 0 | 3 |
| GPR45 | SPRR2E | 0.930331 | 3 | 0 | 3 |
| GPR45 | SPRR2F | 0.925062 | 3 | 0 | 3 |
| GPR45 | SPRR2A | 0.916617 | 3 | 0 | 3 |
| GPR45 | SPRR2B | 0.865281 | 3 | 0 | 3 |
| GPR45 | NCCRP1 | 0.817921 | 3 | 0 | 3 |
| GPR45 | GJB6 | 0.80232 | 3 | 0 | 3 |
| GPR45 | TMPRSS11A | 0.799258 | 3 | 0 | 3 |
| GPR45 | OTOP3 | 0.769801 | 3 | 0 | 3 |
| GPR45 | CYSRT1 | 0.768715 | 3 | 0 | 3 |
| GPR45 | KRT6C | 0.764032 | 3 | 0 | 3 |
| GPR45 | PGLYRP3 | 0.758542 | 4 | 0 | 3 |
| GPR45 | VSIG10L | 0.754463 | 4 | 0 | 4 |
| GPR45 | RNF222 | 0.752051 | 3 | 0 | 3 |
| GPR45 | KRTAP20-3 | 0.751802 | 3 | 0 | 3 |
| GPR45 | SDCBP2 | 0.739614 | 3 | 0 | 3 |
| GPR45 | KPRP | 0.733725 | 3 | 0 | 3 |
| GPR45 | TMEM45B | 0.731115 | 4 | 0 | 4 |
| GPR45 | IL20RB | 0.717266 | 4 | 0 | 3 |
| GPR45 | HS3ST6 | 0.716145 | 4 | 0 | 4 |
For details and further investigation, click here
