| Full name: regulator of G protein signaling 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q31.2 | ||
| Entrez ID: 5997 | HGNC ID: HGNC:9998 | Ensembl Gene: ENSG00000116741 | OMIM ID: 600861 |
| Drug and gene relationship at DGIdb | |||
RGS2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04022 | cGMP-PKG signaling pathway | |
| hsa04740 | Olfactory transduction | |
| hsa04921 | Oxytocin signaling pathway |
Expression of RGS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RGS2 | 5997 | 202388_at | -1.2915 | 0.1372 | |
| GSE20347 | RGS2 | 5997 | 202388_at | -0.2923 | 0.5318 | |
| GSE23400 | RGS2 | 5997 | 202388_at | -0.3076 | 0.1720 | |
| GSE26886 | RGS2 | 5997 | 202388_at | 1.3795 | 0.0079 | |
| GSE29001 | RGS2 | 5997 | 202388_at | -0.2187 | 0.6067 | |
| GSE38129 | RGS2 | 5997 | 202388_at | -0.6745 | 0.0840 | |
| GSE45670 | RGS2 | 5997 | 202388_at | -1.4897 | 0.0005 | |
| GSE53622 | RGS2 | 5997 | 12295 | -0.8553 | 0.0000 | |
| GSE53624 | RGS2 | 5997 | 12295 | -0.8249 | 0.0000 | |
| GSE63941 | RGS2 | 5997 | 202388_at | -2.9495 | 0.0246 | |
| GSE77861 | RGS2 | 5997 | 202388_at | 0.7302 | 0.2195 | |
| GSE97050 | RGS2 | 5997 | A_23_P114947 | -0.8151 | 0.1939 | |
| SRP007169 | RGS2 | 5997 | RNAseq | -0.0946 | 0.8349 | |
| SRP008496 | RGS2 | 5997 | RNAseq | 0.4652 | 0.1919 | |
| SRP064894 | RGS2 | 5997 | RNAseq | -0.0852 | 0.8430 | |
| SRP133303 | RGS2 | 5997 | RNAseq | 0.1827 | 0.7268 | |
| SRP159526 | RGS2 | 5997 | RNAseq | -0.0577 | 0.9363 | |
| SRP193095 | RGS2 | 5997 | RNAseq | 0.0468 | 0.9076 | |
| SRP219564 | RGS2 | 5997 | RNAseq | -0.4571 | 0.6418 | |
| TCGA | RGS2 | 5997 | RNAseq | -0.4463 | 0.0003 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by RGS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RGS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RGS2 | 5997 | 9 | 1 | 20 | |
| GSE20123 | RGS2 | 5997 | 9 | 1 | 20 | |
| GSE43470 | RGS2 | 5997 | 5 | 1 | 37 | |
| GSE46452 | RGS2 | 5997 | 3 | 1 | 55 | |
| GSE47630 | RGS2 | 5997 | 14 | 0 | 26 | |
| GSE54993 | RGS2 | 5997 | 0 | 6 | 64 | |
| GSE54994 | RGS2 | 5997 | 15 | 0 | 38 | |
| GSE60625 | RGS2 | 5997 | 0 | 0 | 11 | |
| GSE74703 | RGS2 | 5997 | 5 | 1 | 30 | |
| GSE74704 | RGS2 | 5997 | 3 | 1 | 16 | |
| TCGA | RGS2 | 5997 | 41 | 5 | 50 |
Total number of gains: 104; Total number of losses: 17; Total Number of normals: 367.
Somatic mutations of RGS2:
Generating mutation plots.
Highly correlated genes for RGS2:
Showing top 20/852 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RGS2 | LRFN5 | 0.76627 | 4 | 0 | 4 |
| RGS2 | ANO5 | 0.758282 | 5 | 0 | 5 |
| RGS2 | XKR4 | 0.757606 | 5 | 0 | 5 |
| RGS2 | AOC3 | 0.737491 | 11 | 0 | 10 |
| RGS2 | FILIP1 | 0.736683 | 6 | 0 | 6 |
| RGS2 | MYADM | 0.736088 | 4 | 0 | 4 |
| RGS2 | C11orf96 | 0.731794 | 5 | 0 | 5 |
| RGS2 | PPP1R12B | 0.731195 | 10 | 0 | 9 |
| RGS2 | PARD3B | 0.730039 | 5 | 0 | 5 |
| RGS2 | ZEB1 | 0.726937 | 3 | 0 | 3 |
| RGS2 | RBPMS2 | 0.726678 | 8 | 0 | 8 |
| RGS2 | ACTBL2 | 0.722804 | 3 | 0 | 3 |
| RGS2 | CYP21A2 | 0.719688 | 3 | 0 | 3 |
| RGS2 | ZNF512 | 0.719561 | 3 | 0 | 3 |
| RGS2 | IQUB | 0.716317 | 3 | 0 | 3 |
| RGS2 | CACNB2 | 0.715691 | 8 | 0 | 7 |
| RGS2 | TCEAL6 | 0.71548 | 3 | 0 | 3 |
| RGS2 | TAGLN | 0.714948 | 11 | 0 | 11 |
| RGS2 | FLNC | 0.711353 | 12 | 0 | 11 |
| RGS2 | PGR | 0.709598 | 5 | 0 | 5 |
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