| Full name: leucine zipper like transcription regulator 1 | Alias Symbol: LZTR-1|BTBD29 | ||
| Type: protein-coding gene | Cytoband: 22q11.21 | ||
| Entrez ID: 8216 | HGNC ID: HGNC:6742 | Ensembl Gene: ENSG00000099949 | OMIM ID: 600574 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of LZTR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LZTR1 | 8216 | 203412_at | 0.2613 | 0.3331 | |
| GSE20347 | LZTR1 | 8216 | 203412_at | 0.2043 | 0.0399 | |
| GSE23400 | LZTR1 | 8216 | 203412_at | 0.2213 | 0.0000 | |
| GSE26886 | LZTR1 | 8216 | 203412_at | 0.5648 | 0.0000 | |
| GSE29001 | LZTR1 | 8216 | 203412_at | 0.1320 | 0.6064 | |
| GSE38129 | LZTR1 | 8216 | 203412_at | 0.1533 | 0.2445 | |
| GSE45670 | LZTR1 | 8216 | 203412_at | 0.4536 | 0.0843 | |
| GSE53622 | LZTR1 | 8216 | 77515 | 0.1647 | 0.1229 | |
| GSE53624 | LZTR1 | 8216 | 77515 | 0.4289 | 0.0000 | |
| GSE63941 | LZTR1 | 8216 | 203412_at | -0.3211 | 0.3661 | |
| GSE77861 | LZTR1 | 8216 | 203412_at | 0.3491 | 0.0284 | |
| GSE97050 | LZTR1 | 8216 | A_23_P57401 | -0.0822 | 0.7123 | |
| SRP007169 | LZTR1 | 8216 | RNAseq | 0.9996 | 0.0077 | |
| SRP008496 | LZTR1 | 8216 | RNAseq | 1.1813 | 0.0000 | |
| SRP064894 | LZTR1 | 8216 | RNAseq | 0.9136 | 0.0000 | |
| SRP133303 | LZTR1 | 8216 | RNAseq | 0.2272 | 0.1058 | |
| SRP159526 | LZTR1 | 8216 | RNAseq | 0.3026 | 0.3406 | |
| SRP193095 | LZTR1 | 8216 | RNAseq | 0.6328 | 0.0000 | |
| SRP219564 | LZTR1 | 8216 | RNAseq | 0.4650 | 0.0566 | |
| TCGA | LZTR1 | 8216 | RNAseq | 0.0374 | 0.4828 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by LZTR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LZTR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LZTR1 | 8216 | 6 | 7 | 17 | |
| GSE20123 | LZTR1 | 8216 | 6 | 7 | 17 | |
| GSE43470 | LZTR1 | 8216 | 3 | 7 | 33 | |
| GSE46452 | LZTR1 | 8216 | 33 | 1 | 25 | |
| GSE47630 | LZTR1 | 8216 | 8 | 5 | 27 | |
| GSE54993 | LZTR1 | 8216 | 3 | 6 | 61 | |
| GSE54994 | LZTR1 | 8216 | 11 | 7 | 35 | |
| GSE60625 | LZTR1 | 8216 | 5 | 0 | 6 | |
| GSE74703 | LZTR1 | 8216 | 3 | 5 | 28 | |
| GSE74704 | LZTR1 | 8216 | 3 | 4 | 13 | |
| TCGA | LZTR1 | 8216 | 27 | 17 | 52 |
Total number of gains: 108; Total number of losses: 66; Total Number of normals: 314.
Somatic mutations of LZTR1:
Generating mutation plots.
Highly correlated genes for LZTR1:
Showing top 20/686 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LZTR1 | FILIP1 | 0.80527 | 3 | 0 | 3 |
| LZTR1 | RILPL1 | 0.712134 | 5 | 0 | 4 |
| LZTR1 | SNAPC2 | 0.698794 | 5 | 0 | 5 |
| LZTR1 | PDE3A | 0.693255 | 3 | 0 | 3 |
| LZTR1 | CCDC9 | 0.68338 | 4 | 0 | 3 |
| LZTR1 | AP2A1 | 0.673406 | 3 | 0 | 3 |
| LZTR1 | PBXIP1 | 0.665926 | 5 | 0 | 5 |
| LZTR1 | HMCN1 | 0.664065 | 4 | 0 | 4 |
| LZTR1 | S1PR3 | 0.663631 | 4 | 0 | 4 |
| LZTR1 | TGFB1I1 | 0.663389 | 5 | 0 | 4 |
| LZTR1 | CAND2 | 0.662291 | 3 | 0 | 3 |
| LZTR1 | DOCK11 | 0.661888 | 3 | 0 | 3 |
| LZTR1 | TMEM161A | 0.654817 | 7 | 0 | 5 |
| LZTR1 | RGS2 | 0.652091 | 3 | 0 | 3 |
| LZTR1 | FGF2 | 0.651217 | 4 | 0 | 3 |
| LZTR1 | TSPYL2 | 0.647916 | 5 | 0 | 4 |
| LZTR1 | POGZ | 0.646925 | 3 | 0 | 3 |
| LZTR1 | SLC39A3 | 0.646091 | 4 | 0 | 4 |
| LZTR1 | STK32B | 0.643594 | 4 | 0 | 3 |
| LZTR1 | PLEKHO1 | 0.643406 | 5 | 0 | 4 |
For details and further investigation, click here
