| Full name: epoxide hydrolase 3 | Alias Symbol: FLJ22408 | ||
| Type: protein-coding gene | Cytoband: 19p13.12 | ||
| Entrez ID: 79852 | HGNC ID: HGNC:23760 | Ensembl Gene: ENSG00000105131 | OMIM ID: 617400 |
| Drug and gene relationship at DGIdb | |||
Expression of EPHX3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EPHX3 | 79852 | 220013_at | -1.2113 | 0.3298 | |
| GSE20347 | EPHX3 | 79852 | 220013_at | -2.7871 | 0.0000 | |
| GSE23400 | EPHX3 | 79852 | 220013_at | -1.6876 | 0.0000 | |
| GSE26886 | EPHX3 | 79852 | 220013_at | -2.7345 | 0.0000 | |
| GSE29001 | EPHX3 | 79852 | 220013_at | -1.7714 | 0.0007 | |
| GSE38129 | EPHX3 | 79852 | 220013_at | -2.1193 | 0.0002 | |
| GSE45670 | EPHX3 | 79852 | 220013_at | -0.6909 | 0.2792 | |
| GSE53622 | EPHX3 | 79852 | 11027 | -1.2504 | 0.0000 | |
| GSE53624 | EPHX3 | 79852 | 11027 | -2.2909 | 0.0000 | |
| GSE63941 | EPHX3 | 79852 | 220013_at | 0.0153 | 0.9470 | |
| GSE77861 | EPHX3 | 79852 | 220013_at | -1.7028 | 0.0206 | |
| GSE97050 | EPHX3 | 79852 | A_23_P119593 | -0.2283 | 0.4399 | |
| SRP007169 | EPHX3 | 79852 | RNAseq | -3.0789 | 0.0000 | |
| SRP008496 | EPHX3 | 79852 | RNAseq | -3.1663 | 0.0000 | |
| SRP064894 | EPHX3 | 79852 | RNAseq | -3.3589 | 0.0000 | |
| SRP133303 | EPHX3 | 79852 | RNAseq | -2.5052 | 0.0000 | |
| SRP159526 | EPHX3 | 79852 | RNAseq | -2.4001 | 0.0047 | |
| SRP219564 | EPHX3 | 79852 | RNAseq | -3.8921 | 0.0004 | |
| TCGA | EPHX3 | 79852 | RNAseq | 0.8508 | 0.0186 |
Upregulated datasets: 0; Downregulated datasets: 14.
Survival by EPHX3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EPHX3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EPHX3 | 79852 | 4 | 2 | 24 | |
| GSE20123 | EPHX3 | 79852 | 3 | 1 | 26 | |
| GSE43470 | EPHX3 | 79852 | 2 | 6 | 35 | |
| GSE46452 | EPHX3 | 79852 | 47 | 1 | 11 | |
| GSE47630 | EPHX3 | 79852 | 4 | 7 | 29 | |
| GSE54993 | EPHX3 | 79852 | 15 | 4 | 51 | |
| GSE54994 | EPHX3 | 79852 | 6 | 13 | 34 | |
| GSE60625 | EPHX3 | 79852 | 9 | 0 | 2 | |
| GSE74703 | EPHX3 | 79852 | 2 | 4 | 30 | |
| GSE74704 | EPHX3 | 79852 | 0 | 1 | 19 | |
| TCGA | EPHX3 | 79852 | 21 | 10 | 65 |
Total number of gains: 113; Total number of losses: 49; Total Number of normals: 326.
Somatic mutations of EPHX3:
Generating mutation plots.
Highly correlated genes for EPHX3:
Showing top 20/1586 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EPHX3 | NCCRP1 | 0.858049 | 3 | 0 | 3 |
| EPHX3 | CLIC3 | 0.83972 | 9 | 0 | 9 |
| EPHX3 | SPRR2D | 0.826157 | 3 | 0 | 3 |
| EPHX3 | EVPL | 0.821153 | 11 | 0 | 11 |
| EPHX3 | SMAGP | 0.817416 | 11 | 0 | 11 |
| EPHX3 | PRSS27 | 0.817153 | 7 | 0 | 7 |
| EPHX3 | FAM3D | 0.81658 | 7 | 0 | 7 |
| EPHX3 | KLK13 | 0.814388 | 11 | 0 | 11 |
| EPHX3 | SPRR2E | 0.813112 | 3 | 0 | 3 |
| EPHX3 | SPRR2F | 0.811763 | 3 | 0 | 3 |
| EPHX3 | IL1RN | 0.811534 | 11 | 0 | 11 |
| EPHX3 | ACPP | 0.803869 | 11 | 0 | 11 |
| EPHX3 | CYSRT1 | 0.803079 | 6 | 0 | 6 |
| EPHX3 | CSTB | 0.802625 | 11 | 0 | 11 |
| EPHX3 | PITX1 | 0.80196 | 11 | 0 | 11 |
| EPHX3 | PPL | 0.801511 | 11 | 0 | 11 |
| EPHX3 | EPS8L1 | 0.801508 | 11 | 0 | 11 |
| EPHX3 | GDPD3 | 0.800892 | 11 | 0 | 11 |
| EPHX3 | GRHL1 | 0.800339 | 7 | 0 | 7 |
| EPHX3 | SPRR2A | 0.79931 | 3 | 0 | 3 |
For details and further investigation, click here
