FGFR4

 

Full name: fibroblast growth factor receptor 4 Alias Symbol: JTK2|CD334
Type: protein-coding gene Cytoband: 5q35.2
Entrez ID: 2264 HGNC ID: HGNC:3691 Ensembl Gene: ENSG00000160867 OMIM ID: 134935
Drug and gene relationship at DGIdb

 

FGFR4 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04810Regulation of actin cytoskeleton

 

Expression of FGFR4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FGFR4 2264 1554962_a_at 0.0606 0.8251
GSE20347 FGFR4 2264 211237_s_at -0.0040 0.9679
GSE23400 FGFR4 2264 211237_s_at -0.0509 0.2080
GSE26886 FGFR4 2264 1554962_a_at 0.1444 0.2366
GSE29001 FGFR4 2264 211237_s_at -0.1627 0.2449
GSE38129 FGFR4 2264 204579_at 0.2493 0.0182
GSE45670 FGFR4 2264 1554962_a_at 0.0557 0.4088
GSE53622 FGFR4 2264 12071 -0.1490 0.0540
GSE53624 FGFR4 2264 12071 -0.0893 0.3507
GSE63941 FGFR4 2264 1554962_a_at 0.3648 0.0027
GSE77861 FGFR4 2264 1554961_at -0.0488 0.6536
GSE97050 FGFR4 2264 A_23_P92754 -0.2108 0.3225
SRP007169 FGFR4 2264 RNAseq 1.9525 0.0048
SRP133303 FGFR4 2264 RNAseq 0.4133 0.4504
SRP159526 FGFR4 2264 RNAseq 1.6372 0.0000
SRP193095 FGFR4 2264 RNAseq 0.9079 0.0656
SRP219564 FGFR4 2264 RNAseq 2.5492 0.0004
TCGA FGFR4 2264 RNAseq -0.1379 0.4259

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by FGFR4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FGFR4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FGFR4 2264 2 13 15
GSE20123 FGFR4 2264 2 13 15
GSE43470 FGFR4 2264 1 11 31
GSE46452 FGFR4 2264 0 27 32
GSE47630 FGFR4 2264 0 20 20
GSE54993 FGFR4 2264 10 2 58
GSE54994 FGFR4 2264 2 17 34
GSE60625 FGFR4 2264 1 0 10
GSE74703 FGFR4 2264 1 7 28
GSE74704 FGFR4 2264 1 6 13
TCGA FGFR4 2264 7 35 54

Total number of gains: 27; Total number of losses: 151; Total Number of normals: 310.  

 

Somatic mutations of FGFR4:

 

Generating mutation plots.

 

Highly correlated genes for FGFR4:

 

Showing top 20/533 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FGFR4DOK70.816271303
FGFR4SOHLH10.776944303
FGFR4TTC340.737679303
FGFR4TUSC10.735297303
FGFR4LRRC720.72696404
FGFR4HAUS50.714307303
FGFR4GDF70.712419303
FGFR4CCNJL0.709413303
FGFR4BCL2L120.707211303
FGFR4KCNT10.703329303
FGFR4TNFRSF250.70263303
FGFR4MAFA0.698605303
FGFR4ESPNL0.69505303
FGFR4PRR70.692115303
FGFR4CAPN130.687705303
FGFR4RNF1800.687197403
FGFR4MIXL10.686203303
FGFR4TNNI20.684297505
FGFR4MAMSTR0.683131404
FGFR4BPIFB40.682767303

For details and further investigation, click here